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Naproxen

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Identification
Molecular formula
C14H14O3
CAS number
22204-53-1
IUPAC name
2-(1-naphthyl)-3-(2-thienyl)propanoic acid
State
State

At room temperature, Naproxen exists in a solid state. Its crystalline structure is stable under normal environmental conditions, making it easy to handle and formulate.

Melting point (Celsius)
152.00
Melting point (Kelvin)
425.10
Boiling point (Celsius)
406.50
Boiling point (Kelvin)
679.70
General information
Molecular weight
230.26g/mol
Molar mass
230.2620g/mol
Density
1.2030g/cm3
Appearence

Naproxen appears as a white to off-white crystalline powder. It is known to be practically insoluble in water and freely soluble in ethanol. The crystalline nature of the compound gives it a distinct solid form with a consistent texture.

Comment on solubility

Solubility of 2-(1-naphthyl)-3-(2-thienyl)propanoic acid

The solubility of 2-(1-naphthyl)-3-(2-thienyl)propanoic acid can be characterized by several key aspects:

  • Polarity: This compound features both aromatic and aliphatic components, which generally yields moderate solubility in polar solvents.
  • Solvent Interaction: It is expected to show solubility in organic solvents such as ethyl acetate and dimethyl sulfoxide (DMSO), but might have limited solubility in water due to its non-polar naphthalene and thienyl groups.
  • Temperature Dependency: Like many organic acids, solubility may increase with temperature; hence, heating the solvent can enhance the dissolution process.
  • pH Effect: Being an acid, its ionization and, consequently, solubility may be influenced by changes in pH, potentially leading to greater solubility at lower pH levels.

As a result, the solubility profile of 2-(1-naphthyl)-3-(2-thienyl)propanoic acid suggests a complex interplay of structural features and environmental conditions, influencing its behavior in various solvents.

Interesting facts

Interesting Facts about 2-(1-naphthyl)-3-(2-thienyl)propanoic acid

2-(1-naphthyl)-3-(2-thienyl)propanoic acid, often abbreviated as NTPA, is a fascinating compound that finds its application in various fields of chemistry and pharmaceuticals. Here are some engaging insights about this unique compound:

  • Structural Diversity: The compound is characterized by a complex structure combining elements from both aromatic naphthalene and thiophene rings. This structural diversity leads to unique properties that can be beneficial in drug development.
  • Biological Relevance: Research indicates that derivatives of this compound may exhibit anti-inflammatory and analgesic properties, making it a candidate for further pharmaceutical exploration.
  • Synesthetic Applications: The presence of both aromatic and heteroaromatic groups enhances the compound's potential as a functional material, possibly paving the way for usage in organic electronics or sensors.
  • Study of Interactions: This compound serves as an interesting subject for studying interactions between different functional groups, especially in the context of *stereochemistry* and *reaction mechanisms*.
  • Focus of Research: As scientists look for innovative compounds, NTPA has caught the attention of researchers focusing on drug discovery and molecular design for new therapeutic agents.

Moreover, understanding the reactivity of 2-(1-naphthyl)-3-(2-thienyl)propanoic acid can open up pathways in both organic synthesis and medicinal chemistry. Its intricate structure inspires chemists to explore novel pathways and applications, making it a vital subject in contemporary chemical research.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This motto resonates well with the ongoing exploration of compounds like NTPA in the realm of science.

Synonyms
SCHEMBL3053079