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Ipratropium bromide

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Identification
Molecular formula
C20H30BrNO3
CAS number
22254-24-6
IUPAC name
[(1R,5R)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-propylpentanoate
State
State

At room temperature, ipratropium bromide exists as a solid. It is typically found in powder form, which facilitates its use in inhalers and other delivery mechanisms for medicinal purposes.

Melting point (Celsius)
231.00
Melting point (Kelvin)
504.15
Boiling point (Celsius)
230.00
Boiling point (Kelvin)
503.15
General information
Molecular weight
430.38g/mol
Molar mass
430.3800g/mol
Density
1.1210g/cm3
Appearence

Ipratropium bromide appears as a white or off-white crystalline powder. It is known to be odorless and is typically used in its anhydrous form. The fine powdery texture is typical of many bromide salts.

Comment on solubility

Solubility of [(1R,5R)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-propylpentanoate

The solubility of **[(1R,5R)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-propylpentanoate** presents an intriguing study due to its unique structural features. Several factors affect the solubility of this compound, including:

  • Polarity: The presence of the azonium group contributes to the overall polarity, which may enhance solubility in polar solvents such as water.
  • Chain Length: The 2-propylpentanoate moiety introduces hydrophobic characteristics, potentially limiting solubility in polar environments.
  • Hydrogen Bonding: The structure may engage in hydrogen bonding, increasing interaction with water, depending on the solvent condition.

In general, the solubility behavior can be summarized as:

  1. **Highly soluble** in polar solvents due to azonium presence.
  2. **Moderately soluble** in nonpolar solvents due to hydrocarbon chain effects.
  3. **Limited solubility** at elevated temperatures might be observed, depending on the surrounding environmental conditions.

An understanding of solubility not only delves into theoretical aspects but also applies to practical scenarios, such as formulation in pharmaceuticals, wherein:

  • Solubility can dictate bioavailability
  • Improved solubility can enhance therapeutic efficacy
  • Incompatibilities may arise in multicomponent systems

Therefore, investigating the solubility of this compound is essential for maximizing its potential applications and understanding its behavior in various biological and industrial systems.

Interesting facts

Exploring the Unique Compound: [(1R,5R)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-propylpentanoate

This fascinating compound, known for its intricate structure, presents an intriguing branch of organic chemistry, specifically within the realm of bicyclic amines. Here are some interesting facts about this compound:

  • Structure and Stereochemistry: The designation "(1R,5R)" indicates specific stereochemistry, which is crucial for understanding the compound's interactions and behavior in biological systems. Stereochemistry plays a significant role in pharmacology and the design of drugs, where certain stereoisomers can have different biological activities.
  • Bicyclic Nature: The bicyclo[3.2.1]octane structure is an example of a bridged bicyclic system. This unique arrangement not only affects the compound’s reactivity but also its physical and chemical properties. Bicyclic structures can exhibit interesting tensions and strain, leading to unique reactivity patterns.
  • Quaternary Ammonium Character: The presence of a quaternary ammonium moiety (the azonium part) introduces a cationic center, making it a subject of interest in ionic liquids and surfactant research. Quaternary ammonium compounds often demonstrate antimicrobial properties, which can lead to potential applications in biochemistry and materials science.
  • Potential Applications: Due to its complex structure, this compound may find application in medicinal chemistry as a potential therapeutic agent. Compounds of this type are often explored for their effects on neurotransmitter receptors, which can result in valuable insights in drug development.
  • Natural Product Inspiration: Many bicyclic compounds are derived from natural products, suggesting that this molecule could lead to discoveries that mimic or enhance biological pathways found in nature.

In conclusion, the compound [(1R,5R)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-propylpentanoate is more than just a chemical entity; it is a gateway into the complex world of organic synthesis and molecular interaction. As we continue to unravel the mysteries of such compounds, the potential for discovering innovative applications becomes ever more exciting!