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Sibutramine

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Identification
Molecular formula
C17H29NO
CAS number
106650-56-0
IUPAC name
(1S)-2-[[(1R)-1-methylpropyl]amino]-1-tetralin-6-yl-ethanol
State
State

Sibutramine is generally found as a solid at room temperature. It may be available as a powder or in crystalline form.

Melting point (Celsius)
193.50
Melting point (Kelvin)
466.65
Boiling point (Celsius)
407.30
Boiling point (Kelvin)
680.45
General information
Molecular weight
277.43g/mol
Molar mass
277.4080g/mol
Density
1.0368g/cm3
Appearence

Sibutramine is a crystalline solid that is white to off-white in color. It typically appears as a fine powder.

Comment on solubility

Solubility of (1S)-2-[[(1R)-1-methylpropyl]amino]-1-tetralin-6-yl-ethanol

The solubility of the compound (1S)-2-[[(1R)-1-methylpropyl]amino]-1-tetralin-6-yl-ethanol is influenced by several factors due to its complex structure. Understanding these factors can help predict its behavior in various solvents.

Factors Influencing Solubility:

  • Polarity: The presence of hydroxyl groups and amine functionalities suggests that this compound may exhibit moderate polarity, which often correlates with solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds can enhance solubility in solvents capable of similar interactions, such as alcohols.
  • Molecular Size: The relatively large size of the tetralin moiety may hinder solubility in non-polar solvents, limiting its effective solubility range.

In general, one might expect (1S)-2-[[(1R)-1-methylpropyl]amino]-1-tetralin-6-yl-ethanol to be more soluble in:

  • Polar organic solvents (e.g., methanol, ethanol).
  • Aqueous solutions, particularly at elevated temperatures.

However, precise solubility data would require experimental determination, as the solubility can vary significantly based on the solvent conditions and temperature. As noted in the field of chemistry, “the solution to solubility often lies in the intermolecular interactions present”, emphasizing the importance of thorough analysis when assessing solubility characteristics.

Interesting facts

Fascinating Insights into (1S)-2-[[(1R)-1-methylpropyl]amino]-1-tetralin-6-yl-ethanol

(1S)-2-[[(1R)-1-methylpropyl]amino]-1-tetralin-6-yl-ethanol is a compound that showcases the intricate relationships between chemical structures and biological activities. As a student or scientist delving into organic chemistry, you might find the following aspects particularly intriguing:

  • Chiral Centers: This compound features multiple chiral centers, which means it can exist in different stereoisomeric forms. Stereoisomers can exhibit vastly different biological activities, making stereochemistry a critical aspect of drug design.
  • Functional Groups: The presence of both an amine and an alcohol group contributes to its reactivity. The amine moiety often plays a role in binding interactions with biological targets, such as receptors and enzymes.
  • Applications in Research: Compounds like this are often studied for their potential as therapeutic agents, particularly in neuroscience. Their structural similarities to neurotransmitters make them suitable candidates for drug development aimed at treating psychiatric disorders.
  • Cyclic Structure: The tetralin moiety presents a unique cyclic structure that can influence the overall conformation and binding affinity of the molecule, adding another layer of complexity to its pharmacological profile.
  • Importance of Ethanol Group: The ethanol function may enhance solubility and facilitate interactions with biological systems, making it a valuable characteristic in drug formulation technology.

As you explore the chemical world, remember that each compound tells a story—from its synthesis to its potential applications. In the case of (1S)-2-[[(1R)-1-methylpropyl]amino]-1-tetralin-6-yl-ethanol, understanding its structural attributes is key to unlocking its secrets and potential therapeutic properties.