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Galanthamine

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Identification
Molecular formula
C17H21NO3
CAS number
357-70-0
IUPAC name
(1R)-1-[[(3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol
State
State

At room temperature, galanthamine is in a solid state, typically found as a crystalline powder suitable for use in pharmaceuticals.

Melting point (Celsius)
123.15
Melting point (Kelvin)
396.30
Boiling point (Celsius)
358.15
Boiling point (Kelvin)
631.30
General information
Molecular weight
287.35g/mol
Molar mass
287.3530g/mol
Density
1.2280g/cm3
Appearence

Galanthamine is typically a white to off-white crystalline powder. It is often processed into tablets or solutions for its application in medicine.

Comment on solubility

Solubility of (1R)-1-[[(3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[[/a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol

The solubility of complex organic compounds, such as (1R)-1-[[[3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[[/a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol, can greatly vary depending on several factors. In general, solubility is influenced by:

  • Polarity of the Molecule: Water-soluble compounds are typically polar, while non-polar compounds are better dissolved in organic solvents.
  • Hydrogen Bonding: The ability of a molecule to form hydrogen bonds with water can greatly increase its solubility.
  • Molecular Size: Larger molecules may experience steric hindrance that affects their solubility in different solvents.
  • Temperature: Generally, solubility increases with an increase in temperature, though exceptions exist.

For this specific compound, it is hypothesized that its solubility may be limited due to:

  • Multiple methoxy groups that may create steric hindrance.
  • Its relatively large and complex structure, which could impede interactions with polar solvents.

In conclusion, knowing the nature of the solvent and the environmental conditions is essential when considering the solubility of such intricate compounds. Understanding these characteristics can prove invaluable for applications in fields such as pharmaceuticals and materials science.

Interesting facts

Interesting Facts about (1R)-1-[[3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol

This compound is a fascinating example of complex organic chemistry, showcasing the rich diversity of alkaloids. Here are some interesting aspects to consider:

  • Complex Structure: The compound features multiple chiral centers, which suggests it is likely to have unique stereochemistry. This complexity can influence its pharmacological behavior and interactions with biological systems.
  • Alkaloid Nature: It belongs to a class of compounds known as alkaloids, which are often derived from plant sources. Alkaloids are renowned for their diverse biological activities, making them of great interest in medicinal chemistry.
  • Potential Therapeutic Applications: Due to its intricate structure, compounds like this one may possess potential for drug development. Researchers often explore such molecules for their effects on the central nervous system, including analgesic or psychoactive properties.
  • Natural Origins: Many alkaloids are isolated from plants and have historically been used in traditional medicine. Understanding the biosynthetic pathways of such compounds can lead to sustainable production methods.
  • Research Significance: The study of such intricate compounds can provide insights into reaction mechanisms and the design of new synthetic routes, which is crucial for advancing the field of organic chemistry.

In the words of renowned chemist Linus Pauling, "The science of chemistry is not an isolated activity; it is a key to [understanding] the world." This compound exemplifies that philosophy, highlighting the interconnectedness of chemistry with the natural world and medicine.

Overall, (1R)-1-[[3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol represents the intricate art of organic chemistry and offers potential pathways for future pharmaceutical innovations.

Synonyms
CHEMBL5411599