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Methadone

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Identification
Molecular formula
C21H27NO
CAS number
76-99-3
IUPAC name
2-[(1-methyl-2,2-diphenyl-ethyl)amino]ethanol
State
State

At room temperature, methadone is typically found in solid form when in its pure salt form, such as methadone hydrochloride. This is the form typically used in medications, as the free base of methadone is an oil.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.00
Boiling point (Celsius)
394.80
Boiling point (Kelvin)
667.80
General information
Molecular weight
309.45g/mol
Molar mass
309.4500g/mol
Density
1.0189g/cm3
Appearence

Methadone, as a hydrochloride salt, usually appears as a white to off-white crystalline powder. It is soluble in water and alcohols, making it easy to formulate for pharmaceutical purposes. The compound itself might have a mild characteristic odor.

Comment on solubility

Solubility of 2-[(1-methyl-2,2-diphenyl-ethyl)amino]ethanol

The compound 2-[(1-methyl-2,2-diphenyl-ethyl)amino]ethanol, known for its complex structure, exhibits interesting solubility characteristics. Understanding the solubility of this compound is essential for its application in various chemical processes.

Factors Influencing Solubility

Several factors govern the solubility of this compound, including:

  • Polarity: The presence of the hydroxyl (–OH) group enhances solubility in polar solvents like water.
  • Hydrophobic character: The bulky diphenyl and methyl groups contribute to hydrophobicity, which can reduce solubility in polar environments.
  • Temperature: Increased temperature typically aids in solubility for many organic compounds, potentially allowing 2-[(1-methyl-2,2-diphenyl-ethyl)amino]ethanol to dissolve more readily in a broader range of solvents.

Solvent Compatibility

This compound is generally more soluble in organic solvents such as:

  • Dimethyl sulfoxide (DMSO)
  • Acetonitrile
  • Alcohols

However, it has limited solubility in pure aqueous solutions due to the aforementioned hydrophobic characteristics.

Summary

In conclusion, while 2-[(1-methyl-2,2-diphenyl-ethyl)amino]ethanol displays some solubility in polar solvents due to its hydroxyl functionality, it is predominantly more compatible with organic solvents owing to its hydrophobic elements. This unique balance between hydrophilicity and hydrophobicity renders its solubility profile both intriguing and useful in practical applications.

Interesting facts

Interesting Facts about 2-[(1-methyl-2,2-diphenyl-ethyl)amino]ethanol

This compound, known for its intriguing structure and properties, plays a unique role in both medicinal chemistry and organic synthesis. Here are some captivating aspects about it:

  • Dual functionality: The presence of both an amine and an alcohol functional group in its structure gives this compound the ability to participate in various chemical reactions, making it a valuable intermediate in the synthesis of other complex molecules.
  • Pharmacological significance: Compounds with similar amine and alcohol functionalities have been explored for their potential therapeutic effects, including but not limited to neuroprotective and anti-inflammatory properties.
  • Synthetic versatility: Scientists often utilize derivatives of this compound in the development of new pharmaceutical agents. Its synthetic routes provide a wealth of insights into the reactivity of related compounds.
  • Structure-activity relationship: The unique structural features, such as the diphenyl-ethyl moiety, allow researchers to study the effects of structural changes on biological activity, paving the way for drug design and optimization.
  • Impact on medicinal chemistry: Elements of its structure resemble that of various known drugs, illustrating how seemingly simple modifications can lead to compounds with vastly different biological outcomes.

In summary, 2-[(1-methyl-2,2-diphenyl-ethyl)amino]ethanol not only represents a fascinating molecule in the domain of organic chemistry but also opens doors to a better understanding of biological mechanisms and the creation of novel pharmaceuticals. As researchers continue to explore its potential applications, its role in future drug discovery remains an area of keen interest.

Synonyms
AKOS005893554