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Cilomilast

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Identification
Molecular formula
C25H23ClN2O3S
CAS number
153259-65-5
IUPAC name
2-[1-[[1-[3-[2-(7-chloro-2-quinolyl)vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
State
State

Cilomilast is usually found in a solid state at room temperature, characteristic of many small-molecule pharmaceuticals.

Melting point (Celsius)
144.00
Melting point (Kelvin)
417.15
Boiling point (Celsius)
460.30
Boiling point (Kelvin)
733.45
General information
Molecular weight
444.98g/mol
Molar mass
444.9530g/mol
Density
1.2500g/cm3
Appearence

Cilomilast typically appears as a white to off-white crystalline powder. Handling it usually requires precautions to maintain its stability and effectiveness.

Comment on solubility

Solubility of 2-[1-[[1-[3-[2-(7-chloro-2-quinolyl)vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid

The solubility of the compound with the chemical formula C25H23ClN2O3S is indeed remarkable given its complex structure. Here’s what we can deduce about its solubility characteristics:

  • Nature of Solvent: The solubility can vary significantly depending on whether it is tested in polar solvents (like water) or non-polar solvents (such as organic solvents).
  • Environmental Factors: Factors such as temperature and pH can greatly influence the solubility of this compound.
  • Functional Groups: The presence of functional groups like the carboxylic acid (–COOH) may improve solubility in polar solvents due to hydrogen bonding.
  • Chlorine Substituent: The chlorine atom may affect both lipophilicity and solubility in non-polar environments.
  • Complex Molecular Structure: Given its large and intricate molecular architecture, the solubility might be limited in many common solvents, showcasing a unique chemical behavior.

In summary, while the solubility of 2-[1-[[1-[3-[2-(7-chloro-2-quinolyl)vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid is influenced by its functional groups and overall structure, experimental determination remains essential for precise solubility data. Always remember, “The more complex the molecule, the more complex the solubility.”

Interesting facts

Interesting Facts about 2-[1-[[1-[3-[2-(7-chloro-2-quinolyl)vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid

This compound is an intriguing example of a complex organic molecule, featuring a rich tapestry of functional groups and structural motifs. Its unique structure allows for a wide range of potential applications in various fields. Here are some fascinating insights:

  • Diverse Structure: The molecule's intricate design includes a cyclopropyl ring and multiple aromatic systems, presenting significant opportunities for research.
  • Biological Activity: Compounds with similar structures are often investigated for their biological effects, especially in pharmacology. Preliminary studies have suggested potential anti-cancer activity, possibly due to targeting specific cellular pathways.
  • Chlorine Substitution: The presence of a chlorine atom enhances the lipophilicity of the compound, which can impact its biological interactions and pharmacokinetics.
  • Sulfanylmethyl Group: The sulfanylmethyl moiety can impart unique properties, making it interesting for synthesis as well as functionalization in medicinal chemistry.

As stated by leading researchers in the field, “The exploration of complex organic molecules can lead to groundbreaking discoveries in medicinal chemistry.” The ongoing study of compounds like this one underscores the importance of interdisciplinary collaboration among chemists, biologists, and pharmacologists.

In summary, 2-[1-[[1-[3-[2-(7-chloro-2-quinolyl)vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid represents a fascinating intersection of synthesis, activity, and potential therapeutic application, making it a compelling subject for further research.

Synonyms
cis-Montelukast
2-[1-[[1-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
rac-Montelukast acid
MK0476 (free acid)
MFCD05662278
Montelukast EP impurity G
SCHEMBL130083
DTXSID50861406
BCP03767
BCP28542
TTB74629
VIA92727
SB19081
(1-{[(1-{3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl)sulfanyl]methyl}cyclopropyl)acetic acid
SY269703
DB-064253
MK 0476;MK-0476;MK0476
Q27166194
(R,E)-2-[1-[[[1-[3-[2-(7-Chloro-2-quinolyl)vinyl]phenyl]-3-[2-(2-hydroxy-2-propyl)phenyl]propyl]thio]methyl]cyclopropyl]acetic Acid
2-(1-(((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)thio)methyl)cyclopropyl)acetic acid
2-[1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]thio]methyl]cyclopropyl]acetic acid