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Diphenhydramine

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Identification
Molecular formula
C17H21NO
CAS number
58-73-1
IUPAC name
2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamine
State
State

Diphenhydramine is generally in a solid state at room temperature. In pharmaceutical formulations, it is often found in the form of tablets or capsules.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
159.00
Boiling point (Kelvin)
432.15
General information
Molecular weight
291.82g/mol
Molar mass
291.8230g/mol
Density
1.0040g/cm3
Appearence

Diphenhydramine is typically found as a white, crystalline powder that is odorless or has a slight characteristic odor. It is commonly available as tablets or capsules when used in medical formulations.

Comment on solubility

Solubility of 2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamine

The solubility characteristics of 2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamine can be intriguing, given its structural complexity and organic composition. Understanding its solubility is essential for applications in various fields, including pharmaceuticals and chemical engineering.

Here are some key points regarding the solubility of this compound:

  • Solvent Compatibility: This compound is generally expected to be soluble in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and acetone due to its hydrophobic aromatic rings.
  • Aqueous Solubility: It is likely to exhibit *limited solubility* in water, a common trait for many organic amines owing to their hydrophobic characteristics.
  • Temperature Effect: An increase in temperature may enhance solubility in organic solvents, as higher temperatures typically favor increased molecular movement and interactions.

Given its unique combination of functional groups, the solubility of this compound should be evaluated empirically. In practical applications, one might consider conducting solubility tests in various solvents to determine optimal conditions for use. For now, it is worth noting that beneficial interactions could arise when the compound is used in co-solvent systems, which could enhance solubility further.

Interesting facts

Interesting Facts about 2-[1-(4-Chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamine

This compound, commonly utilized in the field of medicinal chemistry, boasts an intriguing structure that showcases the diverse possibilities of organic synthesis. Its molecular design indicates the presence of both aromatic and aliphatic components, which often contribute significantly to the compound's pharmacological properties.

Applications in Medicine

2-[1-(4-Chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamine has been studied for its potential as:

  • Antidepressant: Research suggests these types of compounds may exhibit serotonin reuptake inhibition, contributing to mood improvement.
  • Analgesic: The interactions of similar compounds with neural receptors could offer pain relief.
  • Antipsychotic: Its structural components hint at possible effects on dopamine receptors, thus warranting investigation in treating various psychiatric disorders.

Chemical Features

Here are a few noteworthy features:

  • Substituents: The presence of the 4-chlorophenyl group offers a unique platform for interactions with biological systems.
  • Dimethylamino group: This moiety can enhance the lipophilicity of the compound, influencing its ability to cross cell membranes.

Research Opportunities

This compound opens various research avenues, such as:

  • Synthesizing analogs: By modifying the ethyl or phenyl groups, scientists can explore variations in biological activity.
  • Toxicology studies: Understanding the safety profile of such compounds is crucial for their therapeutic application.
  • Mechanistic studies: Investigating how the structure influences its activity can lead to significant discoveries in drug design.

As we delve deeper into the world of chemical compounds, the journey of exploring 2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamine exemplifies how intricate structures can lead to potential advancements in medicinal treatments. One might say, as scientists, we are just beginning to unlock the secrets within these molecular constructs!

Synonyms
Chlorphenoxamine
77-38-3
Contristamine
Clorfenoxamina
Clorfenossamina
Chlorphenoxaminum
2-(1-(4-Chlorophenyl)-1-phenylethoxy)-N,N-dimethylethanamine
Clorfenossamina [DCIT]
Chlorphenoxamine [INN:BAN]
Clorfenoxamina [INN-Spanish]
Chlorphenoxaminum [INN-Latin]
2-[1-(4-Chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine
3UVD77BP8R
BRN 2057618
2-(1-(p-Chlorophenyl)-1-phenylethoxy)-N,N-dimethylethylamine
Chlorphenoxamine (INN)
p-Chlor-alpha-methyl-diphenhydramin
p-Chlor-alpha-methyl-diphenhydramin [German]
CHLORPHENOXAMINE [MI]
CHLORPHENOXAMINE [INN]
{2-[1-(4-Chlorophenyl)-1-phenylethoxy]ethyl}dimethylamine
CHLORPHENOXAMINE [WHO-DD]
EC 616-456-4
4-06-00-04717 (Beilstein Handbook Reference)
beta-Dimethylamino-aethyl-(p-chlor-alpha-methylbenzhydryl)-aether [German]
p-Chlor-.alpha.-methyl-diphenhydramin
2-(1-(4-Chlorophenyl)-1-phenylethoxy)-N,N-dimethylethan-1-amine
beta-Dimethylamino-aethyl-(p-chlor-alpha-methylbenzhydryl)-aether
Ethanamine, 2-(1-(4-chlorophenyl)-1-phenylethoxy)-N,N-dimethyl-
Ethanamine, 2-[1-(4-chlorophenyl)-1-phenylethoxy]-N,N-dimethyl-
ETHYLAMINE, 2-(1-(p-CHLOROPHENYL)-1-PHENYLETHOXY)-N,N-DIMETHYL-
Clorfenoxamina (INN-Spanish)
Chlorphenoxaminum (INN-Latin)
Ethylamine, 2-[1-(p-chlorophenyl)-1-phenylethoxy]-N,N-dimethyl-
ETHENAMINE, 2-(1-(4-CHLOROPHENYL)-1-PHENYLETHOXY)-N,N-DIMETHYL-
2-((P-CHLORO-.ALPHA.-METHYL-.ALPHA.-PHENYLBENZYL)OXY)-N,N-DIMETHYLETHYLAMINE
UNII-3UVD77BP8R
(2-(1-(4-chlorophenyl)-1-phenylethoxy)ethyl)dimethylamine
[1-(p-Chlorophenyl)-1-phenylethyl] (ss-dimethylaminoethyl) ether; 2-[1-(4-Chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine; 2-(p-Chloro-a-methyl-a-phenylbenzyloxy)-N,N-dimethylethylamine; p-Chloro-a-methyldiphenhydramine; ss-Dimethylaminoethyl (p-chloro-a-methylbenzhydryl) ether;
Chlorphenoxamine (Standard)
SCHEMBL29208
CHEMBL2110774
DTXSID5022805
HY-B1607R
D04AA34
R06AA06
CHEBI:135288
BDBM429534
AAA07738
HY-B1607
MFCD00866588
AKOS015894659
CS-5310
DB09007
med.21724, Compound Chlorphenoxamine
NCGC00484055-01
AS-76607
DA-72182
NS00008539
C76477
D07198
SR-01000944418
Q5103225
SR-01000944418-1
2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamine
2-{[1-(4-chlorophenyl)-1-phenylethyl]oxy}-N,N-dimethylethanamine
.beta.-Dimethylamino-aethyl-(p-chlor-.alpha.-methylbenzhydryl)-aether
Ethanamine, 2-(1-(4-chlorophenyl)-1-phenylethoxy)-N,N-dimethyl-(9CI)
2-((P-CHLORO-ALPHA-METHYL-ALPHA-PHENYLBENZYL)OXY)-N,N-DIMETHYLETHYLAMINE
616-456-4