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Methamphetamine Hydrochloride

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Identification
Molecular formula
C10H15ClNO
CAS number
300-42-5
IUPAC name
(1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol;hydrochloride
State
State

In its pure form, methamphetamine hydrochloride is a solid at room temperature and pressure. Typically, it exists in powder or crystalline form, and these forms are stable at room temperature.

Melting point (Celsius)
170.00
Melting point (Kelvin)
443.15
Boiling point (Celsius)
215.30
Boiling point (Kelvin)
488.45
General information
Molecular weight
185.70g/mol
Molar mass
185.7000g/mol
Density
1.0080g/cm3
Appearence

At room temperature, methamphetamine hydrochloride typically appears as a colorless or white crystalline powder. It is not particularly hygroscopic and can also be found in the form of clear crystals or granules, resembling shards of glass. These crystals have a bitter taste.

Comment on solubility

Solubility of (1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol;hydrochloride

The solubility of (1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol;hydrochloride is influenced by several factors, primarily due to its ionic nature when in the hydrochloride form. Hydrochloride salts are known for their enhanced solubility in polar solvents, particularly water.

Key points regarding the solubility of this compound include:

  • Water Solubility: Hydrochloride salts, like this compound, tend to dissolve readily in water. This is due to the presence of the ionic HCl component that facilitates solvation.
  • Solvent Polarity: The compound's solubility can be significantly higher in polar solvents. Non-polar solvents may not dissolve this compound effectively.
  • Temperature Dependence: As with many organic compounds, increasing temperature typically enhances solubility. It's advisable to test solubility at various temperatures to optimize conditions.
  • pH Influence: The pH of the solution can also affect solubility, especially if the compound can act as a weak base or acid in different environments.

In conclusion, one can expect (1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol;hydrochloride to show good solubility in water and other polar solvents, making it a suitable candidate for formulations requiring aqueous solutions.

Interesting facts

Interesting Facts about (1S,2S)-2-(Methylamino)-1-phenyl-propan-1-ol; Hydrochloride

(1S,2S)-2-(Methylamino)-1-phenyl-propan-1-ol; hydrochloride is an intriguing compound notable for its activity in the realm of pharmaceuticals. Here are some fascinating aspects of this compound:

  • Pharmacological Significance: This compound is often studied for its potential as an antidepressant and stimulant, playing a role in modulating the levels of neurotransmitters in the brain.
  • Chirality: The structure of this compound exhibits chirality, a property that is crucial in the field of medicinal chemistry. The specific stereochemistry, designated by (1S,2S), can greatly influence the efficacy and safety of the drug, as different enantiomers may have different biological activities.
  • Functional Groups: Featuring both an amino group and a hydroxyl group, this compound belongs to a class of compounds known for their ability to interact with various biochemical pathways, making it a subject of interest in drug design and synthesis.
  • Use in Research: It serves as a significant intermediate in the synthesis of more complex pharmacologically active molecules, allowing chemists to develop new therapeutic agents.
  • Potential Side Effects: As with many compounds affecting neurotransmitter levels, understanding the side effects and therapeutic window is of utmost importance, emphasizing the role of thorough research and clinical trials.

In summary, (1S,2S)-2-(methylamino)-1-phenyl-propan-1-ol; hydrochloride is more than just a chemical compound; it is a key player in the development of medications and an example of how subtle changes in molecular structure can have profound effects on pharmacological activity. As the field of medicinal chemistry progresses, compounds like this continue to unveil their secrets, contributing to the advancement of healthcare.

