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Naphazoline hydrochloride

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Identification
Molecular formula
C14H15N2·HCl
CAS number
550-99-2
IUPAC name
2-(1-naphthylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride
State
State

At room temperature, Naphazoline hydrochloride is in solid form. As a crystalline powder, it is stable under ambient conditions but should be stored in a dry environment to avoid absorption of moisture.

Melting point (Celsius)
254.00
Melting point (Kelvin)
527.15
Boiling point (Celsius)
323.00
Boiling point (Kelvin)
596.15
General information
Molecular weight
279.79g/mol
Molar mass
279.7860g/mol
Density
1.2000g/cm3
Appearence

Naphazoline hydrochloride appears as a white to off-white crystalline powder. It is typically odorless and can be dissolved in water and alcohol. The crystalline appearance may vary slightly based on the specific hydration state and purity of the sample.

Comment on solubility

Solubility of 2-(1-naphthylmethyl)-4,5-dihydro-1H-imidazole; hydrochloride

The solubility of 2-(1-naphthylmethyl)-4,5-dihydro-1H-imidazole; hydrochloride is an important characteristic that impacts its application in various chemical and pharmaceutical contexts. Understanding its solubility can help in predicting its behavior in different environments. Here are some key points to consider:

  • Water Solubility: This compound is expected to be soluble in water due to the presence of the hydrochloride form, which typically increases solubility through ionization.
  • Organic Solvents: It may also exhibit solubility in organic solvents, especially those that can stabilize the naphthylmethyl group.
  • pH Dependence: The solubility can be affected by the pH of the solution, as changes in acidity or basicity may alter the ionization state of the compound.
  • Temperature Effects: Like many compounds, solubility may increase with temperature, making it more soluble at elevated temperatures.

It is crucial to note that while solubility provides essential information for formulations, practical solubility in real-world scenarios should always be verified through empirical methods. Overall, the solubility characteristics of this compound can lead to significant implications for its usability in drug development and chemical synthesis.

Interesting facts

Exploring 2-(1-naphthylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride

This fascinating compound, commonly referred to as a derivative of imidazole, showcases the intricate connections between structure and function in chemical compounds. Here are some compelling aspects to consider:

  • Pharmacological Significance: Compounds like 2-(1-naphthylmethyl)-4,5-dihydro-1H-imidazole are often studied for their potential biological activities. The imidazole ring is a well-known motif in pharmacology, and such compounds may exhibit biological properties that can lead to the development of new therapeutic agents.
  • Structural Diversity: The presence of the naphthyl group adds intriguing structural complexity to this compound. Naphthalene derivatives are known for their aromatic characteristics, which can influence the physicochemical properties of the molecule, enhancing its interactions with biological targets.
  • Role of Hydrochloride Salt: The hydrochloride form can enhance the solubility and stability of the compound, making it particularly useful in pharmaceutical formulations. Such salts are often utilized to improve absorption rates and bioavailability in drug design.
  • Synthetic Routes: The synthesis of derivatives like this can illustrate various organic reactions, highlighting the importance of techniques such as nucleophilic substitutions, cyclizations, and functional group transformations in medicinal chemistry.

In summary, 2-(1-naphthylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride stands as an important example of how chemical intricacies translate into potential real-world applications, merging the realms of organic chemistry and pharmacology. As researchers delve into the world of such compounds, they unlock pathways toward innovative drug discoveries that can profoundly impact health and medicine.

As the great chemist Linus Pauling once said, “The best way to have a good idea is to have lots of ideas.” In this spirit, the exploration of compound derivatives continues to inspire advancements in the fascinating field of chemistry.

