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Clopamide

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Identification
Molecular formula
C15H14ClF3N2O4S
CAS number
7280-37-7
IUPAC name
2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]ethyl 4-chloro-3-sulfamoyl-benzoate
State
State

At room temperature, Clopamide is typically in a solid state as a crystalline powder.

Melting point (Celsius)
179.50
Melting point (Kelvin)
452.65
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
396.85g/mol
Molar mass
396.8500g/mol
Density
1.5300g/cm3
Appearence

Clopamide appears as a white to off-white crystalline powder. It is typically odorless and has a bitter taste.

Comment on solubility

Solubility of 2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]ethyl 4-chloro-3-sulfamoyl-benzoate

The solubility of the compound 2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]ethyl 4-chloro-3-sulfamoyl-benzoate is influenced by its complex structure and chemical constituents. Here are some key points regarding its solubility:

  • Polar Functional Groups: The presence of polar groups, such as the sulfonamide and the chloro substituent, generally enhances solubility in polar solvents, particularly water.
  • Hydrophobic Regions: Conversely, the trifluoromethyl group and the hydrophobic phenyl ring can hinder solubility in aqueous environments due to their hydrophobic nature.
  • Solvent Interaction: This compound may demonstrate varying solubility in different solvents; it could be more soluble in organic solvents like ethanol or dimethyl sulfoxide (DMSO) compared to water.
  • Concentration Factors: Concentration levels may also play a critical role, where higher concentrations might lead to increased interactions and thus modifications in solubility characteristics.

In summary, the solubility of this compound is not straightforward and will depend on the balance between its polar and non-polar functional groups. As with many complex molecules, empirical experiments are necessary to accurately determine solubility in specific solvents.

Interesting facts

Interesting Facts about 2-[[1-Methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]ethyl 4-chloro-3-sulfamoyl-benzoate

This compound is a noteworthy member of the sulfonamide class, featuring a complex structure that reflects its potential applications in medicinal chemistry. Here are some intriguing aspects:

  • Pharmacological Potential: Its unique configuration suggests that this compound may possess interesting biological activities, particularly in the field of drug discovery. Sulfonamides, in general, are known for their antibacterial properties, making compounds like this one essential in the ongoing battle against antibiotic resistance.
  • Fluorine Chemistry: The presence of a trifluoromethyl group is particularly intriguing. Compounds with fluorine substitutions often exhibit *enhanced metabolic stability* and *lipophilicity*, which can improve their bioavailability.
  • Structure-Activity Relationship (SAR): The detailed examination of how modifications in the structure affect the biological activity is crucial. This compound's incorporation of a sulfanamide moiety conjugated with a benzoate suggests a careful balance in its design that influences its interaction with biological targets.
  • Applications in Clinical Research: The exploration of this compound could potentially lead to innovations in treatments, particularly in oncology or anti-inflammatory therapies, due to its structural attributes.

In conclusion, the exploration of 2-[[1-Methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]ethyl 4-chloro-3-sulfamoyl-benzoate is a testament to the fascinating advances in chemical synthesis and its implications for healthcare innovation. As researchers delve into its properties, we may well uncover new avenues for therapeutic applications that could significantly impact patient care.

Synonyms
23189-05-1
1204 SE
1204-SE
Benzoic acid, 3-(aminosulfonyl)-4-chloro-, 2-((1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)amino)ethyl ester
RefChem:78302
Benzoic acid, 4-chloro-3-sulfamoyl-, 2-((alpha-methyl-m-(trifluoromethyl)phenethyl)amino)ethyl ester
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl 4-chloro-3-sulfamoylbenzoate
2-[[1-Methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]ethyl=4-chloro-3-sulfamoylbenzoate
BRN 2825638
S 1204
S-1204
2-(alpha-Methyl-m-trifluoromethylphenethylamino)ethanol 4-chloro-3-sulfamoylbenzoate
DTXSID30945854
Ethanol, 2-(alpha-methyl-m-trifluoromethylphenethylamino)-, 4-chloro-3-sulfamoylbenzoate
2-({1-[3-(trifluoromethyl)phenyl]propan-2-yl}amino)ethyl 4-chloro-3-sulfamoylbenzoate
M-trifluoromethylphenyl-1-(beta-(sulfamyl-3'-chloro-4'-benzoyloxy)ethyl)amino-2-propane