Synonyms
PSEUDOEPHEDRINE HYDROCHLORIDE
Pseudoephedrine Hcl
345-78-8
Rhinalair
Otrinol
Novafed
Sudomyl
Tussaphed
First sign
Sinufed
Sudafed
Sudafed hydrochloride
d-Pseudoephedrine hydrochloride
CoAdvil
(+)-Pseudoephedrine hydrochloride
Symptom 2
Sudafed 12 Hour
Besan
Nexafed
Pseudophedrine hydrochloride
Suphedrine
Galsud
Sun mark sinus
Sudafed 24 Hour
CPDD 0050
1S,2S-(+)-Pseudoephedrine hydrochloride
L(+)-Pseudoephedrine hydrochloride
UNII-6V9V2RYJ8N
EINECS 206-462-1
6V9V2RYJ8N
NSC 33634
NSC-33634
Topcare 12 hour decongestant
NSC 106567
NSC-106567
Efidac 24
GALPSEUD
Pseudoephedrine, hydrochloride, L-(+)-
CHEBI:8604
D-(alpha-(1-Methylamino)ethyl)benzyl alcohol hydrochloride
EC 206-462-1
NSC33634
Benzenemethanol, alpha-(1-(methylamino)ethyl)-, hydrochloride, (S-(R*,R*))-
NSC106567
Pseudoephedrine hydrochloride [USAN:USP]
(+)-Pseudoephedrine.HCl
Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, hydrochloride, (alphaS)-
Benzenemethanol, alpha-(1-(methylamino)ethyl)-, hydrochloride, (S-(theta,theta))-
MYFED COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol hydrochloride
ACTAHIST COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
ACTIFED COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
ALEVE-D COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
ALLERFED COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
CORPHED COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
HISTAFED COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
ISOCLOR COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Pseudoephedrine, (+)-
TRIPHED COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
ZYRTEC-D COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
ALLEGRA-D COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
BROMFED-DM COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
MUCINEX D COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
SEMPREX-D COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
TRIACIN-C COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
TRILITRON COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
BROMANATE DM COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
DIMETANE-DX COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
SINE-AID IB COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Pseudoephedrine, L-(+)-
Dorcol
ADVIL ALLERGY SINUS COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
CODIMAL-L.A. 12 COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
L-(+)-Pseudoephedrine hydrochloride
CHILDREN'S ADVIL COLD COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
CHILDREN'S MOTRIN COLD COMPONENT PSEUDOEPHEDRINE HYDROCHLORIDE
Deconsal II
Sudafed Liquid, Children's
PediaCare Decongestant Drops
Pseudoephedrine hydrochloride (USAN:USP)
Benzenemethanol, hydrochloride, S-(R,R)-
WLN: QYR & Y1 & M1 & GH-L
Dimetapp Decongestant
PSEUDOEPHEDRINE HYDROCHLORIDE (MART.)
PSEUDOEPHEDRINE HYDROCHLORIDE [MART.]
Actifed Sinus Daytime
PSEUDOEPHEDRINE HYDROCHLORIDE (USP-RS)
PSEUDOEPHEDRINE HYDROCHLORIDE [USP-RS]
Benzenemethanol, hydrochloride, [S-(R*,R*)]-
PSEUDOEPHEDRINE HYDROCHLORIDE (EP MONOGRAPH)
PSEUDOEPHEDRINE HYDROCHLORIDE (USP MONOGRAPH)
PSEUDOEPHEDRINE HYDROCHLORIDE [EP MONOGRAPH]
PSEUDOEPHEDRINE HYDROCHLORIDE [USP MONOGRAPH]
Pseudoephedrine hydrochloride [USAN]
D-[.alpha.-(1-Methylamino)ethyl]benzyl alcohol hydrochloride
walphed d
Pseudo-time
Zephrex D
Zephrex-D
Childrens Sudafed
Ornex and Maximum Strength Ornex
Sinus Decongestion
pseudoephedrine.hcl
Nasal DecongestantD
Harris Teeter Sinus
Sudafed (TN)
SudoGest 12 Hour
Sinus and Congestion
Nasal Decongestant D
Good Sense Suphedrine
equate sinus 12 hour
RugbyNasal Decongestant
Tylenol Sinus Medication, Maximum Strength
Isoephedrine Hydrochloride
Leader Nasal Decongestant
Picnic Nasal Decongestant
equaline nasal decongestant
