Naloxone | Solubility of Things

Identification

Molecular formula

C₁₉H₂₁NO₄

CAS number

465-65-6

IUPAC name

(1R,9S,10R)-17-(cyclopropylmethyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol

State

At room temperature, naloxone is typically found in a solid state, often in crystalline powder form. It is also available in prepared solutions for use in medical settings.

Melting point (Celsius)

194.00

Melting point (Kelvin)

467.15

Boiling point (Celsius)

451.00

Boiling point (Kelvin)

724.15

General information

Molecular weight

327.39g/mol

Molar mass

327.3860g/mol

Density

1.2380g/cm³

Appearence

Naloxone is a white to slightly off-white crystalline powder. It is often encountered in a solution form as an injectable or nasal spray for medical use.

Comment on solubility

Solubility of (1R,9S,10R)-17-(cyclopropylmethyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol

The solubility of (1R,9S,10R)-17-(cyclopropylmethyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol can be quite complex due to its unique structural characteristics. Understanding its solubility involves considering several factors:

Polarity: Compounds with polar functional groups typically display increased solubility in polar solvents, while nonpolar compounds show better solubility in nonpolar environments.
Hydrogen Bonding: The presence of hydroxyl (-OH) groups may facilitate interactions with water, potentially enhancing solubility.
Molecular Interactions: The intricate three-dimensional structure and steric effects can hinder solubility, especially in aqueous environments.
Crystal Lattice Energy: A significant factor in solubility is the energy required to break apart the solid structure into individual molecules.
Temperature: Solubility often increases with temperature, thus influencing the behavior of the compound in various conditions.

In summary, while specific solubility data for this compound may be challenging to find, its solubility is likely influenced by the balance of these factors. As the saying goes, “Like dissolves like,” so understanding the polarity and structure is key to predicting its solubility in various solvents. Therefore, additional empirical studies would be essential to establish precise solubility characteristics.

Interesting facts

Interesting Facts About (1R,9S,10R)-17-(cyclopropylmethyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol

This compound, with a complex structure, belongs to a class of organic molecules known for their diverse applications in pharmaceuticals and biochemistry. Here are some fascinating aspects of this particular compound:

Structural Intricacies: The presence of multiple stereocenters and the unique bicyclic and tricyclic framework contribute to its three-dimensional shape, influencing how it interacts with biological systems.
Biological Significance: Compounds with similar frameworks often exhibit significant biological activity, making this compound a candidate for further exploration in medicinal chemistry.
Potential Applications: Research on such complexes can lead to advancements in drug discovery, particularly for conditions that require finely-tuned molecular interactions, such as cancer or neurological disorders.
Chirality Matters: The specific orientation of its chiral centers is crucial, as even minor changes in stereochemistry can dramatically alter the compound's biological activity.
Synthesis Challenges: The synthesis of multi-cyclic compounds like this one can be challenging, paving the way for innovative synthetic techniques and methodologies that chemists employ to create complex organic structures.

As researchers delve into the world of structure-activity relationships, compounds like (1R,9S,10R)-17-(cyclopropylmethyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol serve as pivotal points of study.
The journey of understanding and utilizing these fascinating molecular structures continues to present new frontiers in the realm of chemistry.