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Erythromycin

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Identification
Molecular formula
C37H67NO13
CAS number
114-07-8
IUPAC name
(1R,5S,6S,9S,12R)-22-(1-hydroxyethyl)-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol
State
State

At room temperature, erythromycin is a solid. It is typically processed into tablet or capsule form but can also be found as a powder for reconstitution into a liquid formulation.

Melting point (Celsius)
135.00
Melting point (Kelvin)
408.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
733.94g/mol
Molar mass
733.9370g/mol
Density
1.2400g/cm3
Appearence

Erythromycin is a white to off-white crystalline powder that may appear as granules. It is practically odorless and has a bitter taste. When viewed under a microscope, the crystal structure can appear irregularly shaped.

It is known for its poor water solubility and may also appear in solution form when dissolved for pharmaceutical preparations.

Comment on solubility

Solubility of (1R,5S,6S,9S,12R)-22-(1-hydroxyethyl)-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol

The solubility of the compound, (1R,5S,6S,9S,12R)-22-(1-hydroxyethyl)-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol, can be assessed on multiple fronts. Its complex molecular structure, characterized by multiple functional groups and rings, plays a pivotal role in determining its solubility.

Key factors that influence its solubility include:

  • Polarity: The presence of hydroxyl groups increases the compound's polarity, enhancing its solubility in polar solvents like water.
  • Hydrogen Bonding: The capability to form hydrogen bonds with solvents contributes significantly to solubility.
  • Molecular Size: Larger and bulkier molecules may experience limitations in solubility due to steric hindrance.

It is also important to consider the following:

  • Compatibility with Solvents: The compound may dissolve better in organic solvents due to its hydrophobic regions.
  • Temperature Effects: Temperature increases may enhance solubility, particularly for solid forms.

As Solubility is often context-dependent, understanding how this compound behaves in various environments and solutions is critical for applications in chemical science.

Interesting facts

Interesting Facts about (1R,5S,6S,9S,12R)-22-(1-hydroxyethyl)-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol

This fascinating compound is a member of a unique class of molecules that showcases the intricate design found in nature. Its complex structure is characterized by multiple rings and functional groups, highlighting the beauty of organic chemistry in synthesizing elaborate compounds. Here are some engaging facts about this intriguing molecule:

  • Structural Complexity: The compound features a highly intricate framework known as a hexacyclic system, which is rare and interesting in chemical synthesis.
  • Functional Diversity: The presence of hydroxyl and aza groups in its structure offers potential chemical reactivity and interactions, making it a candidate for various applications in medicinal chemistry.
  • Natural Products: Such complex compounds often resemble those found in natural product chemistry, which can sometimes lead to discovering novel biological activities.
  • Stereochemistry: With specific chiral centers, the compound exhibits unique stereochemical properties, impacting its reactivity and the interactions it may have with biological systems.

As a student or researcher, consider the implications of such molecular complexity:

  1. How might the structure influence its biological activity?
  2. What strategies could be employed to synthesize such a compound in the laboratory?
  3. In what ways could this compound serve as a template for designing new pharmaceuticals?

The exploration of such compounds can lead to a deeper understanding of both chemical principles and biological mechanisms, emphasizing the interconnectedness of chemistry and the life sciences.