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2-(1-phenylethoxy)guanidine

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Identification
Molecular formula
C9H14N2O
CAS number
7167-91-9
IUPAC name
2-(1-phenylethoxy)guanidine
State
State

Under standard conditions, 2-(1-phenylethoxy)guanidine is typically found as a liquid. However, it can also be in a solid state at temperatures below its melting point.

Melting point (Celsius)
45.00
Melting point (Kelvin)
318.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
177.23g/mol
Molar mass
177.2260g/mol
Density
1.0800g/cm3
Appearence

2-(1-phenylethoxy)guanidine typically appears as a colorless to pale yellow liquid under normal conditions. It can also exist in a crystalline solid form depending on purity and temperature.

Comment on solubility

Solubility of 2-(1-phenylethoxy)guanidine

2-(1-phenylethoxy)guanidine, a compound characterized by its complex structure, exhibits a moderate solubility profile in various solvents. Its solubility characteristics can be summarized as follows:

  • Water solubility: This compound shows limited solubility in water, typically due to the presence of the organic phenylethoxy group, which can hinder interaction with polar solvents.
  • Organic solvents: 2-(1-phenylethoxy)guanidine is often more soluble in non-polar or slightly polar organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO).
  • Temperature effects: As with many organic compounds, solubility may increase with temperature, making heating a useful strategy in practical applications.

When examining the solubility of this compound, it is essential to consider the following factors:

  • Hydrophobic vs. hydrophilic character: The balance between the hydrophobic phenyl group and the hydrophilic guanidine group plays a crucial role in determining solubility.
  • pH influence: The solubility may vary with changes in pH, particularly due to protonation states at different pH levels.

In summary, 2-(1-phenylethoxy)guanidine demonstrates a unique solubility behavior that depends on the solvent environment and external conditions. Understanding these parameters is crucial for optimal usage in various chemical applications.

Interesting facts

Interesting Facts about 2-(1-phenylethoxy)guanidine

2-(1-phenylethoxy)guanidine is a fascinating compound in the realm of organic chemistry, mainly known for its versatility and application in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Medicinal Applications: This compound is being researched for its potential therapeutic effects, particularly in the treatment of various diseases due to its guanidine structure, which is known for its bioactivity.
  • Structure-Activity Relationship: The presence of the phenylethoxy group enhances solubility and bioavailability, making it a subject of interest for drug formulation studies.
  • Guanidine Derivatives: Guanidine derivatives have long been recognized for their importance in the synthesis of pharmacologically active compounds. 2-(1-phenylethoxy)guanidine can serve as a precursor for creating more complex molecular structures.
  • Physiological Role: Compounds like this one are often investigated for their interactions with various biological receptors and enzymes, providing insights into their potential role in biological processes.
  • Research Interest: As a compound that bridges organic synthesis with biochemical research, it’s often highlighted in publications focusing on novel therapeutic agents.

In summary, 2-(1-phenylethoxy)guanidine exemplifies the innovative nature of organic chemistry, where simple modifications to existing structures can lead to significant advances in drug discovery and development. The ongoing research that delves into its capabilities not only expands our understanding of medicinal chemistry but also opens new pathways for therapeutic applications.