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Methamphetamine sulfate

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Identification
Molecular formula
C10H15NO2 · 0.5 H2SO4
CAS number
78-44-4
IUPAC name
(1R,2S)-2-(methylamino)-1-phenyl-propan-1-ol;(1R,2R)-2-(methylamino)-1-phenyl-propan-1-ol;sulfuric acid
State
State

At room temperature, sulfuric acid is a dense, oily liquid. It is typically encountered in a laboratory or industrial setting as a liquid with high viscosity.

Melting point (Celsius)
10.31
Melting point (Kelvin)
283.46
Boiling point (Celsius)
337.00
Boiling point (Kelvin)
610.15
General information
Molecular weight
337.48g/mol
Molar mass
337.4820g/mol
Density
1.2840g/cm3
Appearence

Sulfuric acid is a colorless to slightly yellow viscous liquid that is very corrosive. When pure, it is usually colorless, but impurities can cause it to appear yellow. It is soluble in water, with the release of heat.

Comment on solubility

Solubility of (1R,2S)-2-(methylamino)-1-phenyl-propan-1-ol and (1R,2R)-2-(methylamino)-1-phenyl-propan-1-ol

The solubility of the compounds (1R,2S)-2-(methylamino)-1-phenyl-propan-1-ol and (1R,2R)-2-(methylamino)-1-phenyl-propan-1-ol is an intriguing subject, especially when considering their molecular structure. These chiral compounds exhibit unique solubility characteristics influenced by the presence of the methylamino group and the phenyl ring.

Key Features of Solubility:

  • Polarity: The presence of the methylamino group, which contains an -NH2 moiety, contributes significantly to the polarity of the molecules, enhancing their ability to dissolve in polar solvents like water.
  • Hydrogen Bonding: The amine group can form hydrogen bonds with water molecules, further aiding in solubility by creating interactions that stabilize the solute in a solvent medium.
  • Steric Effects: The configuration of these compounds as enantiomers might influence their solubility; (1R,2S) may exhibit different solubility characteristics compared to (1R,2R) due to steric hindrance.

Moreover, in the presence of sulfuric acid, the solubility can be significantly altered. Sulfuric acid, being a strong acid, can protonate the amine group, potentially enhancing solubility in polar solvents and changing the compound's overall behavior in solution.

In summary, the solubility of these compounds is characterized by:

  1. Increased solubility in polar solvents due to their functional groups.
  2. The potential for varied solubility behaviors based on chirality.
  3. Enhanced interactions when exposed to strong acids like sulfuric acid.

Understanding these solubility factors is essential for applications in pharmaceuticals and organic synthesis, where the ability to manipulate solubility can lead to improved outcomes in chemical processes.

Interesting facts

Interesting Facts about (1R,2S)-2-(methylamino)-1-phenyl-propan-1-ol and (1R,2R)-2-(methylamino)-1-phenyl-propan-1-ol

The compounds known as (1R,2S)-2-(methylamino)-1-phenyl-propan-1-ol and (1R,2R)-2-(methylamino)-1-phenyl-propan-1-ol are intriguing members of the family of drugs known as sympathomimetics. Below are some fascinating insights into these compounds:

  • Chirality: Both compounds exhibit chirality, meaning they exist as enantiomers. Chirality is a key feature in pharmaceuticals, as even minor variations in molecular orientation can result in vastly different biological activities.
  • Pharmacological Impact: These compounds have been studied for their potential effects on the central nervous system, which may include stimulating actions that can elevate mood or energy levels.
  • Applications in Medicine: Due to their structural similarity to natural neurotransmitters, they have garnered interest as potential treatments for conditions such as depression and attention deficit hyperactivity disorder (ADHD).
  • Synthesis Techniques: The synthesis of these compounds often involves intricate organic reactions and careful stereochemical control, illustrating the remarkable complexity of modern synthetic chemistry.

Role of Sulfuric Acid

Sulfuric acid plays a pivotal role in various chemical synthesis processes:

  • Dehydrating Agent: As a strong dehydrating agent, sulfuric acid is often employed in reactions where the removal of water facilitates the formation of desired products.
  • Catalyst Function: It acts as a catalyst, enhancing reaction rates and yielding greater efficiency in laboratory settings.
  • Acid-Base Reactions: In the presence of basic compounds, sulfuric acid can drive acid-base reactions producing salts and water, which are fundamental in creating various chemical intermediates.

In summary, (1R,2S)-2-(methylamino)-1-phenyl-propan-1-ol and (1R,2R)-2-(methylamino)-1-phenyl-propan-1-ol showcase the complexity and excitement of chemistry, highlighting just how critical structure is in determining function. Their interactions with sulfuric acid further underscore the intricate dance of chemical reactions that form the foundation of modern synthetic chemistry.