SUDAFED Sinus Congestion
Topcare Nasal Decongestant
Contac Day & Night Allergy Sinus Day Caplets
psi-Ephedrine Hydrochloride
Sudogest Nasal Decongestant
12 Hour Nasal Decongestant
Pseudoephedrine HClUnit Dose
SCHEMBL33285
Good Sense Nasal Decongestant
MLS001304069
Good Sense Suphedrine12 Hour
SPECTRUM1500516
Sinus and CongestionNon-Drowsy
Equaline 12 Hour Decongestant
CHEMBL1200724
Sine-Off Maximum Strength No Drowsiness Formula Caplets
DTXSID10889343
DMJSCEPQTCUJQW-KXNXZCPBSA-N
Sudafed Sinus Congestion 12 Hour
Sudafed Sinus Congestion 24 Hour
Childrens SudafedNasal Decongestant
Childrens UniphedNasal Decongestant
HMS1920N04
Pharmakon1600-01500516
Leader 12 Hour Nasal Decongestant
Pseudoephedrine hydrochloride (USP)
CareOne Nasal and Sinus Decongestant
CCG-39241
NSC759616
AKOS027383893
Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (S-(R*,R*))-, hydrochloride
NSC-759616
Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)-
Cvs Health Non-drowsy Nasal Decongestant
Good Neighbor Pharmacy Nasal Decongestant
PSEUDOEPHEDRINE HYDROCHLORIDE [MI]
Rugby Nasal DecongestantNasal Decongestant
SMR000718787
walphed dmaximum strength non drowsy sinus
(+)-Pseudoephedrine hydrochloride, >=98%
nasal decongestantmaximum strength non drowsy
NS00079374
P1654
PSEUDOEPHEDRINE HYDROCHLORIDE [VANDF]
PSEUDOEPHEDRINE HYDROCHLORIDE [WHO-DD]
D00485
Nasal DecongestantMaximum Strength, Non-Drowsy
PSEUDOEPHEDRINE HYDROCHLORIDE [ORANGE BOOK]
Sinus Pressure and Congestion ReliefMaximum Strength
equaline nasal decongestantnon drowsy maximum strength
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF MYFED
Q27108108
Topcare Nasal DecongestantMaximum Strength Non Drowsy
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ACTIFED
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ALEVE-D
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF CORPHED
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ISOCLOR
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF TRIPHED
(+)-Pseudoephedrine hydrochloride, Sigma Reference Standard
HYCOFENIX COMPONENT OF PSEUDOEPHEDRINE HYDROCHLORIDE
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ACTAHIST
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ALLEGRA-D
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ALLERFED
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF BROMFED-DM
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF HISTAFED
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF HYCOFENIX
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF MUCINEX D
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF SEMPREX-D
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF TRIACIN-C
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF TRILITRON
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ZYRTEC-D
(1S,2S)-2-(Methylamino)-1-phenyl-1-propanol Hydrochloride
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF BROMANATE DM
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF DIMETANE-DX
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF SINE-AID IB
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF ADVIL ALLERGY SINUS
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF CODIMAL-L.A. 12
(+)-Pseudoephedrine Hydrochloride 1.0 mg/ml in Methanol (as free base)
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF CHILDREN'S ADVIL COLD
PSEUDOEPHEDRINE HYDROCHLORIDE COMPONENT OF CHILDREN'S MOTRIN COLD
Pseudoephedrine hydrochloride, British Pharmacopoeia (BP) Reference Standard
Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride (1:1), (.alpha.S)-
Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, hydrochloride (1:1), (alphaS)-
Pseudoephedrine hydrochloride, European Pharmacopoeia (EP) Reference Standard
Pseudoephedrine hydrochloride, United States Pharmacopeia (USP) Reference Standard
206-462-1