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Codeine

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Identification
Molecular formula
C18H21NO3
CAS number
76-57-3
IUPAC name
(1R)-7-methoxy-11a-methyl-3,3a,3b,4,5,9b,10,11-octahydro-1H-naphtho[2,1-e]isobenzofuran-1-ol
State
State

At room temperature, codeine is typically in a solid state as a crystalline substance.

Melting point (Celsius)
154.00
Melting point (Kelvin)
427.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
299.36g/mol
Molar mass
299.3640g/mol
Density
1.3448g/cm3
Appearence

Codeine is a crystalline solid that is white to off-white in appearance. It usually occurs in the form of small crystals or crystalline powder and may have a slightly bitter taste.

Comment on solubility

Solubility of (1R)-7-methoxy-11a-methyl-3,3a,3b,4,5,9b,10,11-octahydro-1H-naphtho[2,1-e]isobenzofuran-1-ol

The solubility of (1R)-7-methoxy-11a-methyl-3,3a,3b,4,5,9b,10,11-octahydro-1H-naphtho[2,1-e]isobenzofuran-1-ol can be characterized by several key factors:

  • Polarity: The presence of the methoxy group and hydroxyl group in the structure increases the polarity of the compound, suggesting it may have moderate solubility in polar solvents like water.
  • Hydrophobic Character: The bulky naphthofuran structure indicates significant hydrophobic characteristics, which might limit solubility in highly polar solvents but enhance solubility in non-polar solvents like organic solvents.
  • Temperature Dependence: As with many organic compounds, solubility often increases with temperature, meaning that solubility tests should be conducted at varying temperatures for an accurate assessment.
  • Effect of pH: The solubility of this compound may also be affected by the pH of the solution, especially due to the hydroxyl group, which could either protonate or deprotonate in response to extreme pH conditions.

Overall, the solubility profile of this compound is likely to be influenced by a delicate balance between its polar and non-polar attributes. As such, understanding its solubility requires careful consideration of its structural components and the environmental conditions of the solvent used.

Interesting facts

Interesting Facts about (1R)-7-methoxy-11a-methyl-3,3a,3b,4,5,9b,10,11-octahydro-1H-naphtho[2,1-e]isobenzofuran-1-ol

(1R)-7-methoxy-11a-methyl-3,3a,3b,4,5,9b,10,11-octahydro-1H-naphtho[2,1-e]isobenzofuran-1-ol is a fascinating compound due to its unique structural features and potential applications.

  • Cyclic Structure: This compound possesses a complex cyclic structure, highlighting the diverse possibilities within organic chemistry for constructing multi-ring systems.
  • Biological Activity: Compounds with similar structures often exhibit various pharmacological activities, making them interesting candidates for medicinal chemistry. The specific stereochemistry in this compound can play a critical role in its biological interactions.
  • Natural Analogues: It is worth noting that many compounds resembling this one can be found in nature, often derived from plant sources. Studying such compounds can provide insights into their medicinal properties and ecological roles.
  • Research Potential: The intricate nature of this compound encourages explorations in synthetic organic chemistry. Scientists may aspire to develop new synthetic pathways for efficient production, enhancing its availability for research.
  • Chirality: Being chiral, this compound can exist in multiple stereoisomeric forms. Understanding the impact of chirality on biological activity is a significant focus in drug development.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This compound undoubtedly presents a multitude of avenues for exploration in both academic and applied science contexts. Its unique chemical framework not only showcases the beauty of organic chemistry but also invites researchers to delve deeper into its functional properties.