Skip to main content

Prednisolone furoate

ADVERTISEMENT
Identification
Molecular formula
C25H29FO6
CAS number
21190-99-6
IUPAC name
(1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one
State
State

At room temperature, this compound is in a solid state. It is important to store it in a cool, dry place to prevent any degradation or reaction with moisture.

Melting point (Celsius)
208.00
Melting point (Kelvin)
481.15
Boiling point (Celsius)
285.00
Boiling point (Kelvin)
558.15
General information
Molecular weight
444.48g/mol
Molar mass
444.4770g/mol
Density
1.2800g/cm3
Appearence

The compound is a crystalline solid. It is most commonly found in a white or almost white powder form. It is used in pharmaceutical formulations and thus is handled in conditions ensuring minimal impurity.

Comment on solubility

Solubility Overview

The remarkable compound, (1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one, exhibits intriguing solubility characteristics. Understanding solubility is critical in effectively utilizing the compound in various applications. Here are some key points to consider:

  • Polar vs Non-Polar: The presence of functional groups like hydroxyl (-OH) and the fluorine atom can enhance the polar properties of the molecule, potentially making it more soluble in polar solvents such as water.
  • Solvent Compatibility: The compound may show varying solubility in different solvents. Common solvents to explore include:
    • Water
    • Ethanol
    • Acetone
    • DMSO (dimethyl sulfoxide)
  • pH Influence: Given the acidic nature of some functional groups, the solubility could change significantly based on the pH of the solution, making acidic or basic environments worth investigating.
  • Crystallization: The compound's ability to form crystals may hinder its solubility. Understanding the conditions that lead to crystallization can aid in optimizing solubility.

In conclusion, the solubility profile of this compound is multifaceted, driven by its unique structural characteristics and interactions with various solvent environments. Further experimental studies will be essential to accurately determine the solubility limits and enhance its practical applications.

Interesting facts

Interesting Facts about (1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one

This compound, often referred to by its systematic name, is a fascinating entity in the realm of organic chemistry due to its complex structure and potential applications. Here are some engaging aspects that might pique your interest:

  • Unique Structural Features: The compound's pentacyclic structure, which consists of multiple interconnected rings, makes it particularly interesting for studies in stereochemistry and molecular interactions.
  • Fluorine Atom: The presence of a fluorine atom significantly influences its chemical reactivity and biological activity, as fluorinated compounds often exhibit enhanced properties over their non-fluorinated counterparts.
  • Hydroxyl Group: The hydroxyl (-OH) group adds a layer of polarity and can enhance hydrogen bonding capabilities, which can be crucial in biological systems and synthetic applications.
  • Potential Biological Activity: Such complex molecules often exhibit intriguing biological effects, making them candidates for pharmacological investigation. This compound's structure may hint at potential use in drug discovery, particularly in targeting enzymatic pathways.
  • Applications in Material Science: Beyond biological applications, compounds with unique structural classes can be explored for material sciences, including drug delivery systems and polymer chemistry, due to their functional groups that allow for various modifications.

As a chemical scientist, one cannot overlook the beauty of such intricate structures. The way molecular design can significantly alter the properties of a compound opens a myriad of possibilities, from understanding fundamental chemical principles to advancing real-world applications.

In the world of chemistry, it is often said: "The complexity of a molecule can mirror the complexity of its functions." This sentiment rings true when we study compounds like this one, illustrating the profound connection between molecular architecture and functional prowess.


Synonyms
flurandrenolide
Fludroxycortide
1524-88-5
Fluorandrenolone
Fludroxicortidum
Drenison
Drocort
Sermaka
Flurandrenolone acetonide
Haldrone-F
Alondra-F
Fluorandrenolone acetonide
Fludroxicortida
Fluradrenolide
Fludrossicortide
Fludroxycortidum
CORDRAN SP
Fludroxycortidum [INN-Latin]
Fludroxicortida [INN-Spanish]
Fludroxicortide
Fludroxycortid
HSDB 3084
UNII-8EUL29XUQT
8EUL29XUQT
EINECS 216-196-8
L 33379
DTXSID2047434
Acetonide of 6alpha-fluoro-16alpha-hydroxyhydrocortisone
6alpha-Fluoro-16alpha-hydroxyhydrocortisone 16,17-acetonide
6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione, cyclic 16,17-acetal with acetone
NSC-757869
Flurandrenolide [USAN:USP]
6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxyprogesterone cyclic 16,17-acetal with acetone
Pregn-4-ene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-
Pregn-4-ene-3,20-dione, 6alpha-fluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
DTXCID0027434
Fluoroandrenolone acetonide
NSC 757869
Pregn-4-ene-3,20-dione, 6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
CORDRAN-N COMPONENT FLURANDRENOLIDE
Flurandrenolide (USAN:USP)
Fludroxycortidum (INN-Latin)
Fludroxicortida (INN-Spanish)
FLUDROXYCORTIDE (MART.)
FLUDROXYCORTIDE [MART.]
FLURANDRENOLIDE (USP-RS)
FLURANDRENOLIDE [USP-RS]
FLURANDRENOLIDE (USP MONOGRAPH)
FLURANDRENOLIDE [USP MONOGRAPH]
D07AC07
FLURANDRENOLIDE COMPONENT OF CORDRAN-N
216-196-8
33379
Flurandrenolone
Cordran
Haelan
Fludrossicortide [DCIT]
Fludroxycortide [INN]
MLS000069556
MLS001148136
SMR000058825
Floudroxycortide
Flurandrenolide 100 microg/mL in Acetonitrile
Flurandrenolide [USAN]
(1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-17-en-16-one
(1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one
(2S,6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-2-fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one
Flurandrenolide (USP)
CORDRAN (TN)
Fludroxycortide;Flurandrenolone
Fludroxycortide (JAN/INN)
NCGC00016586-01
CAS-1524-88-5
Prestwick_1065
Opera_ID_1618
Prestwick0_000645
Prestwick1_000645
Prestwick2_000645
Prestwick3_000645
Flurandrenolide (Standard)
SCHEMBL4694
FLURANDRENOLIDE [MI]
BSPBio_000649
FLUDROXYCORTIDE [JAN]
FLURANDRENOLIDE [HSDB]
SPBio_002570
FLURANDRENOLIDE [VANDF]
BPBio1_000715
CHEBI:5127
GTPL7606
CHEMBL1201012
FLUDROXYCORTIDE [WHO-DD]
HY-B1013R
HMS1570A11
HMS2097A11
HMS2233C04
HMS3714A11
HY-B1013
PREGN-4-ENE-3,20-DIONE, 6-FLUORO-11,21-DIHYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-, (6.ALPHA.,11.BETA.,16.ALPHA.)-
Tox21_110509
Tox21_302611
FLURANDRENOLIDE [ORANGE BOOK]
Tox21_110509_1
CCG-220645
CS-4526
DB00846
FF23506
NCGC00023234-03
NCGC00023234-05
NCGC00256709-01
DA-53261
MS-27824
NS00010341
D00328
F85212
EN300-19631165
SR-01000003119
Q5462632
SR-01000003119-3
BRD-K00824317-001-03-0
(4R,8S,9S,11S,13R,19S)-19-Fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one
(6?,11?,16?)-6-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione;6?-Fluoro-11?,21-dihydroxy-16?,17?- (isopropylidenedioxy)pregn-4-ene-3,20-dione;6?-Fluoro-16?-hydroxyhydrocortisone 16,17-acetonide