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Lisinopril

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Identification
Molecular formula
C21H31N3O5
CAS number
83915-83-7
IUPAC name
2-[[1-(2-amino-3-methyl-pentanoyl)pyrrolidine-2-carbonyl]amino]-3-methyl-pentanoic acid
State
State

Lisinopril is typically found in a solid state at room temperature. This compound is stable under normal conditions.

Melting point (Celsius)
162.00
Melting point (Kelvin)
435.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
405.50g/mol
Molar mass
405.4930g/mol
Density
1.2340g/cm3
Appearence

Lisinopril appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-[[1-(2-amino-3-methyl-pentanoyl)pyrrolidine-2-carbonyl]amino]-3-methyl-pentanoic Acid

The solubility of the compound 2-[[1-(2-amino-3-methyl-pentanoyl)pyrrolidine-2-carbonyl]amino]-3-methyl-pentanoic acid, with the molecular formula C21H31N3O5, can be influenced by several factors. Understanding these factors is critical for applications in pharmaceuticals and biochemistry where solubility plays a vital role.

Factors Affecting Solubility

  • Polarity: The presence of polar functional groups can significantly enhance solubility in polar solvents, such as water.
  • Hydrogen Bonding: The amino functional groups in the compound may facilitate hydrogen bonding, increasing solubility.
  • pH Levels: Solubility may vary with pH, especially for compounds containing acidic or basic groups.
  • Temperature: Higher temperatures often increase solubility in many compounds, although this can vary.

Typically, compounds like this amino acid derivative, which also contain hydrophobic carbon chains, may exhibit limited solubility in aqueous solutions but could be more soluble in organic solvents. Careful consideration of these solubility dynamics is essential when formulating drugs or designing experiments involving this compound.

In summary, while the exact solubility of this compound is not widely documented, factors such as polarity, hydrogen bonding, pH, and temperature will play significant roles in determining its behavior in different environments. Always consult experimental data for precise solubility information.

Interesting facts

Interesting Facts about 2-[[1-(2-amino-3-methyl-pentanoyl)pyrrolidine-2-carbonyl]amino]-3-methyl-pentanoic acid

This compound is a fascinating example of a complex natural occurring amino acid derivative that showcases the intricate relationship between structure and function in biochemistry. Here are some intriguing aspects to consider:

  • Biological Significance: This compound may be involved in various biochemical pathways, potentially influencing protein synthesis and metabolism due to its amino acid functionalities.
  • Structural Complexity: The presence of a pyrrolidine ring adds a layer of complexity to this compound's structure, which can have significant implications on its biological activities, including its ability to interact with various enzymes and receptors.
  • Synthetic Pathways: The synthesis of such complex compounds often involves multiple steps and conditions, making it an exciting challenge for chemists. The knowledge gained in the process can lead to the development of new synthetic methodologies.
  • Potential Therapeutic Applications: Compounds with similar structures are often explored for their potential therapeutic effects, such as anti-cancer properties or as neurotransmitter modulators, showcasing how alterations in structure can lead to vastly different activities.
  • Research Opportunities: The exploration of this compound opens up research avenues in medicinal chemistry, structural biology, and pharmacology, leading to discoveries that could enhance our understanding of biological systems.

As a chemistry student or scientist, diving into the intricacies of such compounds offers an invaluable perspective on the delicate balance between chemical structure and biological function. By studying these compounds, one can appreciate the sophisticated designs found in nature and how they can inspire innovative solutions in drug discovery and development.

Synonyms
MLS002207185
NSC602337
HIV inhibitor
H-Ile-Pro-Ile-OH
DivK1c_000899
CHEMBL158110
SCHEMBL17867000
HMS502M21
KBio1_000899
NINDS_000899
IDP-4132-V
Ile-Pro-Ile, >=97% (HPLC)
BDBM50085083
NSC-602337
IDI1_000899
SMR001306756
DB-057213
Bacillus cereus BMF673-RF1 culture filtrate
2-{[1-(2-Amino-3-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoic acid