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Tigecycline

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Identification
Molecular formula
C29H39N5O8
CAS number
220620-09-7
IUPAC name
(1R,6R,7S,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione
State
State

At room temperature, tigecycline is in solid state as a crystalline powder.

Melting point (Celsius)
264.00
Melting point (Kelvin)
537.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
585.64g/mol
Molar mass
585.6440g/mol
Density
1.4000g/cm3
Appearence

Tigecycline is a yellow to orange crystalline powder that is hygroscopic. It has no distinctive odor.

Comment on solubility

Solubility of (1R,6R,7S,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione

The solubility of this complex organic compound can be influenced by several factors due to its unique structure. Understanding its solubility characteristics is crucial for its applications in various chemical processes. Here are some key points regarding its solubility:

  • Polarity: The presence of multiple hydroxyl groups (–OH) suggests that the compound could exhibit polar characteristics, potentially enhancing its solubility in polar solvents like water.
  • Hydrophobic Regions: Conversely, its hydrophobic features due to the carbon chains may hinder solubility in highly polar solvents, indicating that it may be more soluble in organic solvents like ethanol or chloroform.
  • pH Dependence: The solubility could also be affected by the pH of the solution, as ionization of hydroxyl groups may play a role under different pH conditions.
  • Temperature Effects: Generally, solubility can improve with an increase in temperature, which could be relevant for this compound during practical applications.

In summary, while the exact solubility of (1R,6R,7S,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione may not be straightforward to quantify, its solubility is likely to vary significantly based on solvent type, pH levels, and temperature conditions.

Interesting facts

Interesting Facts about (1R,6R,7S,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione

This compound is a fascinating member of the bicyclic and tricyclic classes, showcasing the complexity and diversity of organic chemistry. Its unique structure grants it several intriguing properties and potential applications:

  • Natural Product Derivative: Many complex organic compounds, including this one, are often inspired by natural products found in plants and microorganisms, making them prime candidates for research in the field of natural product synthesis.
  • Biological Activity: Compounds with similar structural features have been studied for various biological activities, including anticancer, anti-inflammatory, and antimicrobial properties, leading to potential therapeutic uses.
  • Synthetic Challenges: The synthesis of such intricate compounds is a challenging task that requires advanced techniques in organic synthesis. The building of multiple stereocenters can be particularly difficult and often involves innovative methodologies.
  • Structure-Activity Relationship (SAR): The various functional groups within this compound can be modified to better understand their influence on biological activity, making them valuable for SAR studies.
  • Applications in Drug Development: Due to its structural novelty, researchers may explore its potential as a lead compound in drug discovery, paving the way for new therapeutic agents.

In conclusion, the exploration of (1R,6R,7S,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione not only offers insights into its unique chemical properties but also opens up avenues for scientific research and potential real-world applications. As stated by renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." Engaging with such compounds can certainly inspire innovative thinking in the world of chemistry.

Synonyms
Prestwick0_000637
Prestwick1_000637
TimTec1_004158
SPBio_002853
LSM-2938
AKOS030254943
Q27164507