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Galanthamine

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Identification
Molecular formula
C17H21NO3
CAS number
357-70-0
IUPAC name
(1R)-1-[[(3R)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol
State
State
Galanthamine is typically found in a solid state at room temperature, appearing as a crystalline powder in its pure form.
Melting point (Celsius)
127.00
Melting point (Kelvin)
400.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
287.35g/mol
Molar mass
287.3550g/mol
Density
1.3300g/cm3
Appearence
Galanthamine is a white to off-white crystalline powder. It is not hygroscopic and is relatively stable under normal conditions of storage and use.
Comment on solubility

Solubility of (1R)-1-[[[3R]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol

The solubility of complex organic compounds such as (1R)-1-[[[3R]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol can vary significantly based on several key factors. Here are some insightful points regarding its solubility:

  • Polarity: The solubility of this compound may largely depend on the distribution of polar and non-polar functional groups within its structure. The presence of methoxy groups can enhance solubility in polar solvents.
  • Hydrogen Bonding: Functional groups capable of hydrogen bonding may improve solubility in protic solvents. With the hydroxyl group featured in the structure, solubility in alcohols could be significant.
  • Temperature: Like many organic compounds, the solubility may increase with temperature. Solutions might become saturated at higher temperatures, allowing for greater dissolution of the compound.
  • Solvent Type: The choice of solvent is critical. This compound might be more soluble in organic solvents like ethanol or methanol compared to water.
  • Crystallinity: The physical form of the compound, such as whether it is crystalline or amorphous, can also influence its solubility.

Understanding the solubility of such complex compounds is crucial. As it is often stated, “Like dissolves like,” indicating that compounds with similar polarcharacteristics will tend to dissolve in one another. Thus, examining the molecular structure and the nature of interactions in solution is essential for predicting its solubility profile.

Interesting facts

Interesting Facts about (1R)-1-[[(3R)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzosup[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol

This compound is a fascinating example of a complex organic molecule, exhibiting intriguing chemical structure and potential biological activity. Here are some remarkable aspects:

  • Structural Complexity: The compound features multiple rings, including a benzoquinolizine and a tetrahydroisoquinoline framework, which contributes to its rich chemical properties.
  • Potential Biological Activity: Compounds related to this structure are often studied for their potential pharmacological effects, including interactions with neurotransmitter systems, which may lead to therapeutic applications.
  • Chirality: The designation of (1R) and (3R) specifies chiral centers in the molecule, indicating that this compound may exhibit different biological activities depending on its stereochemistry.
  • Natural Inspiration: Many complex organic compounds such as this one are inspired by natural products. The biological pathways of certain plants lead to the synthesis of structurally similar compounds, which have beneficial properties.
  • Research Relevance: The unique structure allows for diverse synthetic pathways, making it an appealing target for chemists looking to develop novel drugs or study their mechanisms of action.

"The beauty of organic chemistry lies in the complexity and diversity of molecular structures we can create and study."

This compound exemplifies the thrilling intersection of synthetic chemistry and medicinal applications, emphasizing how intricate structures can lead to significant advances in science. The ongoing research into such compounds could potentially unveil new treatments or therapies that enhance our understanding of human health.