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Harmine

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Identification
Molecular formula
C13H12N2O
CAS number
442-51-3
IUPAC name
(1R,13R,15S,17S,18R)-17-ethyl-7-methoxy-3-azapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4(9),5,7-tetraene
State
State

Harmine is typically observed as a solid at room temperature. It is crystalline in nature, adding to its stable form under these conditions.

Melting point (Celsius)
256.00
Melting point (Kelvin)
529.15
Boiling point (Celsius)
383.00
Boiling point (Kelvin)
656.15
General information
Molecular weight
212.25g/mol
Molar mass
212.2460g/mol
Density
1.2500g/cm3
Appearence

Harmine typically appears as a yellow crystalline solid. It can also exist as off-white to pale yellow crystals when purified, which is the form encountered in scientific research and laboratory settings. This compound is known to fluoresce under UV light, which is characteristic of some alkaloids.

Comment on solubility

Solubility Overview

The solubility of (1R,13R,15S,17S,18R)-17-ethyl-7-methoxy-3-azapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4(9),5,7-tetraene is a critical aspect to understanding its chemical behavior and potential applications. Given its complex structure, several factors influence its solubility:

  • Polarity: Its intricate arrangement of functional groups, including the ethyl and methoxy groups, can affect the overall polarity. Generally, more polar compounds dissolve well in polar solvents.
  • Hydrogen Bonding: The presence of methoxy groups may facilitate *hydrogen bonding* with solvents, potentially increasing solubility in polar environments.
  • Solvent Compatibility: Solubility can be significantly influenced by the choice of solvent. For instance, it is expected to have better solubility in organic solvents like ethanol or methanol than in water due to its relative hydrophobicity.
  • Molecular Weight: With its substantial molecular weight stemming from a complex structure, this can lead to lower solubility compared to simpler, smaller compounds.

To summarize, the solubility characteristics of this compound hinge on its molecular structure and the solvent's nature. As a result, it may exhibit variable solubility, being better suited for use in organic synthesis rather than aqueous environments. Understanding these solubility properties is essential for effective handling and application in laboratory and industrial settings.

Interesting facts

Interesting Facts About (1R,13R,15S,17S,18R)-17-ethyl-7-methoxy-3-azapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4(9),5,7-tetraene

This intriguing compound showcases the complex world of organic chemistry with its unique structure and potential applications. Here are some fascinating aspects to consider:

  • Structural Complexity: The name itself indicates a highly intricate scaffold composed of multiple fused rings. This pentacyclic structure allows for unique chemical properties and reactivity, making it a topic of great interest in synthetic chemistry.
  • Chirality and Isomerism: With multiple stereocenters, this compound possesses a high degree of chirality, which can result in different biological activities for its various stereoisomers. Understanding these differences is crucial for applications in pharmacology.
  • Natural Product Inspirations: Compounds with similar frameworks are often found in nature, particularly in alkaloids and other bioactive molecules. Studying this compound could provide insights into its natural analogs and their effects.
  • Potential Applications: The structural characteristics of this compound position it well for exploration in medicinal chemistry. It may exhibit interesting biological activities and could serve as a lead compound in drug discovery.
  • Research Opportunities: Chemists are continually looking for new ways to synthesize complex molecules. This compound's intricate design invites students and researchers alike to explore innovative synthetic pathways and methodologies.

In the words of one excited scientist, "Every new compound is a new story waiting to be told." The exploration of (1R,13R,15S,17S,18R)-17-ethyl-7-methoxy-3-azapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4(9),5,7-tetraene is just the beginning of uncovering the keys it may hold for future scientific advancements.