Skip to main content

Indomethacin

ADVERTISEMENT
Identification
Molecular formula
C19H16ClNO4
CAS number
53-86-1
IUPAC name
2-[1-(4-chlorobenzoyl)-2-methyl-indolizin-3-yl]acetic acid
State
State

At room temperature, indomethacin is typically in a solid state.

Melting point (Celsius)
160.00
Melting point (Kelvin)
433.15
Boiling point (Celsius)
540.00
Boiling point (Kelvin)
813.15
General information
Molecular weight
357.79g/mol
Molar mass
357.7890g/mol
Density
1.4000g/cm3
Appearence

Indomethacin appears as a white to yellow crystalline powder. It is practically insoluble in water, slightly soluble in alcohol, and soluble in dimethylformamide and acetone.

Comment on solubility

Solubility of 2-[1-(4-chlorobenzoyl)-2-methyl-indolizin-3-yl]acetic acid

The solubility of 2-[1-(4-chlorobenzoyl)-2-methyl-indolizin-3-yl]acetic acid can be described through several key features:

  • Polar character: The presence of the acetic acid functional group contributes to its polar nature, potentially increasing solubility in polar solvents such as water.
  • Hydrophobic interactions: The 4-chlorobenzoyl moiety and the indolizin ring contribute to hydrophobic characteristics, which may hinder solubility in highly polar environments.
  • Temperature dependency: Like many organic compounds, solubility may improve with increasing temperature, thus affecting its practicality in different conditions.
  • pH sensitivity: Being an acid, solubility might also vary considerably with changes in pH, affecting its ionization state and consequently influencing how well it dissolves in aqueous solutions.

Overall, while 2-[1-(4-chlorobenzoyl)-2-methyl-indolizin-3-yl]acetic acid exhibits characteristics that could lead to solubility in various solvents, it is essential to consider the balance between its polar and non-polar components in determining its overall solubility profile. Understanding these interactions can aid in predicting the behavior of this compound in different environments.

Interesting facts

Interesting Facts about 2-[1-(4-chlorobenzoyl)-2-methyl-indolizin-3-yl]acetic Acid

This fascinating compound is well-known for its potential applications in medicinal chemistry and synthetic biology. Here are some intriguing aspects about it:

  • Structural Complexity: The molecule features a unique indolizin backbone, which is characterized by its nitrogen-containing heterocyclic structure. This complexity contributes to its diverse biological properties.
  • Biological Activity: Due to the presence of the 4-chlorobenzoyl moiety, this compound could be involved in several pharmacological activities, making it a candidate for drug development.
  • Synthetic Pathways: Researchers are fascinated by the synthetic routes leading to the formation of this compound, often employing multistep synthetic processes that highlight creativity and ingenuity in the laboratory.
  • Research Insights: Its role in various studies may significantly enhance our understanding of receptor interactions, enabling scientists to manipulate biological pathways for therapeutic purposes.
  • Environmental Perspectives: As a chlorinated compound, it is essential to explore its environmental impact and behavior, ensuring safe usage in any applications.

In summary, 2-[1-(4-chlorobenzoyl)-2-methyl-indolizin-3-yl]acetic acid is more than just a chemical entity; it represents a blend of structural elegance and potential utility in the realm of chemical and biological research. As scientists continue to explore its capabilities, there is much hope that this compound could lead to new advancements in medicine and beyond.

Synonyms
BRN 0493569
3-INDOLIZINEACETIC ACID, 1-(p-CHLOROBENZOYL)-2-METHYL-
1-(p-Chlorobenzoyl)-2-methyl-3-indolizineacetic acid
DTXSID40181064
5-22-06-00476 (Beilstein Handbook Reference)
RefChem:279999
DTXCID50103555
26466-68-2