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Nafamostat

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Identification
Molecular formula
C12H14N4
CAS number
81525-10-2
IUPAC name
2-(1-naphthylmethyl)guanidine
State
State

At room temperature, Nafamostat exists as a solid. It is stable under normal conditions and needs to be handled with care to prevent decomposition.

Melting point (Celsius)
154.50
Melting point (Kelvin)
427.65
Boiling point (Celsius)
487.60
Boiling point (Kelvin)
760.75
General information
Molecular weight
202.27g/mol
Molar mass
202.2610g/mol
Density
1.3000g/cm3
Appearence

Nafamostat is typically seen as a white to off-white crystalline powder. It is odorless and can slightly vary in its shade due to different conditions during its preparation.

Comment on solubility

Solubility of 2-(1-naphthylmethyl)guanidine

2-(1-naphthylmethyl)guanidine is known for its unique solubility characteristics, largely influenced by its molecular structure and the presence of functional groups. Here are some key points regarding its solubility:

  • Solvent Preference: This compound exhibits a varied solubility profile in different solvents. It is generally soluble in polar organic solvents such as methanol and ethanol, while showing lower solubility in non-polar solvents.
  • Influence of Temperature: The solubility of 2-(1-naphthylmethyl)guanidine can significantly increase with rising temperatures. This can be attributed to enhanced molecular interactions and decreased solute-solute interactions at higher thermal energies.
  • Hydrogen Bonding: The guanidine functionality allows for the formation of hydrogen bonds, which can enhance solubility in polar solvents. This means that the presence of water can play a role in how effectively the compound dissolves.
  • Concentration Effects: At higher concentrations, solubility may be limited by precipitation, indicating that there is a solubility limit that must be observed when considering formulations or solutions.

In summary, while 2-(1-naphthylmethyl)guanidine shows promising solubility in polar solvents, its overall behavior is complex and highly dependent on external conditions such as temperature, solvent nature, and concentration. Understanding these properties is crucial for its application in various chemical contexts.

Interesting facts

Interesting Facts About 2-(1-Naphthylmethyl)guanidine

2-(1-Naphthylmethyl)guanidine is an intriguing chemical compound that has gained attention in various fields of research. Here are some fascinating insights into this compound:

  • Versatile Applications: This compound is recognized for its potential use in medicinal chemistry. It has been studied for its biological activities and possible therapeutic applications, particularly in the realm of antiproliferative and antimicrobial effects.
  • Chemical Structure: The presence of a naphthyl group in its structure enhances its lipophilicity, which is vital for permeability through cell membranes. This feature makes it a subject of interest for drug development.
  • Research Background: Various studies have explored its role as a guanidine derivative. Guanidines are known for their ability to modulate biological systems, making them essential in pharmacology.
  • Biological Mechanisms: It is hypothesized that the mechanisms of action involve multiple pathways, including potential interactions with receptors and influencing cellular signaling.
  • Future Prospects: Ongoing research may unveil new therapeutic avenues. Its unique properties could pave the way for innovative treatments in areas like cancer therapy or infectious diseases.

In summary, 2-(1-Naphthylmethyl)guanidine showcases a blend of exciting chemical properties and promising applications. As research expands, this compound may contribute to significant advancements in medicinal and pharmaceutical chemistry.

Synonyms
(1-NAPHTHYLMETHYL)GUANIDINE
5696-79-7
1-(Naphthalen-1-ylmethyl)guanidine
2-(naphthalen-1-ylmethyl)guanidine
N-[(naphthalen-1-yl)methyl]guanidine
1-(1-Naphthylmethyl)guanidine
833DTD9XCF
CHEMBL319643
SCHEMBL4100261
N-(1-Naphthalenylmethyl)guanidine
AKOS011653997
Guanidine, N-(1-naphthalenylmethyl)-
SY340584
N-(NAPHTHALEN-1-YLMETHYL)GUANIDINE
EN300-243930