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Naphazoline

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Identification
Molecular formula
C14H14N2
CAS number
835-31-4
IUPAC name
2-(1-naphthyl)-4,5-dihydro-1H-imidazole
State
State

At room temperature, naphazoline is generally found in the solid state as a crystalline powder.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
200.27g/mol
Molar mass
200.2690g/mol
Density
1.2104g/cm3
Appearence

Naphazoline typically appears as white to off-white crystalline powder.

Comment on solubility

Solubility of 2-(1-naphthyl)-4,5-dihydro-1H-imidazole

The solubility of 2-(1-naphthyl)-4,5-dihydro-1H-imidazole in various solvents can provide insight into its chemical behavior and potential applications. This compound, which contains a fused aromatic ring system, often displays limited solubility in polar solvents. Here are some key points regarding its solubility:

  • Polar Solvents: Generally, compounds with significant aromatic and nonpolar characteristics show low solubility in polar solvents such as water. This is due to their inability to form strong hydrogen bonds or favorable interactions with such solvents.
  • Nonpolar and Organic Solvents: It is more soluble in nonpolar or weakly polar organic solvents like chloroform or ether. This is attributed to the hydrophobic interactions present in these solvents.
  • Temperature Dependence: The solubility can also vary with temperature; typically, a rise in temperature increases solubility for many organic compounds.
  • pH Influence: The solubility might change with the pH of the environment, particularly if the compound can exist in ionized forms under different conditions.

In summary, the solubility of 2-(1-naphthyl)-4,5-dihydro-1H-imidazole is notably influenced by the solvent type, temperature, and pH conditions. Understanding these parameters is vital for optimizing its use in chemical reactions and applications.

Interesting facts

Exploring 2-(1-naphthyl)-4,5-dihydro-1H-imidazole

2-(1-naphthyl)-4,5-dihydro-1H-imidazole is a fascinating compound that combines elements of organic chemistry with unique structural characteristics. This compound is known for its involvement in various applications, especially in the field of medicinal chemistry.

Key Features

  • Structural Diversity: As a derivative of imidazole, it incorporates a naphthyl group, which contributes to its distinct properties. The naphthyl group adds an aromatic character, enhancing the compound's stability and reactivity.
  • Therapeutic Potential: Compounds like this one have been studied for their potential in developing pharmaceuticals, particularly as antimicrobial and antitumor agents. Research indicates that modifications to the imidazole ring can lead to significant biological activity.
  • Role in Organic Synthesis: The imidazole framework is a critical moiety in many organic reactions. This compound can serve as a building block for synthesizing other complex molecules, making it a valuable asset in drug discovery.

Interesting Applications

This compound has garnered attention in various scientific domains:

  • Used in studying the mechanisms of enzyme inhibition, which is crucial for understanding target sites for drug design.
  • Employed in the development of fluorescent probes due to the naphthalene's ability to absorb and emit light, making it suitable for biological imaging techniques.
  • Serves as a potential ligand in coordination chemistry, binding to metal ions and forming stable complexes with tailored properties.

As science continues to advance, compounds like 2-(1-naphthyl)-4,5-dihydro-1H-imidazole provide insights into new therapeutic agents and spark excitement among chemists and researchers alike. Being part of such a vibrant field highlights the compound's significance and opens up avenues for innovative research!

Synonyms
13623-57-9
2-(NAPHTHALEN-1-YL)-4,5-DIHYDRO-1H-IMIDAZOLE
2-IMIDAZOLINE, 2-(1-NAPHTHYL)-
CHEMBL418536
2-(1-Naphthyl)-4,5-dihydro-1H-imidazole
2-(1-Naphthyl)-2-imidazoline
BRN 0153198
2-Naphthalen-1-yl-4,5-dihydro-1H-imidazole
2-(Naphthyl-(1'))imidazolin [German]
2-(Naphthyl-(1'))imidazolin
1H-Imidazole, 4,5-dihydro-2-(1-naphthalenyl)-
5-23-08-00268 (Beilstein Handbook Reference)
SCHEMBL9575177
DTXSID30159737
BDBM50473173
HS-3475
E86954