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Vancomycin

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Identification
Molecular formula
C66H75Cl2N9O24
CAS number
1404-90-6
IUPAC name
(1S,2R,18R,22S,25R,28R,40R)-48-[(2R,3S,4R,5R,6S)-3-[(2R,4R,5R,6R)-4-amino-5-hydroxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-22-(2-amino-2-oxo-ethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34(39),35,37,46,49-pentadecaene-40-carboxylic acid
State
State

Solid at room temperature.

Melting point (Celsius)
0.00
Melting point (Kelvin)
0.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
1485.71g/mol
Molar mass
1 485.7130g/mol
Density
1.3000g/cm3
Appearence

Vancomycin is a white to off-white crystalline powder. It is usually presented in a powdered form for reconstitution into a solution for injection.

Comment on solubility

Solubility of (1S,2R,18R,22S,25R,28R,40R)-48-[(2R,3S,4R,5R,6S)-3-[(2R,4R,5R,6R)-4-amino-5-hydroxy-4,6-dimethyl-tetrahydropyran-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-22-(2-amino-2-oxo-ethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[[[2R]-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34(39),35,37,46,49-pentadecaene-40-carboxylic acid

This complex compound exhibits varying degrees of solubility, influenced by its intricate molecular structure. Understanding solubility is crucial as it determines the compound's behavior in different environments. Here are some key points regarding its solubility:

  • Polarity: The presence of multiple hydroxyl groups increases the potential for hydrogen bonding with water, suggesting that it may exhibit enhanced solubility in polar solvents.
  • Hydrophobic regions: The compound contains hydrophobic sections, which may decrease overall solubility in aqueous mediums.
  • pH sensitivity: Solubility may vary significantly depending on the pH of the solution, particularly due to the presence of amino and carboxylic acid functional groups.
  • Concentration effects: At higher concentrations, solubility may be affected by aggregation or precipitation, which can complicate practical applications.

As noted in the field, "The interaction between solute and solvent is a delicate balance." Thus, the solubility of this compound can be described as being complex and multifactorial, requiring thorough investigation across various environments to fully understand its properties.

Interesting facts

Interesting Facts about the Compound

This compound, with its intricate structure, represents a fascinating realm of chemistry with multiple applications and insights into molecular interactions. Here are some notable aspects:

  • Complex Structure: The structure of this compound showcases the beauty of organic chemistry, exhibiting a unique arrangement of multiple functional groups and chiral centers. This complexity often leads to distinctive pharmacological properties.
  • Biological Relevance: Compounds like this are often studied for their potential therapeutic effects. Researchers are keen on exploring how such structures interact with biological macromolecules, impacting processes like cellular signaling.
  • Diversity of Functional Groups: The presence of various functional groups, including amino acids and polyols, makes it a prime candidate for studies in medicinal chemistry. These groups can significantly influence the compound's reactivity and biological activity.
  • The Role of Chirality: With multiple stereocenters, this compound illustrates the importance of chirality in pharmaceuticals. Chiral compounds often show different biological activities based on their stereochemistry, making them critical in drug design.
  • Potential Applications: This type of compound may find uses in fields like materials science, nanotechnology, and drug delivery systems. Their unique properties can be harnessed for advanced applications in biomedicine.

To quote a famous chemist, "Chemistry is the study of transformation, and this compound embodies the potential for transformation at the molecular level." The ongoing exploration of such compounds continues to reveal the intricate dance of atoms and their significance in both nature and technology.