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Oxymetazoline Hydrochloride

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Identification
Molecular formula
C16H25Cl3N2O
CAS number
2315-02-8
IUPAC name
2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole;hydrochloride
State
State

At room temperature, oxymetazoline hydrochloride is typically found in a solid state as a crystalline powder.

Melting point (Celsius)
261.00
Melting point (Kelvin)
534.15
Boiling point (Celsius)
362.20
Boiling point (Kelvin)
635.35
General information
Molecular weight
296.21g/mol
Molar mass
296.2060g/mol
Density
1.2500g/cm3
Appearence

Oxymetazoline hydrochloride appears as a white to off-white powder. It is crystalline in nature and is known for its slightly bitter taste. The compound is often found in the form of a nasal spray or solution for medical use.

Comment on solubility

Solubility of 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole; hydrochloride

The solubility of 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole; hydrochloride can be attributed to its ionic nature as a hydrochloride salt. This characteristic typically enhances the compound's solubility in polar solvents, particularly water. Here are some important points regarding its solubility:

  • Hydrochloride Form: Being in hydrochloride form usually increases the solubility in aqueous solutions due to the ionization of the compound.
  • Polarity: The presence of the -Cl substituents and polar groups may contribute to increased interactions with solvent molecules.
  • Temperature Dependence: Its solubility may vary with temperature, often increasing at higher temperatures.
  • pH Influence: The solubility can further be influenced by the pH of the solution, wherein highly acidic or basic conditions might aid in solubilization.

In conclusion, while specific quantitative solubility data may not be readily available, it can be suggested that due to its hydrochloride nature and the influence of its functional groups, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole; hydrochloride is likely to demonstrate good solubility in water and other polar solvents. This solubility profile is essential for its functional applications in various fields.

Interesting facts

Interesting Facts about 2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole; Hydrochloride

This compound is a fascinating example of modern medicinal chemistry, particularly notable for its role in pharmaceutical research. Here are some interesting insights into its characteristics and applications:

  • Biological Activity: The compound exhibits a range of biological activities, especially in the fields of pharmacology and biochemistry. Its structure allows it to interact meaningfully with biological targets, leading to the exploration of its potential as a therapeutic agent.
  • Mechanism of Action: While the precise mechanisms of action can vary, compounds like this often act by modulating receptor activity or inhibiting enzyme function. This makes them critical in therapeutic contexts where specific pathways must be targeted.
  • Synthetic Routes: The synthesis of this compound involves specific techniques that highlight the ingenuity of chemical synthesis. Chemists utilize strategic reactions to build the complex structure, making it a subject of study in organic synthesis courses.

As a scientist or student, understanding the implications of 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole; hydrochloride can enhance your comprehension of drug development processes. This compound not only serves as a lead compound for further modification but could also provide insight into the design of new pharmaceuticals.

In summary, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole; hydrochloride encapsulates the intersection of structural design and biological relevance, making it an intriguing target for ongoing research in the field of medicinal chemistry.

Synonyms
Lofexidine hydrochloride
21498-08-8
LOFEXIDINE HCl
MDL 14,042
V47G1SDI1B
MDL-14042
NSC-759654
2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole hydrochloride
DTXSID0020781
2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole hydrochloride
1H-Imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-, monohydrochloride
2-(1-(2,6-Dichlorophenoxy)ethyl)-2-imidazoline monohydrochloride
lofexidine monohydrochloride
2-[1-(2,6-Dichlorophenoxy)ethyl]-2-imidazoline monohydrochloride
RefChem:58520
Lofexidine mono-hydrochloride
DTXCID60781
809-032-7
Lofetensin
Lofexidine.HCl
Lofexidine (hydrochloride)
Britlofex
Lofexidine hydrochloride [USAN]
MFCD00917022
2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole;hydrochloride
Lucemyra
1H-Imidazole, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-,monohydrochloride
Loxacor
Lofexidine hydrochloride (USAN)
Loxacor hydrochloride
Lofetensin hydrochloride
Lofexidine HCl
Lofexidine (TN)
RMI-14042A
Lucemyra (TN)
BA 168
UNII-V47G1SDI1B
MLS001424245
SCHEMBL124601
CHEMBL1788132
DWWHMKBNNNZGHF-UHFFFAOYSA-N
2-(1-(2,6-Dichlorophenoxy)ethyl)-2-imidazoline hydrochloride
GLXC-22321
Pharmakon1600-01502357
BCP30600
HY-B1052
Lofexidine HCl - Bio-X trade mark
2-(1-(2,6-Dichlorphenoxy)aethyl)-2-imidazolin-hydrochlorid [German]
LOFEXIDINE HYDROCHLORIDE [MI]
NSC759654
ZB0287
2-{1-[(2,6-dichlorophenyl)oxy]ethyl}-4,5-dihydro-1H-imidazole hydrochloride
2-IMIDAZOLINE, 2-(1-(2,6-DICHLOROPHENOXY)ETHYL)-, MONOHYDROCHLORIDE
AKOS015902903
CCG-101139
CCG-213049
CS-4574
FL24920
FL65064
NC00389
NSC 759654
(-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene hydrochloride
LOFEXIDINE HYDROCHLORIDE [MART.]
LOFEXIDINE HYDROCHLORIDE [VANDF]
LOFEXIDINE HYDROCHLORIDE [WHO-DD]
AS-31095
SMR000469232
SW197769-3
LOFEXIDINE HYDROCHLORIDE [ORANGE BOOK]
D04765
498L088
Q27291521
2-(1-(2,6-Dichlorphenoxy)aethyl)-2-imidazolin-hydrochlorid
2-[1-(2,6-dichlorophenoxy) -ethyl]2-imidazoline hydrochloride
2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazolehydrochloride
Lofexidine HCl;Lofexidine monohydrochloride;Baq-168; MDL-14042;BA 168;MDL 14,042