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Quinoxalin-2(1H)-one

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Identification
Molecular formula
C8H6N2O
CAS number
59-31-4
IUPAC name
1H-quinoxalin-2-one
State
State

The compound is typically solid at room temperature. It is in the form of a powder which makes it easy to handle and weigh for experimental purposes. Care should be taken to keep it in a light-protected container to preserve its stability.

Melting point (Celsius)
207.00
Melting point (Kelvin)
480.15
Boiling point (Celsius)
501.70
Boiling point (Kelvin)
774.85
General information
Molecular weight
146.14g/mol
Molar mass
146.1440g/mol
Density
1.3250g/cm3
Appearence

Quinoxalin-2(1H)-one appears as a white to light yellow crystalline powder. It is known for its characteristic crystalline structure which is stable under standard conditions. The compound is light-sensitive and can degrade upon prolonged exposure to light.

Comment on solubility

Solubility of 1H-Quinoxalin-2-one

1H-quinoxalin-2-one, with the chemical formula C8H6N2O, exhibits notable solubility characteristics in various solvents, making it an interesting compound for further study. Here are some key points regarding its solubility:

  • Solvent Dependence: This compound is known to be soluble in organic solvents such as dimethyl sulfoxide (DMSO), ethanol, and methanol. The polar nature of these solvents facilitates the dissolution of 1H-quinoxalin-2-one.
  • Water Solubility: 1H-quinoxalin-2-one shows limited solubility in water, which can be attributed to its relatively non-polar aromatic structure.
  • Temperature Influence: In general, increasing the temperature can enhance the solubility of many organic compounds, including 1H-quinoxalin-2-one, in organic solvents.

Overall, when exploring the solubility of 1H-quinoxalin-2-one, it is critical to consider the solvent’s properties, as they play a significant role in determining the compound's behavior in solution. As noted, this compound exhibits solubility trends that are primarily influenced by solvent polarity and temperature conditions.

Interesting facts

Interesting Facts about 1H-quinoxalin-2-one

1H-quinoxalin-2-one is a fascinating heterocyclic compound that plays a significant role in various scientific fields. Here are some intriguing aspects of this compound:

  • Structure and Function: This compound features a fused bicyclic structure that incorporates a quinoxaline moiety, which is known for its versatile chemical properties. The presence of the nitrogen atoms contributes to its rich reactivity.

  • Pharmaceutical Applications: 1H-quinoxalin-2-one has been the subject of numerous studies due to its potential pharmacological activities. It is known to exhibit antibacterial, antifungal, and antiviral properties, making it a candidate for drug development.

  • Antioxidant Activity: Research indicates that this compound may possess antioxidant properties, which can help in combating oxidative stress in biological systems. This is particularly important in the development of therapies for diseases related to oxidative damage.

  • Bioactivity: Compounds featuring the quinoxalin-2-one scaffold have displayed a range of bioactivity, including neuroprotective effects. This opens up possibilities for its use in neurodegenerative disease treatments.

  • Research Significance: Ongoing research continues to explore synthetic modifications of 1H-quinoxalin-2-one to enhance its efficacy in various applications. Scientists are keen to discover derivatives that may improve its therapeutic utility.

In summary, 1H-quinoxalin-2-one is more than just a simple compound; it is a pivotal entity in medicinal chemistry, offering a gateway to innovative drug discovery and development. As researchers unveil its full potential, we can anticipate exciting advancements in the fields of pharmaceuticals and biotechnology.

Synonyms
2-Hydroxyquinoxaline
1196-57-2
2-QUINOXALINOL
2(1H)-Quinoxalinone
Quinoxalin-2(1H)-one
3-Quinoxalinone
2-Quinoxalone
EINECS 214-815-6
NSC 13154
AI3-22771
DTXSID6061604
DTXCID8033512
214-815-6
quinoxalin-2-ol
2-Quinoxalinone
Quinoxalin-2-one
144499-26-3
1H-quinoxalin-2-one
1,2-Dihydroquinoxalin-2-one
Quinoxaline-2-one
quinoxalinone
2-Quinoxalinol(9CI)
Quinalphos free hydroxy
MFCD00006722
2-quinoxinol
quinoxaline-2-ol
2-hydroxy-benzopyrazine
quinoxaline, 2-hydroxy-
SCHEMBL37862
2-keto-1,2-dihydroquinoxaline
WLN: T66 BN ENJ CQ
CHEBI:38890
2-Quinoxalinol, 99% (HPLC)
HMS1623H17
ALBB-024162
BCP30468
NSC13154
NSC-13154
STL139322
AKOS000120904
AKOS003236140
CCG-321752
CS-W018235
HY-W017519
AC-23582
SY013680
TS-01898
DB-041490
DB-063542
H0591
NS00023871
EN300-16930
F16123
P50007
10.14272/FFRYUAVNPBUEIC-UHFFFAOYSA-N.1
10.14272/FFRYUAVNPBUEIC-UHFFFAOYSA-N.2
10.14272/FFRYUAVNPBUEIC-UHFFFAOYSA-N.3
AB-323/25048501
doi:10.14272/FFRYUAVNPBUEIC-UHFFFAOYSA-N.1
doi:10.14272/FFRYUAVNPBUEIC-UHFFFAOYSA-N.2
doi:10.14272/FFRYUAVNPBUEIC-UHFFFAOYSA-N.3
doi:10.14272/FFRYUAVNPBUEIC-UHFFFAOYSA-N.4
Q27118020
Z56824051
F1775-0040
InChI=1/C8H6N2O/c11-8-5-9-6-3-1-2-4-7(6)10-8/h1-5H,(H,10,11
2-Hydroxyquinoxaline pound>>Quinoxalin-2-ol pound>>Quinoxalin-2(1H)-one pound>>1,2-Dihydroquinoxalin-2-one