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5-Methoxy-N,N-dimethyltryptamine

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Identification
Molecular formula
C13H18N2O1
CAS number
61-52-9
IUPAC name
2-(1-benzyl-5-methoxy-indol-3-yl)ethanamine
State
State

At room temperature, 5-Methoxy-N,N-dimethyltryptamine is typically found in a crystalline solid state. When prepared as a salt, such as the fumarate or hydrochloride, it may be a fine powder.

Melting point (Celsius)
69.00
Melting point (Kelvin)
342.15
Boiling point (Celsius)
265.00
Boiling point (Kelvin)
538.15
General information
Molecular weight
218.30g/mol
Molar mass
218.3120g/mol
Density
1.0230g/cm3
Appearence

In its pure form, 5-Methoxy-N,N-dimethyltryptamine appears as a crystalline solid. The color is typically off-white, and it may exhibit a waxy or powdery texture depending on its specific preparation and purity. It is often used in its fumarate or hydrochloride salt form, which are more stable and appear as fine crystalline powders.

Comment on solubility

Solubility of 2-(1-benzyl-5-methoxy-indol-3-yl)ethanamine

The solubility of the compound 2-(1-benzyl-5-methoxy-indol-3-yl)ethanamine is an intriguing aspect, especially when considering its chemical structure and functional groups. Here are some key points to note:

  • Amine Group: The presence of an amine group typically enhances solubility in polar solvents, particularly water, as it can form hydrogen bonds.
  • Hydrophobic Characteristics: The benzyl and methoxy substituents introduce hydrophobic characteristics that can influence overall solubility, potentially limiting its dissolution in aqueous environments.
  • Solvent Dependence: Solubility may vary significantly with different solvents. For instance:
    • High solubility in organic solvents like ethanol and DMSO.
    • Lower solubility in water due to hydrophobic regions.
  • pH Influence: The solubility can also be affected by the pH of the solution. In more acidic environments, the positive charge on the amine may increase solubility.

In conclusion, while 2-(1-benzyl-5-methoxy-indol-3-yl)ethanamine exhibits varying degrees of solubility based on solvent and pH, understanding these characteristics is crucial for applications in pharmaceuticals, where solubility plays a vital role in bioavailability.

Interesting facts

Interesting Facts about 2-(1-benzyl-5-methoxy-indol-3-yl)ethanamine

The compound 2-(1-benzyl-5-methoxy-indol-3-yl)ethanamine, often referred to in studies related to neuropharmacology, provides a captivating insight into the interplay between chemicals and neurological functions. Here are some compelling points to consider:

  • Structure: This compound features an indole moiety, which is a notable framework in many biologically active compounds. Indoles have been studied for their roles in serotonin receptor activity and various therapeutic applications.
  • Biological Activity: Research has indicated that analogs of this compound may exhibit selective serotonin receptor activity. Such interactions can lead to interesting implications in the treatment of mood disorders and anxiety.
  • Natural Inspirations: Many compounds bearing similar structures are derived from natural products, making them pertinent to the field of medicinal chemistry. Nature’s scaffolds play a critical role in drug discovery.
  • Chemical Modifications: The introduction of the methoxy group is particularly intriguing, as it can enhance the lipophilicity of the molecule, potentially affecting its pharmacokinetics and biological availability.
  • Research Potential: Continued exploration into this compound’s interactions could reveal new therapeutic pathways and enhance our understanding of chemical signaling in the brain.

As noted by researchers, "The exploration of such compounds opens doors to novel treatments and enhances our understanding of complex biological systems." This highlights the significance of studying compounds like 2-(1-benzyl-5-methoxy-indol-3-yl)ethanamine in the quest for advanced medical therapies.


In conclusion, the investigation of 2-(1-benzyl-5-methoxy-indol-3-yl)ethanamine is not only an exploration of its chemical and biological properties, but also a fascinating journey into potential therapeutic advancements.

Synonyms
SCHEMBL948319