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Pyrrolopyridine

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Identification
Molecular formula
C8H7N
CAS number
1193-21-1
IUPAC name
1H-pyrrolo[3,2-c]pyridine
State
State

At room temperature, pyrrolopyridine is typically found as a liquid. It has a low melting point, which prevents it from solidifying under standard conditions.

Melting point (Celsius)
4.00
Melting point (Kelvin)
277.15
Boiling point (Celsius)
253.00
Boiling point (Kelvin)
526.15
General information
Molecular weight
118.15g/mol
Molar mass
118.1450g/mol
Density
1.1735g/cm3
Appearence

Pyrrolopyridine appears as a colorless to light yellow liquid. It is not commonly found in a pure solid form at room temperature due to its low melting point.

Comment on solubility

Solubility of 1H-pyrrolo[3,2-c]pyridine

1H-pyrrolo[3,2-c]pyridine, a bicyclic organic compound, exhibits specific solubility characteristics that are influenced by its structure. Understanding these solubility traits is crucial for its applications in various chemical processes.

Key Points on Solubility

  • Polarity: The compound has a moderate polarity due to the presence of nitrogen atoms in its structure, which significantly affects its solubility in different solvents.
  • Solvent Compatibility: 1H-pyrrolo[3,2-c]pyridine is generally soluble in polar organic solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Acetonitrile
    • Trifluoroacetic acid
  • Water Solubility: It shows low solubility in water, making it less favorable for aqueous applications. This is often due to its hydrophobic characteristics.

In summary, the solubility of 1H-pyrrolo[3,2-c]pyridine can be summarized as follows:

  1. Soluble in polar solvents.
  2. Poorly soluble in water.
  3. Moderate dissolution influenced by hydrogen bonding capabilities.

Understanding these solubility aspects is vital for chemists who work with this compound in synthesizing reactions and applications.

Interesting facts

Interesting Facts about 1H-pyrrolo[3,2-c]pyridine

1H-pyrrolo[3,2-c]pyridine is a fascinating compound that belongs to a family of nitrogen-containing heterocycles. This unique class of compounds finds significant applications in various fields, especially in medicinal chemistry. Here are some intriguing aspects of 1H-pyrrolo[3,2-c]pyridine:

  • Structural Versatility: The molecular structure of this compound features a bicyclic arrangement that is not only unique but also versatile, allowing for numerous synthetic modifications.
  • Pharmacological Relevance: 1H-pyrrolo[3,2-c]pyridine is known for its bioactive properties. It has been studied for its potential uses in developing novel therapeutic agents, particularly in treatments related to cancer.
  • Role in Drug Development: This compound serves as a critical scaffold in drug discovery, especially in designing kinase inhibitors which are essential for targeting various diseases.
  • Research Surface: Its inclusion in the study of receptor systems has opened new avenues for research in neuroscience and pharmacology, highlighting its importance in exploring brain function and disorders.
  • Comparison with Related Compounds: When compared to other nitrogen heterocycles, 1H-pyrrolo[3,2-c]pyridine stands out for its ability to interact with biological molecules due to its unique electronic properties.

In summary, 1H-pyrrolo[3,2-c]pyridine exhibits a combination of structural complexity and functional versatility that continues to intrigue scientists. As research advances, the potential applications of this compound are likely to expand, ushering in new innovations in pharmacology and related fields.

Synonyms
5-AZAINDOLE
271-34-1
1H-pyrrolo[3,2-c]pyridine
1,5-Diazaindene
1H-Pyrrolo(3,2-c)pyridine
3,7-Dideazapurine
MFCD00955936
BRN 0109684
271-32-9
DTXSID80181563
5-23-06-00304 (Beilstein Handbook Reference)
pyrrolo[3,2-c]pyridine
5-aza-indole
SCHEMBL67000
1H-Pyrrolo [3,2-c]pyridine
CHEMBL5192772
SCHEMBL15518410
DTXCID20104054
SRSKXJVMVSSSHB-UHFFFAOYSA-N
ALBB-037865
BCP27104
AC-860
BBL100076
STL220653
AKOS005254365
AKOS006375099
CS-W002711
FA16129
HY-W002711
PB12213
PS-5437
SY009136
1H-Pyrrolo[3,2-c]pyridine (5-Azaindole)
DB-006957
P1896
1,5-Diazaindene;1H-Pyrrolo[3,2-c]pyridine
EN300-67413
A818926
A818927
Z1079456082
InChI=1/C7H6N2/c1-4-9-7-2-3-8-5-6(1)7/h1-5,9
676-348-8