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Varenicline

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Identification
Molecular formula
C13H13N3
CAS number
249296-44-4
IUPAC name
2-(1-methyl-4-piperidyl)-5-(4-pyridyl)pyrazol-3-amine
State
State

At room temperature, varenicline is in a solid state.

Melting point (Celsius)
226.00
Melting point (Kelvin)
499.15
Boiling point (Celsius)
413.50
Boiling point (Kelvin)
686.60
General information
Molecular weight
211.27g/mol
Molar mass
211.2770g/mol
Density
1.3434g/cm3
Appearence

Varenicline typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-(1-methyl-4-piperidyl)-5-(4-pyridyl)pyrazol-3-amine

The solubility of 2-(1-methyl-4-piperidyl)-5-(4-pyridyl)pyrazol-3-amine can be influenced by various factors, including its chemical structure and interactions with solvents. This compound exhibits a unique solubility profile that can be examined through the following aspects:

  • Polarity: The presence of both piperidyl and pyridyl groups suggests a level of polarity, which may enhance solubility in polar solvents.
  • Hydrogen Bonding: The amine functional group can engage in hydrogen bonding, potentially increasing solubility in water and other polar solvents.
  • Solvent Choice: It is often more soluble in alcohols and dimethyl sulfoxide (DMSO), which can stabilize its structure due to compatible interactions.
  • pH Dependence: The solubility might vary with changes in pH, particularly for amines which can become protonated in acidic conditions, affecting their solubility characteristics.

Furthermore, it is essential to consider that the solubility can affect the compound's bioavailability and reactivity in various applications. As noted, “*the solubility of a compound is not just a measure of how much can dissolve, but also a key aspect of its functionality and potential uses*.” Understanding these elements can lead to better utilization of 2-(1-methyl-4-piperidyl)-5-(4-pyridyl)pyrazol-3-amine in practical scenarios.

Interesting facts

Interesting Facts about 2-(1-methyl-4-piperidyl)-5-(4-pyridyl)pyrazol-3-amine

This compound is a fascinating example of an organic molecule with potential implications in medicinal chemistry. Comprising a complex structure, it features both piperidine and pyridine moieties, which contribute to its unique characteristics. Here are some noteworthy points:

  • Biological Activity: Compounds similar to this one have demonstrated activity against various biological targets, making them candidates for drug development. The presence of the piperidine ring often leads to enhanced interaction with biological systems, particularly in neuropharmacology.
  • Structure-Activity Relationship: Understanding how the structure of this compound affects its activity is crucial for the design of new pharmaceuticals. The interplay between the piperidyl and pyridyl groups can influence selectivity and efficacy.
  • Relevance in Research: Research has shown that pyrazole derivatives possess anti-inflammatory, anticancer, and antimicrobial properties. This compound could potentially fall under similar classifications, aiding in the development of new therapeutic agents.
  • Synthetic pathways: The synthesis of this compound involves intricate multi-step reactions, emphasizing the importance of organic synthesis techniques in modern chemistry. Techniques such as cyclization and N-alkylation are commonly utilized in its preparation.

In conclusion, 2-(1-methyl-4-piperidyl)-5-(4-pyridyl)pyrazol-3-amine is not just a chemical entity but a potential key player in the ongoing quest for innovative medications. Scientists continue to explore its capabilities, hoping to unlock new therapeutic possibilities that could benefit a wide range of medical fields.

Synonyms
SCHEMBL997406
2-(1-methylpiperidin-4-yl)-5-pyridin-4-ylpyrazol-3-amine