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Rac-loratadine

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Identification
Molecular formula
C22H23ClN2O
CAS number
79794-75-5
IUPAC name
2-[1-(2-isopropylphenyl)-2-methyl-cyclohexoxy]-N,N-dimethyl-ethanamine
State
State

Rac-loratadine exists as a solid at room temperature. It is often found in the form of tablets or pills in pharmaceutical applications. In its pure form, it maintains its solid-state properties under standard conditions of temperature and pressure.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
509.09
Boiling point (Kelvin)
782.24
General information
Molecular weight
382.88g/mol
Molar mass
382.5360g/mol
Density
1.0089g/cm3
Appearence

In its pure form, rac-loratadine is typically a crystalline solid. It appears as a white to off-white powder, which is characteristic of many pharmaceutical compounds. The crystalline nature of the material is due to the structured arrangement of its molecules in the solid state. This compound is often processed into tablets or liquid formulations for pharmaceutical use.

Comment on solubility

Solubility of 2-[1-(2-isopropylphenyl)-2-methyl-cyclohexoxy]-N,N-dimethyl-ethanamine

The solubility of the compound 2-[1-(2-isopropylphenyl)-2-methyl-cyclohexoxy]-N,N-dimethyl-ethanamine can be rather complex due to its unique structure. Here are a few key points to consider:

  • Solvent Interaction: This compound features large hydrophobic groups, suggesting that it may have low solubility in polar solvents like water.
  • Non-Polar Solvents: Solubility may be higher in non-polar solvents such as hexane or toluene due to favorable interactions with similar non-polar environments.
  • Temperature Dependency: As with many organic compounds, solubility could increase with higher temperatures, which enables better miscibility in non-polar substances.
  • Functional Groups: The presence of the amine group may allow the compound to engage in hydrogen bonding to a limited extent, possibly enhancing solubility in certain organic solvents.

In summary, while this compound might exhibit limited solubility in polar solvents, it is likely to be more compatible with non-polar organic solvents. Experimental solubility tests would provide more clarity regarding its behavior in various environments. Remember, understanding solubility is key in predicting how a compound will behave in different situations, especially in chemical reactions and formulations.

Interesting facts

Interesting Facts about 2-[1-(2-isopropylphenyl)-2-methyl-cyclohexoxy]-N,N-dimethyl-ethanamine

This compound belongs to a class of organic molecules often utilized in medicinal chemistry, primarily as a building block for various pharmaceuticals. Known for its unique structure, it features both aromatic and alicyclic components, contributing to its potential biological activity. Here are some key points of interest:

  • Diverse Applications: Compounds of this nature are often explored for their therapeutic properties, potentially acting as antihistamines, antidepressants, or other medicinal agents.
  • Synthetic Versatility: The presence of different functional groups in its structure provides a rich platform for further chemical manipulation and modification, enabling the synthesis of analogs with varied biological activities.
  • Structure-Activity Relationship (SAR): Studying this compound allows scientists to unveil the relationships between its structure and the resulting biological effects, paving the way to design more effective drugs.
  • Chirality and Pharmacodynamics: If this compound contains chiral centers, its stereoisomers might exhibit distinct pharmacological profiles, underscoring the importance of chirality in drug design.
  • Research Frontiers: Ongoing research into similar compounds continues to reveal new mechanisms of action, which could lead to innovative treatments with fewer side effects.

As the scientific community advances its understanding of such compounds, they serve not only as essential building blocks in drug development but also as fascinating subjects for study, revealing insights into molecular interactions and pharmacology. In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This underscores the beauty of chemical research, where each compound offers a window into endless possibilities.