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Cefotaxime

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Identification
Molecular formula
C16H17N5O7S2
CAS number
64485-93-4
IUPAC name
2-[[1-(2-aminothiazol-4-yl)-2-[[2-(carbamoyloxymethyl)-4-oxo-1-sulfo-azetidin-3-yl]amino]-2-oxo-ethylidene]amino]oxyacetic acid
State
State

At room temperature, cefotaxime exists as a solid. It is commonly utilized in clinical settings in its reconstituted form, where it is dissolved into a liquid for intravenous or intramuscular injection.

Melting point (Celsius)
167.00
Melting point (Kelvin)
440.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
455.45g/mol
Molar mass
455.4540g/mol
Density
1.5400g/cm3
Appearence

Cefotaxime typically appears as a white to off-white crystalline powder. It is often provided as a sodium salt for injection, where it dissolves to form a colorless to pale yellow solution. The hue of the solution can vary slightly depending on concentration and conditions of dissolution.

Comment on solubility

Solubility of 2-[[1-(2-aminothiazol-4-yl)-2-[[2-(carbamoyloxymethyl)-4-oxo-1-sulfo-azetidin-3-yl]amino]-2-oxo-ethylidene]amino]oxyacetic acid

The solubility of a compound is a crucial property that influences its behavior in various environments. For the compound with the chemical formula C16H17N5O7S2, there are several important considerations regarding its solubility:

  • Polar Characteristics: The presence of multiple functional groups such as amino (-NH2), sulfonyl (-SO3), and carboxylic acid (-COOH) indicates that this compound is likely polar and should exhibit reasonable solubility in polar solvents, particularly water.
  • pH Dependency: Being an acid, its solubility may also depend on the pH of the solution; it is likely to be more soluble at lower pH values due to protonation of the amino groups, which can enhance solvation.
  • Hydrogen Bonding: The potential for hydrogen bonding between the compound and solvent molecules can further increase solubility, making this compound more compatible with aqueous environments.
  • Comparative Solubility: When compared to similar compounds, those with a balance of hydrophobic and hydrophilic portions typically display interesting solubility profiles in mixed solvent systems.

In summary, the compound C16H17N5O7S2 is likely to be soluble in polar solvents like water due to its chemical structure, but specific experimental data would provide definitive insights into its solubility characteristics.

Interesting facts

Interesting Facts about 2-[[1-(2-aminothiazol-4-yl)-2-[[2-(carbamoyloxymethyl)-4-oxo-1-sulfo-azetidin-3-yl]amino]-2-oxo-ethylidene]amino]oxyacetic acid

This intriguing compound, known for its complexity and structural uniqueness, has captured the attention of researchers in medicinal chemistry due to its potential therapeutic applications. Here are some fascinating aspects:

  • Structural Diversity: The compound features multiple functional groups, such as thiazole, sulfonyl, and carbamoyl, which contribute to its diverse chemical behavior and possible reactivity.
  • Biological Significance: Compounds like this one are often explored for their antibacterial and antifungal properties, making them valuable in the development of new treatments against resistant pathogens.
  • Design Goals: The design of such a compound typically targets a specific biological mechanism, aiming to disrupt microbial activity or enhance host defense mechanisms. Its structure suggests potential use in drug discovery.
  • Research Applications: Beyond its medicinal uses, it also serves as a scaffold for synthesizing library compounds, facilitating the development of derivatives with tailored efficacy.
  • Regulatory Considerations: Given the presence of sulfonic acid, researchers must also consider the solubility and bioavailability aspects when investigating its pharmacokinetics and pharmacodynamics.

In conclusion, the compound stands as a unique bridge between synthetic organic chemistry and pharmacological research, underscoring the importance of multi-functionalized compounds in exploring innovative solutions to pharmaceutical challenges. As noted by many in the field, "The future of drug discovery lies in the precise manipulation of such complex molecules."

Synonyms
Carumonam
87638-04-8
DTXSID40861091
({[1-(2-amino-1,3-thiazol-4-yl)-2-({2-[(carbamoyloxy)methyl]-4-oxo-1-sulfoazetidin-3-yl}amino)-2-oxoethylidene]amino}oxy)acetic acid
DB-057012