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Benzylpenicillin

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Identification
Molecular formula
C16H18N2O4S
CAS number
61-33-6
IUPAC name
[(1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate;naphthalene-2-sulfonic acid
State
State

At room temperature, benzylpenicillin typically exists as a solid. However, it is often used in aqueous solutions for clinical applications. It is important to store the compound in a cool, dry place to prevent degradation.

Melting point (Celsius)
240.00
Melting point (Kelvin)
513.15
Boiling point (Celsius)
265.00
Boiling point (Kelvin)
538.15
General information
Molecular weight
356.42g/mol
Molar mass
356.4230g/mol
Density
1.3000g/cm3
Appearence

Benzylpenicillin generally appears as a crystalline or powder-like solid. It is usually white or off-white in color. Benzylpenicillin, also known as penicillin G, can come in various salt forms which can have different appearances. For example, its sodium or potassium salt forms tend to be hygroscopic and may differ slightly in texture.

Comment on solubility

Solubility of [(1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate and naphthalene-2-sulfonic acid

The solubility characteristics of the compound [(1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate and naphthalene-2-sulfonic acid can be quite intricate due to their complex molecular structures. Understanding their solubility is essential for various chemical applications.

Key Factors Affecting Solubility:

  • Polarity: Compounds that contain polar functional groups typically exhibit higher solubility in polar solvents like water.
  • Hydrogen Bonding: The presence of hydrogen bonding can significantly enhance solubility by stabilizing solute-solvent interactions.
  • Molecular Size: Larger molecules may have limited solubility due to steric hindrance, impacting their ability to interact with solvent molecules efficiently.

When considering the solubility of these compounds:

  1. The propanoate moiety may increase solubility in organic solvents due to its hydrophobic characteristics.
  2. Naphthalene-2-sulfonic acid, being an aromatic sulfonic acid, is generally more soluble in water than naphthalene itself. This is due to the sulfonic acid group, which enhances solubility in polar solvents.

While both compounds exhibit unique solubility traits, they may not be very soluble in non-polar solvents, making their interaction with water and polar organic solvents critical. Thus, understanding these solubility properties is crucial for optimizing their use in various chemical formulations and applications.

Interesting facts

Interesting Facts About [(1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate and Naphthalene-2-sulfonic Acid

This fascinating compound showcases the intricate world of organic synthesis and medicinal chemistry. Here are some intriguing points about it:

  • Chirality Matters: The compound has specific stereochemistry denoted by the 1S and 2R configurations. Chirality plays a crucial role in pharmaceuticals, as the different enantiomers can exhibit vastly different biological activities.
  • Functional Diversity: Featuring both aromatic and aliphatic moieties, this compound is a great example of how modifying side chains can significantly alter the physical and chemical properties.
  • Applications in Drug Development: Compounds similar to this one are often explored for their potential therapeutic benefits, especially in the realm of neuropharmacology. The dimethylamino group can influence the compound's interaction with neurotransmitter receptors.
  • Interaction with Naphthalene-2-Sulfonic Acid: This sulfonic acid is known for its utility as a reagent in organic synthesis and a component in acid-base studies. Its interaction with the main compound can lead to intriguing insights into solubility and reactivity.
  • Research Significance: Compounds of this nature may serve as key intermediates in developing more complex structures, aiding in the exploration of novel therapeutic agents.

As chemistry students and scientists, we are continually challenged to understand and manipulate such compounds to enhance their applications in real-world scenarios. The interplay of structure and function remains a compelling area of research!

Synonyms
Propoxyphene napsylate anhydrous
Darvon N
[(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate;naphthalene-2-sulfonic acid
Propoxyphene-N
(+)- Propoxyphene napsylate
Propoxyphene 2-naphthalenesulfonate
EINECS 241-205-7
UNII-5O7IW35N3C
2-Butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, propionate, 2-naphthalenesulfonate
SCHEMBL9297768
PROPOXYPHENE NAPSYLATE, ANHYDROUS
Benzeneethanol, alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, propanoate (ester), (1S,2R)-, 2-naphthalenesulfonate (salt)
Benzeneethanol, alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, propanoate (ester), (S-(R*,S*))-, 2-naphthalenesulfonate (salt)
Naphthalene-2-sulphonic acid, compound with (S-(R*,S*))-1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propionate (1:1)
PD051776
Q27262632