Synonyms
NAPHAZOLINE HYDROCHLORIDE
550-99-2
NAPHAZOLINE HCL
Opcon
Albalon Liquifilm
Rhinantin
Rhinoperd
Rinofug
Stricylon
Niazol
Privine hydrochloride
Clera hydrochloride
Naphazoline chloride
Coldan
Sanorin
Prizole hydrochloride
2-(1-Naphthylmethyl)-2-imidazoline hydrochloride
Naphazoliniumchlorid
Naphazolini chloridum
Naphthasolium chloride
2-(1-Naphthylmethyl)imidazoline hydrochloride
HSDB 2174
Naphthylmethylimidazolinhydrochlorid
EINECS 208-989-2
NSC 35711
NSC-35711
DTXSID7045788
UNII-MZ1131787D
2-(1-Naphthylmethyl)-2-imidazoline monohydrochloride
MZ1131787D
1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, monohydrochloride
2-Imidazoline, 2-(1-naphthylmethyl)-, monohydrochloride
DTXCID801011874
NSC35711
Naphazoline hydrochloride [USP:JAN]
OPCON-A COMPONENT NAPHAZOLINE HYDROCHLORIDE
VISINE-A COMPONENT NAPHAZOLINE HYDROCHLORIDE
NAPHCON-A COMPONENT NAPHAZOLINE HYDROCHLORIDE
VASOCON-A COMPONENT NAPHAZOLINE HYDROCHLORIDE
Strictylon
Sanorin-Spofa
Naphazoline hydrochloride (USP:JAN)
NAPHAZOLINE HYDROCHLORIDE (MART.)
NAPHAZOLINE HYDROCHLORIDE [MART.]
NAPHAZOLINE HYDROCHLORIDE (USP-RS)
NAPHAZOLINE HYDROCHLORIDE [USP-RS]
NAPHAZOLINE HYDROCHLORIDE (EP IMPURITY)
NAPHAZOLINE HYDROCHLORIDE (EP MONOGRAPH)
NAPHAZOLINE HYDROCHLORIDE [EP IMPURITY]
NAPHAZOLINE HYDROCHLORIDE [EP MONOGRAPH]
NAPHAZOLINE HYDROCHLORIDE (USP MONOGRAPH)
NAPHAZOLINE HYDROCHLORIDE [USP MONOGRAPH]
Nazal
Sato Clear
Pi Yuan Chin
NAFASOLINA
Hydrochloride, Naphazoline
Naphazoline Monohydrochloride
Monohydrochloride, Naphazoline
NAPHAZOLINE HYDROCHLORIDE COMPONENT OF OPCON-A
NAPHAZOLINE HYDROCHLORIDE COMPONENT OF VISINE-A
NAPHAZOLINE HYDROCHLORIDE COMPONENT OF NAPHCON-A
NAPHAZOLINE HYDROCHLORIDE COMPONENT OF VASOCON-A
2-(Naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole monohydrochloride
208-989-2
Albalon
Naphcon
Vasocon
Naphcon forte
NAFAZAIR
Naphazoline (hydrochloride)
MFCD00012554
2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole hydrochloride
MLS000028434
CHEBI:7470
Naphazoline hydrochloride (Naphcon)
SMR000058292
Vasoclear
2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride
Comfort Eye Drops
Degest-2
4,5-Dihydro-2-(1-naphthylmethyl)-1H-imidazole Hydrochloride
CHEMBL1706
Clear Eyes
Naphazoline hydrochloride [JAN]
CAS-550-99-2
Albacon
SR-01000000067
Prestwick_507
Albalon (TN)
Vasocon (TN)
component of Nasocon
Opera_ID_230
AC1LCWB1
SureCN1649580
SCHEMBL24153
MLS001148448
MLS002222217
NAPHAZOLINEHYDROCHLORIDE
SPECTRUM1500424
2-Imidazoline, monohydrochloride
HY-B0446R
MolPort-000-703-064
GLXC-06137
HMS1568I13
HMS1920P11
Pharmakon1600-01500424
EX-A4103
HY-B0446
Tox21_111255
CCG-40122
NSC757110
s2519
NAPHAZOLINE HYDROCHLORIDE [MI]
AKOS015908797
Naphazoline hydrochloride (JP18/USP)
Tox21_111255_1
FD11448
Naphazoline (hydrochloride) (Standard)
NC00523
NSC-757110
NAPHAZOLINE HYDROCHLORIDE [HSDB]
NAPHAZOLINE HYDROCHLORIDE [VANDF]
NCGC00016506-07
NCGC00094732-01
NCGC00094732-02
NCGC00094732-03
NCGC00094732-04
AS-16861
NAPHAZOLINE HYDROCHLORIDE [WHO-DD]
WLN: L66J B1- BT5M CN BUTJ &GH
LT00114215
LT00233108
N0542
NS00076392
SW196701-3
C07898
D00743
H12006
NAPHAZOLINE HYDROCHLORIDE [ORANGE BOOK]
SR-01000000067-3
Q27887678
1H-Imidazole,5-dihydro-2-(1-naphthalenylmethyl)-, monohydrochloride
hydron;2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole;chloride
2-(1-Naphthylmethyl)imidazoline hydrochloride;Naphazoline hydrochloride
Naphazoline hydrochloride, European Pharmacopoeia (EP) Reference Standard
Naphazoline hydrochloride, United States Pharmacopeia (USP) Reference Standard