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Naphthalene-1-acetic acid

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Identification
Molecular formula
C12H10O2
CAS number
86-87-3
IUPAC name
2-(1-naphthyl)acetic acid
State
State

At room temperature, Naphthalene-1-acetic acid is typically found in a solid state. Its crystalline form contributes to its solid structure, and it is generally stable.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.00
Boiling point (Celsius)
435.60
Boiling point (Kelvin)
708.80
General information
Molecular weight
186.21g/mol
Molar mass
186.2120g/mol
Density
1.2040g/cm3
Appearence

Naphthalene-1-acetic acid appears as an off-white to light yellow crystalline solid. It can form plate-like crystals and is relatively stable under standard conditions.

Comment on solubility

Solubility of 2-(1-naphthyl)acetic acid

2-(1-naphthyl)acetic acid, a compound with notable structural characteristics, has specific solubility traits worth discussing. When assessing its solubility, it is essential to consider the polar and nonpolar interactions involved. Here are some key points regarding its solubility:

  • Solvent Compatibility: 2-(1-naphthyl)acetic acid is generally soluble in organic solvents such as ethanol and acetone, as these solvents can interact favorably with the nonpolar aromatic naphthyl group.
  • Water Solubility: The solubility in water is quite limited. As a result, it is classified as relatively insoluble in water due to the hydrophobic nature of the naphthyl group.
  • pH Dependence: The solubility of this compound can increase in acidic or basic environments, as ionization can occur, enhancing its interaction with the solvent.
  • Temperature Effects: Like many organic compounds, solubility can increase with temperature, making hot solvents more effective for dissolution.

In summary, while 2-(1-naphthyl)acetic acid has a degree of solubility in organic solvents, its solubility in water is limited. Knowing these properties is vital in contexts such as extraction, formulation, or reaction scenarios.

Interesting facts

Interesting Facts about 2-(1-naphthyl)acetic Acid

2-(1-naphthyl)acetic acid is a fascinating compound with diverse applications and intriguing properties. It is a type of arylacetic acid that is structurally related to the larger class of non-steroidal anti-inflammatory drugs (NSAIDs). Here are some noteworthy points about this compound:

  • Biological Activity: This compound exhibits anti-inflammatory and analgesic properties, making it a subject of interest in medicinal chemistry.
  • Structure-Activity Relationship: The presence of the naphthalene moiety significantly influences its biological activity, demonstrating how small changes in structure can lead to different effects.
  • Pharmacological Applications: Researchers are exploring its potential as a lead in the development of new treatments for various inflammatory diseases.
  • Synthesis: There are multiple synthetic pathways to produce 2-(1-naphthyl)acetic acid, providing chemists with flexibility in the laboratory. Some methods utilize classical condensation reactions, while others employ more modern approaches like palladium-catalyzed coupling reactions.

In the words of a renowned chemist, "Understanding the subtle nuances of a compound's structure can unlock doors to innovative solutions for medical challenges." This sentiment encapsulates the spirit of exploration that surrounds 2-(1-naphthyl)acetic acid, paving the way for potential breakthroughs in the field of pharmaceuticals.

Overall, the study of 2-(1-naphthyl)acetic acid serves as a prime example of how fundamental chemistry can lead to significant advancements in healthcare and therapeutic interventions.

