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Phencyclidine

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Identification
Molecular formula
C17H23N
CAS number
77-10-1
IUPAC name
2-(1-methyl-4-piperidylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaene
State
State

At room temperature, phencyclidine usually exists as a solid in its base form. However, depending on the formulation and use, it can also be found dissolved in liquids or as a gaseous vapor when volatilized.

Melting point (Celsius)
46.50
Melting point (Kelvin)
319.65
Boiling point (Celsius)
136.50
Boiling point (Kelvin)
409.65
General information
Molecular weight
243.39g/mol
Molar mass
243.3900g/mol
Density
1.0065g/cm3
Appearence

Phencyclidine typically appears as a white crystalline powder. It can also be found as a colored powder or in liquid solution depending on its formulation and use. The compound is known for its relative stability under typical room temperature conditions.

Comment on solubility

Solubility of 2-(1-methyl-4-piperidylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaene

The solubility of 2-(1-methyl-4-piperidylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaene can be both intriguing and complex. Here are some key points regarding its solubility:

  • Polarity: The solubility of this compound is largely influenced by its polarity. Compounds with a nonpolar framework may exhibit low solubility in polar solvents, while polar solutes tend to be more soluble in polar solvents.
  • Solvent Compatibility: This compound may show varied solubility in a range of organic solvents. For instance, it might be soluble in chloroform, ethanol, or other organic solvents, but poorly soluble in water.
  • Temperature Effects: Generally, solubility can increase with temperature. For compounds like this, conducting solubility testing at different temperatures can yield valuable insights.
  • Hydrogen Bonding: If the compound can engage in hydrogen bonding, it might enhance its solubility in certain solvents, especially those that can form hydrogen bonds.

In summary, the solubility of 2-(1-methyl-4-piperidylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaene is determined by a diverse range of factors including polarity, solvent compatibility, temperature, and potential hydrogen bonding interactions. Understanding these aspects is crucial for determining the appropriate conditions for its dissolution.

Interesting facts

Interesting Facts about 2-(1-methyl-4-piperidylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaene

This fascinating compound belongs to a class known for its complex structure and potential applications in medicinal chemistry. Here are some interesting facts:

  • Structural Complexity: The compound features a unique tricyclic framework that can exhibit various stereochemistry. Such intricate structures are often a focus of study for understanding molecular interactions and reactivity.
  • Piperidine Influence: The piperidine moiety contributes significantly to the compound's overall properties, especially in the context of biological activities. Piperidine derivatives are frequently evaluated for their pharmacological potential.
  • Potential Biological Activity: Compounds like this one are often investigated for their effects on the nervous system, given their structural resemblance to neurotransmitter systems. The presence of nitrogen in the rings suggests possible interactions with receptors.
  • Organic Synthesis Challenges: The synthesis of such complex molecules presents interesting challenges in organic chemistry, pushing the boundaries of synthetic methodologies. Techniques like multi-step synthesis and stereoselective reactions are essential in creating these compounds.
  • Research Applications: Due to its unique properties, this compound could serve as a lead compound in drug discovery, allowing scientists to explore modifications that enhance efficacy and reduce side effects.

As we delve deeper into the chemistry of this compound, we recognize its potential to contribute to advances in pharmaceutical sciences and material sciences. Understanding such complex structures not only enriches our knowledge of chemical behaviors but also fuels innovation in various scientific fields.

Synonyms
AZATADINE
3964-81-6
Azatadina
Azatadinum
Azatadinum [INN-Latin]
Azatadina [INN-Spanish]
Azatadine [INN:BAN]
Azatadine (INN)
6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine
94Z39NID6C
CHEBI:2946
DTXSID6022636
AZATADINE [INN]
AZATADINE [MI]
AZATADINE [VANDF]
AZATADINE [WHO-DD]
Trinalin
DTXCID702636
11-(1-Methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Azatadinum (INN-Latin)
Azatadina (INN-Spanish)
5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-
2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaene
Idulamine
11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[3,4-b]pyridine
5H-BENZO(5,6)CYCLOHEPTA(1,2-B)PYRIDINE, 6,11-DIHYDRO-11-(1-METHYL-4-PIPERIDINYLIDENE)-
11-(1-Methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridine
11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo(1,2)cyclohepta(3,4-b)pyridine
2-(1-methylpiperidin-4-ylidene)-4-azatricyclo(9.4.0.0^(3,8))pentadeca-1(11),3,5,7,12,14-hexaene
R06AX09
Azatadine maleate; pseudoephedrine sulfate
AzatadineMaleate
CHEMBL946
11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Azatidine
2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaene
NCGC00182705-01
CAS-3964-81-6
UNII-94Z39NID6C
SCHEMBL3721
GTPL7119
BDBM22868
HY-B0170
Tox21_112982
AKOS030526143
Tox21_112982_1
CS-2047
DB00719
6,11-Dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
NCGC00182705-02
NS00007570
C07774
D07482
EN300-127917
AB01563291_01
AB01563291_02
L001081
Q599160
BRD-K77821588-050-01-7
BRD-K77821588-364-01-2
11-(1-Methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine #
11-(N-methyl-4-piperidylidene)-6,11-dihydro-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine
11-(N-methyl-4-piperidylidene)-6,11-dihydro-5H-benzo-[5,6]-cyclohepta[1,2-b]-pyridine
2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.0,3,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8]pentadeca-1(15),3(8),4,6,11,13-hexaene
2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaene