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Camptothecin

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Identification
Molecular formula
C20H16N2O4
CAS number
7689-03-4
IUPAC name
(1R,3R,5S,13R,14S)-1-hydroxy-14-(1-hydroxy-1-methyl-ethyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione
State
State

At room temperature, camptothecin is in a solid state. Due to its crystalline structure, it maintains a solid form under standard conditions, which includes room temperature and atmospheric pressure.

Melting point (Celsius)
264.00
Melting point (Kelvin)
537.00
Boiling point (Celsius)
485.00
Boiling point (Kelvin)
758.15
General information
Molecular weight
348.35g/mol
Molar mass
0.0000g/mol
Density
1.2200g/cm3
Appearence

Camptothecin appears as a pale yellow crystalline powder or solid. Its crystalline nature can be observed under a microscope, showcasing distinct structural formations. The compound is known for its solid state which is typical for many alkaloids derived from natural sources.

Comment on solubility

Solubility of (1R,3R,5S,13R,14S)-1-hydroxy-14-(1-hydroxy-1-methyl-ethyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione

The solubility of complex organic compounds like (1R,3R,5S,13R,14S)-1-hydroxy-14-(1-hydroxy-1-methyl-ethyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione can be influenced by several factors. Here are important aspects to consider:

  • Polarity: The presence of multiple hydroxyl groups suggests that this compound may exhibit hydrophilicity, potentially increasing solubility in polar solvents such as water.
  • Hydrophobic regions: The extensive multi-cyclic structure could imply hydrophobic properties, making the compound less soluble in non-polar solvents.
  • Temperature: Similar to many organic compounds, solubility may vary with temperature; generally, increased temperatures can lead to higher solubility.
  • pH Levels: Variation in acidity or alkalinity can influence the ionization of the hydroxyl groups, thereby affecting solubility.

In summary, while this compound may demonstrate some level of solubility in polar solvents due to its functional groups, the intricate structure also implies potential limitations in solubility in non-polar environments. As the old adage goes, "Like dissolves like," which holds true in evaluating the solubility of such complex chemical species. Understanding the specific conditions under which solubility is optimal is crucial for practical applications.

Interesting facts

Interesting Facts about (1R,3R,5S,13R,14S)-1-hydroxy-14-(1-hydroxy-1-methyl-ethyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione

This compound showcases the fascinating complexity of organic chemistry through its intricate structure and functional groups. Here are some captivating aspects of this compound:

  • Structural Complexity: With its unique pentacyclic framework, this compound is an excellent example of how molecular architecture can influence the properties and reactivity of a chemical.
  • Natural Occurrence: Compounds with similar structures may be found in nature, often playing critical roles in biological processes, such as signaling pathways or serving as secondary metabolites in plants.
  • Stereochemistry: The presence of multiple chiral centers (1R, 3R, 5S, 13R, 14S) demonstrates the importance of stereochemistry in determining the behavior and interactions of the molecule within biological systems.
  • Potential Applications: Due to its multi-functional characteristics, this compound could be explored for applications in pharmaceuticals or as potential agrochemicals, emphasizing the need for continued research.
  • Research Interest: The complexity of its structure may offer insights into synthetic chemistry challenges, leading to novel synthetic routes and methodologies.

In summary, the fascinating characteristics of (1R,3R,5S,13R,14S)-1-hydroxy-14-(1-hydroxy-1-methyl-ethyl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione illustrate the depth of study in organic compounds and their potential implications across various fields. As scientists continue to explore compounds like this, our understanding of their role in nature and utility in technology will only grow.