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Indometacin

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Identification
Molecular formula
C19H16ClNO4
CAS number
53-86-1
IUPAC name
2-[1-(4-chlorobenzoyl)-5-formyl-2-methyl-indol-3-yl]acetic acid
State
State

At room temperature, Indometacin is typically in a solid crystalline form.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
357.79g/mol
Molar mass
357.7890g/mol
Density
1.4000g/cm3
Appearence

Indometacin is a white to yellow crystalline powder.

Comment on solubility

Solubility of 2-[1-(4-chlorobenzoyl)-5-formyl-2-methyl-indol-3-yl]acetic acid

The solubility of 2-[1-(4-chlorobenzoyl)-5-formyl-2-methyl-indol-3-yl]acetic acid (C19H16ClNO4) can be characterized by several key factors that influence its behavior in various solvents:

  • Polarity: This compound contains polar functional groups such as the carboxylic acid, which can interact favorably with polar solvents like water.
  • Hydrophobic Regions: The aromatic system and the chloro-substituent contribute to hydrophobic characteristics, suggesting limited solubility in highly polar solvents.
  • Solvent Effects: Solubility will vary significantly between organic solvents (like ethanol or DMSO) and aqueous environments. The presence of chlorine may also impart some specific interactions influencing solubility.

In summary, while 2-[1-(4-chlorobenzoyl)-5-formyl-2-methyl-indol-3-yl]acetic acid may exhibit moderate solubility in polar solvents due to its acidic functional group, the overall solubility is tempered by its complex structure and the presence of hydrophobic elements. It is important to conduct empirical tests to determine the precise solubility profile under varying conditions.

Interesting facts

Exciting Insights into 2-[1-(4-chlorobenzoyl)-5-formyl-2-methyl-indol-3-yl]acetic Acid

This compound represents a fascinating intersection of organic chemistry and pharmaceutical research, showcasing the intricacies of indole derivatives. Here are some notable aspects:

  • Structural Complexity: The structure includes a chlorobenzoyl group and an indole ring. Such complexity often leads to unique chemical properties and potential applications in various fields.
  • Pharmacological Potential: Compounds containing indole structures are known for their varied biological activities, including anti-inflammatory, anticancer, and antimicrobial properties. This compound might exhibit similar promising activities.
  • Research Applications: The presence of an acetic acid functional group enhances the compound's reactivity, making it a valuable candidate in synthetic chemistry, particularly in designing biologically active molecules.
  • Versatile Synthesis: This compound can be synthesized through various methods, which often involve the manipulation of the indole's position and functional groups, showcasing the dynamic nature of organic synthesis.
  • Environmental Considerations: As researchers explore greener synthetic pathways, compounds like this raise questions about sustainability and the environmental impact of chlorinated compounds in pharmaceuticals.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This compound exemplifies the creativity and innovation driving modern chemistry, highlighting how intricate molecular designs can lead to groundbreaking discoveries.

As science continues to unravel the properties and potentials of such compounds, they remain a crucial focus for chemists eager to explore new frontiers in medicine and technology.

Synonyms
Bio1_000912
KBioGR_002384
KBioSS_002389
KBio2_002384
KBio2_004952
KBio2_007520
KBio3_002863
cMAP_000034
Bio1_000423
Bio1_001401