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5-Hydroxyquinoline

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Identification
Molecular formula
C9H7NO
CAS number
578-67-6
IUPAC name
1H-quinolin-5-one
State
State

At room temperature, 5-Hydroxyquinoline is typically found in a solid state as a crystalline powder.

Melting point (Celsius)
221.00
Melting point (Kelvin)
494.15
Boiling point (Celsius)
355.00
Boiling point (Kelvin)
628.15
General information
Molecular weight
159.16g/mol
Molar mass
159.1650g/mol
Density
1.3600g/cm3
Appearence

5-Hydroxyquinoline appears as an off-white to light yellow crystalline powder. It is usually softly luminescent under ultraviolet light.

Comment on solubility

Solubility of 1H-quinolin-5-one

1H-quinolin-5-one, also known by its systematic name, demonstrates an interesting profile when it comes to solubility in various solvents. Generally, this compound is found to be:

  • Slightly soluble in water
  • S soluble in organic solvents such as ethanol and methanol
  • Readily soluble in chloroform and dichloromethane

The solubility characteristics can be attributed to the compound's aromatic structure and the presence of functional groups that engage in hydrogen bonding and dipole interactions. It is vital to note that:

  1. The polar nature of the quinoline ring influences interactions with solvents.
  2. Temperature can significantly affect solubility; generally, an increase in temperature leads to enhanced solubility in organic solvents.

As a result, when working with 1H-quinolin-5-one, it’s essential to choose the appropriate solvent for dissolving and conducting reactions. This property plays a crucial role in its application in various chemical processes and research, where solubility impacts reactivity and bioavailability.

Interesting facts

Interesting Facts about 1H-quinolin-5-one

1H-quinolin-5-one is a fascinating compound with a variety of applications and properties that have captivated chemists and researchers alike. Here are some intriguing aspects of this compound:

  • Unique Structure: 1H-quinolin-5-one features a quinoline core, a bicyclic structure that consists of a benzene ring fused to a pyridine. This configuration is notable because it enables various chemical reactions and interactions.
  • Biological Activity: The compound has drawn attention for its potential biological activities. Several studies suggest that derivatives of quinolines, including 1H-quinolin-5-one, exhibit antimicrobial, antimalarial, and anticancer properties, making it a subject of interest in medicinal chemistry.
  • Synthetic Pathways: 1H-quinolin-5-one can be synthesized through various chemical reactions, including the oxidation of specific β-enamino ketones. Understanding these synthetic pathways is crucial for developing related compounds with enhanced properties.
  • Fluorescent Properties: This compound can exhibit interesting fluorescence characteristics, which are explored for applications in biological imaging and sensor technology. Scientists are continuously examining these properties for innovative uses.

Furthermore, researchers are actively exploring the role of 1H-quinolin-5-one in therapeutics, particularly in designing new drugs that target specific diseases. As we continue to uncover the versatility of this compound, its importance in various fields, from pharmacology to materials science, becomes increasingly evident.

In conclusion, 1H-quinolin-5-one is not just an intriguing molecule; it represents a gateway to numerous scientific inquiries and potential advancements across several disciplines.