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Gallopamil hydrochloride

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Identification
Molecular formula
C27H38Cl2N2O4
CAS number
16662-47-8
IUPAC name
(1R)-1-[[(3R)-3-ethyl-9,10-dimethoxy-1,2,3,4,5,6,7,11b-octahydrobenzo[a]quinolizin-5-ium-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-6-ol;dichloride
State
State

At room temperature, gallopamil hydrochloride is generally in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
133.00
Melting point (Kelvin)
406.15
Boiling point (Celsius)
259.00
Boiling point (Kelvin)
532.15
General information
Molecular weight
512.50g/mol
Molar mass
512.4950g/mol
Density
1.2071g/cm3
Appearence

Gallopamil hydrochloride typically appears as a white or off-white crystalline powder.

Comment on solubility

Solubility of (1R)-1-[[[3R]-3-ethyl-9,10-dimethoxy-1,2,3,4,5,6,7,11b-octahydrobenzo[a]quinolizin-5-ium-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-6-ol;dichloride

The solubility of the compound (1R)-1-[[[3R]-3-ethyl-9,10-dimethoxy-1,2,3,4,5,6,7,11b-octahydrobenzo[a]quinolizin-5-ium-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-6-ol;dichloride can be considered complex due to its intricate structure. Several factors influence its solubility characteristics:

  • Polarity: The presence of multiple methoxy (-OCH3) and quaternary ammonium groups can enhance polar interactions with solvents, potentially increasing solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds, especially with water molecules, may significantly influence its aqueous solubility.
  • Salt Formation: Since this compound is a dichloride salt, it is often more soluble in polar solvents compared to its free base form.
  • Temperature Dependence: Solubility may also vary significantly with temperature; typically, higher temperatures can lead to greater solubility.

In summary, while the solubility characteristics of this compound are complicated, it is likely to exhibit a notable degree of solubility in polar environments due to its structure. Further empirical studies would be essential to quantify its solubility in various solvents.

Interesting facts

Exploring an Intriguing Compound

The compound (1R)-1-[[(3R)-3-ethyl-9,10-dimethoxy-1,2,3,4,5,6,7,11b-octahydrobenzosup>bquinolizin-5-ium-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-6-ol;dichloride is a fascinating example of modern synthetic chemistry, showcasing both structural complexity and potential biological activity.

Key Aspects of the Compound

  • Synthetic Versatility: This compound illustrates the art of organic synthesis, where multiple functional groups are carefully combined to achieve a desired biological profile.
  • Functional Diversity: The presence of methoxy groups and a multi-ring structure suggest potential interactions with various biological targets, making it a candidate for pharmacological exploration.
  • Stereochemistry: The specific stereoisomers, particularly at the 1R and 3R positions, can greatly influence the compound's reactivity and interaction with biological systems.

Scientists often highlight the importance of such compounds in drug discovery. As emphasized by researchers, “Compounds with complex structures often exhibit unique mechanisms of action, which can lead to breakthrough therapies.” This compound's structural configuration potentially allows it to offer unique advantages in medicinal chemistry.

Moreover, the dichloride salt form may improve solubility and stability, which are critical factors in the development of pharmaceuticals.

Potential Applications

  • Medicinal Chemistry: With its intricate architecture, this compound may serve as a lead compound for developing new therapeutics.
  • Drug Delivery: The tetrahydroisoquinoline moiety can help facilitate delivery across biological membranes.
  • Research Tool: It could act as a chemical probe in studies aimed at understanding receptor interactions and signaling pathways.

The journey of uncovering the properties and applications of compounds like this one is an exhilarating aspect of the chemistry landscape, where each new discovery can potentially lead to improved health outcomes and deeper scientific insight.