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Ephedrine

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Identification
Molecular formula
C10H15NO
CAS number
299-42-3
IUPAC name
(1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol
State
State

Ephedrine is generally a solid at room temperature, existing as a crystalline powder.

Melting point (Celsius)
34.00
Melting point (Kelvin)
307.15
Boiling point (Celsius)
255.00
Boiling point (Kelvin)
528.15
General information
Molecular weight
165.23g/mol
Molar mass
165.2330g/mol
Density
1.1682g/cm3
Appearence

Ephedrine is typically found as a white, crystalline powder or as colorless crystals. It is frequently encountered in its hydrochloride or sulfate salt forms when used for medicinal purposes.

Comment on solubility

Solubility of (1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol

The solubility of the compound (1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol can be influenced by various factors, including its molecular structure and the presence of functional groups.

In general, compounds with amino groups like the methylamino group in this compound tend to exhibit different solubility characteristics. Here are some key points regarding its solubility:

  • Polarity: The presence of both an amino group and a hydroxyl group suggests that the molecule is relatively polar, which can enhance solubility in polar solvents such as water.
  • Hydrogen Bonding: The -NH group can engage in hydrogen bonding with water molecules, improving its solubility.
  • Organic Solvents: It may also exhibit solubility in various organic solvents due to its hydrophobic phenyl ring, which can interact favorably with non-polar solvents.

To summarize, the solubility of (1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol is expected to be:

  • High in polar solvents like water due to hydrogen bonding.
  • Moderate in non-polar organic solvents through hydrophobic interactions.

Understanding the solubility of this compound is crucial for its applications in various chemical reactions and pharmaceutical formulations. As with many compounds, *individual testing* for solubility in specific solvents can provide valuable insights.

Interesting facts

Exploring (1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol

(1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol, commonly referred to as a chiral compound, plays an intriguing role in the field of organic chemistry and pharmacology. Here are some fascinating facts about this compound:

  • Chirality: This compound features a specific three-dimensional arrangement of atoms known as chirality, which is key in determining its biological activity. Chirality can lead to significant differences in the effects of the compound in biological systems, as different enantiomers can interact uniquely with enzymes and receptors.
  • Pharmaceutical Relevance: The presence of a phenyl ring and a methylamino group positions this compound as a candidate for drug design. Such compounds can be studied for their potential therapeutic effects, especially in the central nervous system or in pain management.
  • Structure Activity Relationship (SAR): Scientists often explore the relationship between the chemical structure of such compounds and their biological activity. This research helps in enhancing the efficacy and reducing side effects of pharmaceuticals by modifying the compound's structure.
  • Analytical Techniques: To study (1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol, chemists may employ a range of analytical techniques such as NMR spectroscopy and mass spectrometry, which provide insights into its structure and purity.
  • Historical Context: Compounds like this are not only central to modern drug discovery but also have historical significance, as the understanding of amines and alcohols has evolved through the centuries, shaping the way pharmacology is approached today.

In summary, (1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol is a compound that exemplifies the intersections between chemistry and biology. Its chirality and structural characteristics open doors to scientific exploration and potential therapeutic applications. As one researcher noted, "The future of medicine lies in understanding and manipulating the chiral nature of compounds."

Synonyms
PSEUDOEPHEDRINE
(+)-Pseudoephedrine
d-Pseudoephedrine
Isoephedrine
trans-Ephedrine
d-Isoephedrine
Psi-ephedrin
Psi-ephedrine
(+)-threo-Ephedrine
d-psi-Ephedrine
Sudafed
Pseudoefedrina
90-82-4
L(+)-psi-Ephedrine
L-(+)-Pseudoephedrine
(+)-psi-Ephedrine
Pseudoephedrinum
(+)-(1S,2S)-Pseudoephedrine
Besan
Pseudoephedrine d-form
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
Neodurasina
Acunaso
Pseudoephedrine (D)
(1S,2S)-(+)-Pseudoephedrine
(1S,2S)-Pseudoephedrine
d-psi-2-Methylamino-1-phenyl-1-propanol
Pseudoefedrina [INN-Spanish]
Pseudoephedrinum [INN-Latin]
psi-Ephedrine, (+)-
Isoephedrine, d-
Pseudoephedrine, (+)-
pseudophedrine sulphate
HSDB 3177
UNII-7CUC9DDI9F
7CUC9DDI9F
alpha-(1-(Methylamino)ethyl)benzyl alcohol
EINECS 202-018-6
CHEBI:51209
Pseudoephedrine (INN)
Pseudoephedrine, L-(+)-
DTXSID0023537
Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (S-(R*,R*))-
EC 202-018-6
(+) threo-2-(methylamino)-1-phenyl-1-propanol
Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alpha-S)-
Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, (.alpha.S)-
1-(S),2-(R)-ERYTHRO-(+)-EPHEDRINE
PSEUDOEPHEDRINE [INN]
Pseudoefedrina (INN-Spanish)
Pseudoephedrinum (INN-Latin)
Pseudoephedrine [INN:BAN]
PSEUDOEPHEDRINE (MART.)
PSEUDOEPHEDRINE [MART.]
Pseudoephedrine Ephedrine
Neodurasina (TN)
Acunaso (TN)
Pseudoephedrine polistirex
BENZENEMETHANOL, .ALPHA.-((1S)-1-(METHYLAMINO)ETHYL)-, (.ALPHA.S)-
(I)-Ephedrin
ephedrine-(racemic)
(+) pseudoephedrine
d-Pseudoephedrine base
Spectrum_000878
Spectrum2_001303
Spectrum3_001771
Spectrum4_001162
Spectrum5_000650
Lopac-E-3250
PSEUDOEPHEDRINE(D)
(1S,2S) pseudoephedrine
(1S,2S)-2-methylamino-1-phenylpropan-1-ol
(1s, 2s) pseudoephedrine
(1S,2S)-2-methylamino-1-phenyl-propan-1-ol
SCHEMBL4368
CHEMBL1590
PSEUDOEPHEDRINE [MI]
(1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol
BSPBio_003261
KBioGR_001763
KBioSS_001358
BIDD:GT0817
DivK1c_000451
PSEUDOEPHEDRINE [HSDB]
SPBio_001365
PSEUDOEPHEDRINE [VANDF]
DTXCID003537
GTPL7286
BENZENEMETHANOL, .ALPHA.-(1-(METHYLAMINO)ETHYL)-, (S-(R*,R*))-
PSEUDOEPHEDRINE [WHO-DD]
KBio1_000451
KBio2_001358
KBio2_003926
KBio2_006494
KBio3_002762
(1s, 2s)-(+)-pseudoephedrine
R01BA02
NINDS_000451
Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alphaS)-
PDSP1_001347
AKOS025401512
DB00852
IDI1_000451
(1S,2S)-(+)-Pseudoephedrine, 98%
NCGC00015408-01
NCGC00178180-01
NCI60_002955
SBI-0051498.P003
(+)-Pseudoephedrine, 1mg/ml in Acetonitrile
NS00067939
C02765
D08449
Q263958
BRD-K84175871-003-02-2
EPHEDRINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]
(alphaS)-alpha-((1R)-1-(METHYLAMINO)ETHYL)BENZENEMETHANOL
(.ALPHA.S)-.ALPHA.-((1R)-1-(METHYLAMINO)ETHYL)BENZENEMETHANOL
202-018-6