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Chlorambucil

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Identification
Molecular formula
C14H19Cl2NO2
CAS number
305-03-3
IUPAC name
[(1R)-2-[4-[bis(2-chloroethyl)amino]phenyl]-1-carboxy-ethyl]ammonium;chloride
State
State

At room temperature, Chlorambucil is typically a solid.

Melting point (Celsius)
61.00
Melting point (Kelvin)
334.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
305.68g/mol
Molar mass
304.6790g/mol
Density
1.3640g/cm3
Appearence

Chlorambucil appears as a white to pale yellow crystalline powder.

Comment on solubility

Solubility of [(1R)-2-[4-[bis(2-chloroethyl)amino]phenyl]-1-carboxy-ethyl]ammonium;chloride

The solubility of the compound [(1R)-2-[4-[bis(2-chloroethyl)amino]phenyl]-1-carboxy-ethyl]ammonium;chloride can be considered through various aspects:

  • Polar Nature: Due to the presence of multiple chlorine atoms and a quaternary ammonium group, the compound is likely to exhibit polar characteristics, which can enhance its solubility in polar solvents such as water.
  • Hydrochloride Salt: As a hydrochloride salt, it tends to be more soluble in aqueous solutions compared to its freebase form, making it accessible for various chemical reactions and biological applications.
  • Miscibility: The solubility may vary significantly with changes in temperature and the presence of other solutes, which can affect its behavior in solution.
  • Practical Applications: Due to its solubility profile, this compound can be utilized effectively in medicinal chemistry, particularly in formulations for therapeutic use.

Overall, while the exact solubility can be influenced by several environmental and chemical factors, the presence of polar functional groups generally suggests that the compound may have good solubility in appropriate solvents.

Interesting facts

Interesting Facts about [(1R)-2-[4-[bis(2-chloroethyl)amino]phenyl]-1-carboxy-ethyl]ammonium;chloride

This compound, often recognized for its potential in the field of medicinal chemistry, belongs to a class of compounds that are primarily utilized as therapeutic agents. The presence of the bis(2-chloroethyl)amino group is particularly noteworthy as it is commonly associated with the mechanism of action of certain chemotherapy drugs. Here are some intriguing aspects of this compound:

  • Antineoplastic Properties: The structure is reminiscent of nitrogen mustards, which are recognized for their effectiveness in cancer treatment. They work by alkylating DNA, thus interfering with cell division.
  • Target Specificity: Compounds like this one can be designed to target specific tumor types, which enhances the precision of treatment while potentially minimizing side effects.
  • Research Significance: Scientists frequently study this compound to understand its interaction with biological systems—helping to pave the way for novel therapies.
  • Structure-Activity Relationship (SAR): The intricate molecular structure provides a rich platform for examining how various substituents can affect biological activity and pharmacokinetics.

Furthermore, the incorporation of the ammonium moiety in the structure adds an interesting layer of pharmacological activity.
The ionization of the amine function can influence solubility and bioavailability, which are critical parameters in drug formulation.

In conclusion, the exploration of [(1R)-2-[4-[bis(2-chloroethyl)amino]phenyl]-1-carboxy-ethyl]ammonium;chloride is a testament to the synergy between organic chemistry and medicine, showcasing how understanding chemical structures can lead to innovative solutions in disease treatment.