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Vincristine

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Identification
Molecular formula
C46H56N4O10
CAS number
57-22-7
IUPAC name
[(1S,4R,5R,7S,8R)-8-acetoxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate
State
State

At room temperature, Vincristine is in a solid state. It is typically available as a powder that is reconstituted into a solution for intravenous use in chemotherapy.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
824.99g/mol
Molar mass
825.9980g/mol
Density
1.4600g/cm3
Appearence

Vincristine is a white to off-white powder. It is soluble in water and sparingly soluble in ethanol and ether, which makes it suitable for use in aqueous solutions. It must be handled under specific conditions to ensure stability and is generally packaged in vials for medical use.

Comment on solubility

Solubility of the Compound

The compound [(1S,4R,5R,7S,8R)-8-acetoxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate presents a complex solubility profile, largely influenced by its extensive functional groups and structural characteristics. Understanding its solubility is critical for its potential application in various fields.

Key Factors Affecting Solubility:

  • Polarity: The presence of multiple hydroxyl (–OH) groups significantly enhances the compound's ability to interact with polar solvents such as water.
  • Functional Groups: Acetoxy and methoxy groups may contribute to the solubility in organic solvents, while the benzoate moiety may offer limited solubility in non-polar environments.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to hydroxyl groups aids in solubilizing the compound in polar media.

Ultimately, it is likely that this compound exhibits:

  1. Good solubility in polar solvents like water and alcohols due to its hydroxyl groups.
  2. Limited solubility in non-polar solvents, which may restrict its use in certain formulations.
  3. Variable solubility depending on the pH of the solution and the presence of other solutes.

In summary, the solubility of this compound is influenced by its complex molecular structure and the interplay of its various functional groups, making it essential to consider solvent choice when working with this substance.

Interesting facts

Interesting Facts about Benzoate Compound

This compound, which belongs to a complex class of organic molecules, showcases both remarkable structural diversity and significant potential within the field of medicinal chemistry. Here are some captivating insights:

  • Natural Products: Many compounds in this category are derived from natural sources, especially plants and fungi. This one might possess unique properties due to its complex structure and functional groups.
  • Potential Pharmacological Properties: Compounds with similar structures have been studied for various biological activities, including anti-inflammatory, anti-cancer, and antimicrobial effects. Investigating this compound could lead to the discovery of new therapeutic agents.
  • Complex Stereochemistry: The stereocenters indicated by the (1S,4R,5R,7S,8R) nomenclature illustrate the compound's chiral nature, which plays a pivotal role in determining its biological activity. The spatial arrangement of the atoms can significantly influence its interactions in biological systems.
  • Supramolecular Chemistry: This compound's intricate arrangements may allow for fascinating studies in supramolecular chemistry, as it may participate in various non-covalent interactions that facilitate assembly or recognition processes.
  • Research Opportunities: Ongoing research involves exploring derivatives of such complex compounds to improve efficacy and reduce potential side effects. Investigating variations of this compound can lead to promising new drugs.

In summary, this compound exemplifies the significance of structural complexity in medicinal chemistry, revealing a world rich with potential for scientific exploration. As we advance our understanding of such compounds, we unlock new pathways for therapeutic interventions and innovative applications in healthcare.