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Diphenhydramine Hydrochloride

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Identification
Molecular formula
C17H22ClNO1
CAS number
147-24-0
IUPAC name
2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamine;hydrochloride
State
State

At room temperature, Diphenhydramine Hydrochloride is in a solid state. It is commonly found in tablet or powder form for medicinal use.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
160.00
Boiling point (Kelvin)
433.15
General information
Molecular weight
291.82g/mol
Molar mass
291.8210g/mol
Density
0.9943g/cm3
Appearence

Diphenhydramine Hydrochloride appears as a white, crystalline powder. It is known for its bitter taste. This compound is soluble in water and alcohol, which makes it suitable for use in various pharmaceutical formulations. Its appearance is typical of many crystalline pharmaceuticals.

Comment on solubility

Solubility of 2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamine; hydrochloride

The solubility of a compound can significantly influence its practical applications, particularly in pharmaceuticals and chemical processing. The compound 2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamine; hydrochloride is noted for its solubility characteristics:

  • Solubility in Water: As a hydrochloride salt, this compound tends to exhibit a high degree of solubility in water. Hydrochlorides generally enhance the solubility of their base compounds due to the ionic nature imparted by the salt formation.
  • Solubility in Organic Solvents: It may also be soluble in various organic solvents, which can facilitate its use in different chemical environments. Solvents such as ethanol or acetone are often employed for dissolving similar compounds.
  • pH Dependency: The solubility could be influenced by the pH of the solution, where changes in pH can affect protonation and, consequently, the solubility profile.

In conclusion, the solubility of this compound aids in its application in various fields, providing an accessible medium for both laboratory research and potential therapeutic usages. To summarize, its solubility can be encapsulated by the following key points:

  1. High solubility in aqueous solutions due to its hydrochloride form.
  2. Possible solubility in organic solvents, broadening its usability in different scenarios.
  3. pH-dependent properties that might be leveraged in specific applications.

Understanding these solubility parameters is crucial for optimizing the compound's performance in different chemical contexts.

Interesting facts

Overview of 2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamine; hydrochloride

This compound is a fascinating member of the family of chemical entities known for their varied applications, particularly in pharmaceutical research. Its complex structure points to a carefully balanced interaction of multiple functional groups, making it an interesting subject for study.

Key Characteristics

  • Structure: The presence of a 4-chlorophenyl group adds a layer of specificity that may affect the binding affinity of this molecule to biological targets, which is critical in drug design.
  • Functional Groups: This compound includes an ethoxy linkage and dimethyl ethylamine, showing potential for significant biological activity and versatility in synthesis.
  • Pharmaceutical Potential: Due to its structural complexity, research is ongoing into its potential roles in various therapeutic areas, including mental health pharmacology and analgesics.

Interesting Insights

One noteworthy aspect of compounds like this is the impact of halogen substituents, such as the chlorine atom in the 4-chlorophenyl portion. These substitutions can alter:

  • **Bioavailability:** The ability of the compound to reach systemic circulation.
  • **Receptor Binding:** How it interacts with specific receptors in the body, which can define its therapeutic efficacy.
  • **Metabolic Stability:** Resistance to enzymatic degradation may enhance its therapeutic window.

As a chemist, the exploration of its properties and interactions could prompt exciting discoveries. The thorough investigation of its synthesis and reactivity profiles can also serve as an excellent teaching opportunity, showcasing the principles of organic chemistry in action, from electronic effects to steric hindrance.

Conclusion

In summary, 2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethyl-ethanamine; hydrochloride stands out as a compound brimming with possibilities. Its finely-tuned structure invites curiosity and further research, promising potential contributions to the fields of medicinal chemistry and pharmacology.

Synonyms
Chlorphenoxamine hydrochloride
562-09-4
Phenoxene
Systral
Clorevan
Contristamine, hydrochloride
EINECS 209-227-1
Substanz NR. 1766 [German]
Substanz NR. 1766
Allergex (TN)
UNII-5I159322PY
Chlorphenoxamine hydrochloride [USP]
5I159322PY
2-(alpha-(p-Chlorophenyl)-alpha-methylbenzyloxy)-N,N-dimethylethylamine
2-((p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethylamine hydrochloride
Ethanamine, 2-(1-(4-chlorophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride
2-((p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine hydrochloride
CHLORPHENOXAMINE HYDROCHLORIDE [MI]
CHLORPHENOXAMINE HYDROCHLORIDE [MART.]
CHLORPHENOXAMINE HYDROCHLORIDE [WHO-DD]
Ethylamine, 2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride
Chlorphenoxamine hydrochloride (USP)
2-((P-CHLORO-.ALPHA.-METHYL-.ALPHA.-PHENYLBENZYL)OXY)-N,N-DIMETHYLETHYLAMINE HYDROCHLORIDE
CHLORPHENOXAMINE HYDROCHLORIDE (MART.)
Allergex
Contristamine Hydrochloride
Ethanamine, 2-(1-(4-chlorophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride (9CI)
209-227-1
Chlorphenoxamine HCl
Chlorphenoxamine (hydrochloride)
2-[1-(4-chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine hydrochloride
Ethenamine, 2-(1-(4-chlorophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride
CHLORPHENOXAMINE HYDROCHLORIDE (200 MG)
Phenoxene hydrochloride
(1-(p-Chlorophenyl)-1-phenyl)ethyl (beta-dimethylaminoethyl) ether hydrochloride
beta-Dimethylaminoethyl (p-chloro-alpha-methylbenzhydryl) ether hydrochloride
SCHEMBL125112
CHEMBL2105980
DTXSID80971587
PAQUKACYLLABHB-UHFFFAOYSA-N
GLXC-20407
NS00080030
D07684
Q27262251
2-[1-(4-chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine;hydrochloride
(1-(P-CHLOROPHENYL)-1-PHENYL)ETHYL (.BETA.-DIMETHYLAMINOETHYL) ETHER HYDROCHLORIDE
2-[1-(4-Chlorophenyl)-1-phenylethoxy]-N,N-dimethylethan-1-amine--hydrogen chloride (1/1)