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Clomipramine

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Identification
Molecular formula
C19H23ClN2O
CAS number
303-49-1
IUPAC name
2-[(1-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)oxy]ethyl-dimethyl-ammonium;4-hydroxy-4-oxo-but-2-enoate
State
State

Clomipramine is typically found in a solid state at room temperature in the form of white crystalline powder.

Melting point (Celsius)
190.50
Melting point (Kelvin)
463.65
Boiling point (Celsius)
431.50
Boiling point (Kelvin)
704.65
General information
Molecular weight
314.84g/mol
Molar mass
314.8370g/mol
Density
1.3000g/cm3
Appearence

Clomipramine appears as a white or slightly off-white crystalline powder. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 2-[(1-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)oxy]ethyl-dimethyl-ammonium;4-hydroxy-4-oxo-but-2-enoate

The solubility of this compound can be quite complex due to its unique structure and the presence of various functional groups. Generally, solubility is dictated by several key factors:

  • Polarity: This compound contains both polar and non-polar characteristics. The presence of the dimethyl-ammonium group contributes to its polar nature, suggesting potential for solubility in polar solvents.
  • Hydrogen Bonding: The hydroxyl group (–OH) can engage in hydrogen bonding, enhancing its solubility in water and other polar solvents.
  • Solvent Interactions: Depending on the solvent used, the compound may exhibit different solubility profiles. For example, it may be more soluble in polar aprotic solvents than in non-polar solvents.

The competition between hydrophobic interactions from the hydrocarbon-like portions and the hydrophilic interactions from the functional groups creates variability in solubility. In practical terms, laboratory assessments would be required to determine quantitative solubility in specific solvents, and it is often stated that:

"The solubility reflects the balance of forces within the compound and its interaction with the solvent."

Overall, while the solubility of this compound may not be readily classified, understanding its structural attributes and the surrounding environment will provide insights into its behavior in solution.

Interesting facts

Interesting Facts about 2-[(1-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)oxy]ethyl-dimethyl-ammonium;4-hydroxy-4-oxo-but-2-enoate

This compound, known for its complex structure and unique properties, presents a fascinating area of study within organic chemistry. Below are some intriguing aspects of this compound:

  • Pharmacological Potential: This compound has garnered attention in medicinal chemistry for its potential applications in drug development, especially in targeting specific biological pathways.
  • Structural Diversity: Featuring a combination of a benzothiepin moiety and a quaternary ammonium group, its intricate structure showcases the versatility of organic molecules in forming diverse chemical architectures.
  • Mechanism of Action: Compounds like this often engage in complex mechanisms within biological systems, making them subjects of extensive research to elucidate how they can influence cellular functions.
  • Research Opportunities: The compound offers opportunities for innovative research, especially in designing derivatives with enhanced efficacy or selectivity toward biological targets.
  • Symmetry and Chirality: The presence of asymmetric centers in the molecule leads to chirality, which can have significant implications in its bioactivity and interactions with biological macromolecules.

The exploration of multifunctional compounds such as this not only enriches our understanding of inorganic chemistry but also paves the way for future advancements in pharmaceutical sciences. As noted by many chemists, "The intersection of organic chemistry and pharmacology is a realm of endless possibilities."


Overall, this compound exemplifies the intricate relationships between molecular structure and biological activity. Its ongoing study highlights the continuing evolution of chemistry as it relates to medicine and environmental science.