Mirtazapine | Solubility of Things

Identification

Molecular formula

C₁₇H₁₉N₃O

CAS number

61337-67-5

IUPAC name

(1S,9R,10S)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol

State

At room temperature, Mirtazapine is a solid. It is used as an antidepressant and is commonly formulated into tablets for medical use.

Melting point (Celsius)

114.00

Melting point (Kelvin)

387.15

Boiling point (Celsius)

446.60

Boiling point (Kelvin)

719.80

General information

Molecular weight

265.36g/mol

Molar mass

265.3660g/mol

Density

1.3000g/cm³

Appearence

Mirtazapine typically appears as a white to off-white crystalline powder. It is practically insoluble in water, and freely soluble in methanol. This appearance is common in its pure form and used in laboratories and pharmaceutical formulations.

Comment on solubility

Solubility Overview

The compound (1S,9R,10S)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol presents a unique profile when it comes to solubility. Its complex molecular structure significantly influences its interaction with solvents. Here are some important points to consider:

Polar vs. Non-Polar Solvents: This compound is likely to have variable solubility in polar solvents such as water and methanol due to the presence of hydroxyl (-OH) functional groups, which can engage in hydrogen bonding.
Hydrophobic Regions: The tetracyclic structure suggests that there are hydrophobic regions that may hinder solubility in highly polar environments.
Solubility Variations: It may exhibit different solubility profiles depending on temperature and solvent composition, possibly being more soluble in organic solvents like ethanol or ethyl acetate.

Overall, the solubility of (1S,9R,10S)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol can be better understood through careful experimentation and consideration of its specific structural attributes. This compound exemplifies the idea that "the structure governs solubility," highlighting the intricate balance between hydrophilic and hydrophobic characteristics in chemical behavior.

Interesting facts

Interesting Facts about (1S,9R,10S)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol

This compound, a complex organic molecule, belongs to a class of compounds known for their unique structural characteristics and biological activities. Here are some fascinating insights into its properties and significance:

Structural Complexity: The name reflects a highly intricate structure with multiple rings and functional groups. The presence of azole suggests it may be involved in important biological processes.
Biological Relevance: Compounds of this nature often mimic or inhibit biological molecules, making them candidates for pharmaceutical applications. This specific compound could potentially interact with biological pathways.
Chiral Centers: The compound contains specific stereocenters (1S, 9R, and 10S), indicating that it exists in different forms (enantiomers). This chirality can significantly affect its biological activity and how it interacts with biological systems.
Potential Uses: Research into structurally complex molecules has led to discoveries in treatments for diseases, such as cancer or bacterial infections. This compound might hold promise in medicinal chemistry.
Historical Insight: Such compounds often have rich histories in the development of natural products and have served as inspiration in organic synthesis and drug discovery.

As quoted by a leading chemist, “The beauty of chemistry lies not only in the elements but in the structures we create and their profound impacts on life.” This compound stands as a testament to that beauty and possibility.

In conclusion, the explorations of (1S,9R,10S)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol encompass a landscape filled with potential, inviting researchers to unlock its secrets and applications.