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Lisdexamfetamine dimesylate

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Identification
Molecular formula
C15H25NO2
CAS number
608137-32-3
IUPAC name
[(1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate;naphthalene-2-sulfonic acid;hydrate
State
State

At room temperature, lisdexamfetamine dimesylate is typically a solid, existing as a crystalline powder under standard conditions.

Melting point (Celsius)
105.20
Melting point (Kelvin)
378.30
Boiling point (Celsius)
391.60
Boiling point (Kelvin)
664.80
General information
Molecular weight
263.36g/mol
Molar mass
263.3630g/mol
Density
1.0929g/cm3
Appearence

Lisdexamfetamine dimesylate appears as a white to off-white powder. It is characterized by its crystalline nature and is usually without any significant odor.

Comment on solubility

Solubility of [(1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate; naphthalene-2-sulfonic acid; hydrate

The solubility of the compound [(1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate; naphthalene-2-sulfonic acid; hydrate can be quite intriguing due to its complex molecular structure. Understanding solubility involves various factors, which may include:

  • Polarity: The balance of polar and non-polar groups in the molecule significantly affects its solubility in polar solvents like water or non-polar solvents like hexane.
  • pH Sensitivity: The presence of functional groups may lead to solubility changes under different pH conditions, particularly for the sulfonic acid component.
  • Hydration: Being a hydrate, the compound may dissolve better in aqueous environments, where water molecules can interact with hydroxyl or charged functional groups.

In general, compounds like this one with intricate structures tend to exhibit variable solubility patterns depending on solvent type and temperature. As stated in chemical literature, “the solubility of various compounds is not merely a question of chemical composition, but also of molecular interaction dynamics.” This illustrates that both the fundamental chemical nature and the environmental conditions are vital in determining solubility.

Therefore, experimentation is usually required to ascertain specific solubility properties effectively. When considering practical applications, such as synthesis or formulation, one must keep these factors in mind to predict how this compound behaves in solution.

Interesting facts

Interesting Facts about [(1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate; naphthalene-2-sulfonic acid; hydrate

This compound presents an intriguing blend of functional groups that grant it various properties, making it a subject of interest in both synthetic and medicinal chemistry. Below are some captivating aspects that highlight its importance:

  • Structural Diversity: The presence of both a propanoate moiety and a naphthalene-2-sulfonic acid enhances the compound’s structural diversity, allowing it to interact favorably in different chemical environments.
  • Pharmaceutical Potential: The dimethylamino group often serves as a crucial pharmacophore in drug design, signaling possible applications in the development of therapeutic agents, especially in neuromodulation.
  • Solvate Behavior: Being a hydrate, the compound can exhibit unique solvatomorphic behavior. This implies that its properties, such as stability and reactivity, might vary considerably based on the hydration state.
  • Applications in Dyes: Naphthalene derivatives are widely employed in dye chemistry due to their robust aromatic structure, suggesting that this compound may have potential uses in textile or biological staining applications.
  • Catalytic Role: Compounds featuring sulfonate groups often act as good catalysts or intermediates in organic reactions, particularly in reactions involving electrophiles and nucleophiles.
  • Importance in Analytical Chemistry: Compounds like this can serve as markers or indicators in analytical applications due to their unique structural characteristics that make them detectable by various analytical techniques.

In conclusion, the complexity of [(1S,2R)-1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate; naphthalene-2-sulfonic acid; hydrate not only showcases the versatility of synthetic organic chemistry but also opens doors to a myriad of possible applications across different scientific fields. As students or researchers delve deeper into this compound, they are likely to uncover even more fascinating facets that contribute to its chemical significance.

Synonyms
d-Propoxyphene napsylate hydrate
26570-10-5
Dextropropoxyphene napsilate
Propoxyphene napsylate [USAN]
Propoxyphene napsylate cii
38M219L1OJ
Dexofen
(alphaS,1R)-alpha-(2-(Dimethylamino)-1-methylethyl)-alpha-phenylphenethyl propionate compound with 2-naphthalenesulfonic acid (1:1) monohydrate
[(2S,3R)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate;naphthalene-2-sulfonic acid;hydrate
Propoxyphene napsylate (USAN)
UNII-38M219L1OJ
S-9700
Propoxyphene napsylate [USAN:USP]
(alphaS,1R)-alpha-[2-(Dimethylamino)-1-methylethyl]-alpha-phenylphenethyl propionate compound with 2-naphthalenesulfonic acid (1:1) monohydrate
Darvon-N (TN)
SCHEMBL41620
propoxyphene napsylate hydrate
2-Butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, propionate (ester), 2-naphthalenesulfonate, monohydrate, (2S,3R)-
CHEMBL3989716
SCHEMBL29498782
DTXSID70949417
Propoxyphene napsylate monohydrate
PROPOXYPHENE NAPSYLATE [VANDF]
DB09396
DEXTROPROPOXYPHENE NAPSILATE [MART.]
PROPOXYPHENE NAPSYLATE [ORANGE BOOK]
DEXTROPROPOXYPHENE NAPSILATE [WHO-DD]
PROPOXYPHENE NAPSYLATE [USP IMPURITY]
DEXTROPROPOXYPHENE NAPSILATE MONOHYDRATE
DEXTROPROPOXYPHENE NAPSYLATE MONOHYDRATE
D05632
PROPOXYPHENE NAPSYLATE MONOHYDRATE [MI]
Q27122461
Naphthalene-2-sulfonic acid--4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl propanoate--water (1/1/1)