Synonyms
86-87-3
1-Naphthylacetic acid
1-NAPHTHALENEACETIC ACID
2-(Naphthalen-1-Yl)Acetic Acid
Naphthalene-1-acetic acid
NAPHTHALENEACETIC ACID
1-Naphthalene acetic acid
Phyomone
Planofix
Fruitone N
Fruitofix
Planofixe
Transplantone
Celmone
alpha-Naphthylacetic acid
Tre-hold
Stop-Drop
alpha-NAA
Alphaspra
Klingtite
Nafusaku
Primacol
Rhodofix
Tip-Off
Agronaa
Biokor
Etifix
Pomoxon
Stafast
Tekkam
Vardhak
Alman
Rasin
2-(1-Naphthyl)acetic acid
Liqui-stik
Pimacol-Sol
Appl-set
Rhizopon B
alpha-Naphthaleneacetic acid
naphthalen-1-ylacetic acid
Niagara-Stik
Nu-Tone
Naphthylacetic acid
Floramon
Hormofix
Plucker
Regenasol
Fruit Fix
NAA
1-Naphthtaleneacetic acid
1-Naphthylessigsaeure
Naphyl-1-essigsaeure
NAPHTHALEN-1-YL-ACETIC ACID
Caswell No. 589
.alpha.-NAA
STIK
Germon
1-NAA
2-naphthalen-1-ylacetic acid
.alpha.-Naphthaleneacetic acid
Stimolante 66f
HSDB 2038
alpha-Naphthyleneacetic acid
.alpha.-Naphthylacetic acid
Acide naphtylacetique
Acide naphthylacetique
Naphthaleneacetic acid (VAN)
NSC 15772
Naphthyl-1-essigsaeure
1-naphthyl acetic acid
Acide naphtylacetique [French]
Fruitone
Naphyl-1-essigsaeure [German]
Phymone
Kyselina 1-naftyloctova
2-(alpha-Naphthyl)ethanoic aid
Acide naphthylacetique [French]
alpha-Naphthylessigsaeure
EPA Pesticide Chemical Code 056002
2-(alpha-Naphthyl)ethanoic acid
Kyselina 1-naftyloctova [Czech]
Naphthyl-1-essigsaeure [German]
NAA 800
N 10
alpha-Naphthylessigsaeure [German]
AI3-16113
Acide naphtylacetique [ISO-French]
26445-01-2
EINECS 201-705-8
NAFTAL
CCRIS 8814
ANU
DTXSID8020915
CHEBI:32918
a-naphthaleneacetic acid
MFCD00004046
NSC-15772
RAIZON 05
33T7G7757C
(Naphthalen-1-yl)acetic acid
1-Naphthylacetic acid (JAN)
DTXCID60915
.alpha.-Naphthyleneacetic acid
CHEMBL428495
NAPHTHYLACETIC ACID [MART.]
1-NAPHTHYLACETIC ACID [JAN]
1-NAPHTHALENEACETIC ACID [MI]
ALPHA-NAPHTHYLACETIC ACID [HSDB]
NCGC00090987-02
NCGC00090987-03
1-NAPHTHALENEACETIC ACID [WHO-DD]
2-(.ALPHA.-NAPHTHYL)ETHANOIC ACID
NLA
Acide naphtylacetique (French)
(Naphthalen-1-yl)acetic Acid (1-Naphthylacetic Acid)
NAPHAZOLINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]
Acide naphtylacetique (ISO-French)
NAPHTHYLACETIC ACID (MART.)
CAS-86-87-3
NAPHTHYL-1-ESSIGSAEURE (GERMAN)
ALPHA-NAPHTHYLESSIGSAEURE (GERMAN)
alpha-naphthyl acetic acid
NAPHAZOLINE HYDROCHLORIDE IMPURITY B (EP IMPURITY)
Niagarastik
Pimacolsol
Applset
Liquistik
StopDrop
TreHold
TipOff
alphaNAA
NUTone
UNII-33T7G7757C
Naphyl1essigsaeure
1lrh
1Naphthylessigsaeure
Naphthyl1essigsaeure
naphthyl acetic acid
1Naphthylacetic Acid
NAA (auxin)
Naphthalene-1 acetic
naphthalenylacetic acid
Fruitone (Salt/Mix)
Kyselina 1naftyloctova
alphaNaphthylessigsaeure
Naphthalene1acetic acid
alphaNaphthylacetic acid
(1-naphthyl)acetic acid
1-naphtalene acetic acid
2-naphthalyl acetic acid
2(1Naphthyl)acetic acid
Naphtalene-1-acetic acid
1-naphthaleneethanoic acid
alphaNaphthyleneacetic acid
I+/--Naphthylacetic acid
(naphth-1-yl)acetic acid
.alpha.-Naphthylessigsaeure
2-(1-naphtyl)acetic acid
2(alphaNaphthyl)ethanoic aid
Oprea1_374703
SCHEMBL35925
WLN: L66J B1VQ
1-Naphthaleneacetic acid;NAA
MLS001055368
1-Naphthylacetic acid (NAA)
[3H]-NAA
1-Naphthaleneacetic acid, 97%
acetic acid, 2-(1-naphthyl)-
CHEBI:35629
1-Naphthaleneacetic acid (solid)
HMS1649K07
HMS3039O06
HMS3604I22
MSK24028
NSC15772
Tox21_111051
Tox21_400007
AC-640
BBL011795
BDBM50022186
s9362
STL163395
(1-Naphthyl)acetic acid, BSI, ISO
AKOS000104252
alpha-Naphthaleneacetic acid Free acid
Tox21_111051_1
1-Naphthalene-4-t-acetic acid (9CI)
CCG-266475
CS-6285
DB01750
FN14792
FS-2548
1-NAPHTHALENEACETIC ACID [INCI]
s12283
USEPA/OPP Pesticide Code: 056002
NCGC00090987-01
NCGC00090987-04
NCGC00090987-05
1-Naphthaleneacetic acid, technical grade
HY-18570
N 40
SMR000677931
1-Naphthaleneacetic acid (7CI,8CI,9CI)
DB-010855
N0005
NS00002971
EN300-18112
D01558
SBI-0653881.0001
AE-508/13205220
Q161660
Z57169437
F0020-1890
1-Naphthaleneacetic acid, PESTANAL(R), analytical standard
1-Naphthylacetic acid, 1 mg/mL, BioReagent, plant cell culture tested
1-Naphthaleneacetic acid, plant cell culture tested, BioReagent, >=95%, crystalline
201-705-8