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2-(1-Piperidyl)acetonitrile

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Identification
Molecular formula
C7H12N2
CAS number
15879-15-5
IUPAC name
2-(1-piperidyl)acetonitrile
State
State

The compound is in a liquid state at room temperature.

Melting point (Celsius)
-12.00
Melting point (Kelvin)
261.15
Boiling point (Celsius)
239.00
Boiling point (Kelvin)
512.15
General information
Molecular weight
122.18g/mol
Molar mass
122.1830g/mol
Density
1.0105g/cm3
Appearence

2-(1-Piperidyl)acetonitrile is typically a colorless to pale yellow liquid, depending on its purity. It is known for its characteristic odor, often associated with aliphatic nitriles.

Comment on solubility

Solubility of 2-(1-piperidyl)acetonitrile

The solubility of 2-(1-piperidyl)acetonitrile can be influenced by several factors, particularly due to its unique structural features. As a nitrile compound, it typically exhibits the following solubility characteristics:

  • Polarity: The presence of the acetonitrile functional group contributes to the overall polarity of the molecule, making it more soluble in polar solvents.
  • Solvent Compatibility: 2-(1-piperidyl)acetonitrile is expected to have good solubility in water, ethanol, and other polar aprotic solvents due to its piperidine group and the acetonitrile moiety.
  • Hydrogen Bonding: The nitrogen atoms in both the piperidine and the nitrile contribute to hydrogen bonding capabilities, enhancing solubility in aqueous solutions.

Generally, when assessing solubility, it's important to consider:

  1. Temperature: Solubility can increase with rising temperatures.
  2. pH Level: The protonation state of the piperidine nitrogen may alter solubility in different pH environments.
  3. Impurities: The presence of other solutes can affect solubility behavior.

In summary, 2-(1-piperidyl)acetonitrile displays robust solubility in polar solvents, primarily due to its polar character and ability to engage in hydrogen bonding. This makes it a compound of interest in various chemical applications where solubility plays a crucial role.

Interesting facts

Interesting Facts about 2-(1-piperidyl)acetonitrile

2-(1-piperidyl)acetonitrile is a fascinating compound known for its significance in pharmaceutical research and organic chemistry. This compound is notable for its connection to various medicinal applications, particularly in the development of new drugs. Here are some intriguing facts:

  • Structural Features: The presence of the piperidine ring confers unique properties to the compound, enhancing its ability to interact with biological targets.
  • Pharmaceutical Relevance: Compounds like 2-(1-piperidyl)acetonitrile are often explored for their potential as antidepressants, antipsychotics, and analgesics, contributing to advancements in mental health therapeutics.
  • Synthetic Versatility: This compound serves as a versatile building block in organic synthesis, enabling the creation of more complex molecules, which can lead to significant discoveries in material sciences and biochemistry.
  • Research Applications: Scientists utilize 2-(1-piperidyl)acetonitrile in various research contexts, investigating its properties and effects which could lead to breakthroughs in understanding neurological disorders.
  • Safety Precautions: As with many nitriles, handling 2-(1-piperidyl)acetonitrile requires caution due to potential toxicity. Proper safety protocols should be adhered to in laboratory environments.

The potential of 2-(1-piperidyl)acetonitrile continues to draw the attention of chemists and pharmacologists alike, emphasizing the importance of interdisciplinary approaches in the quest for innovative therapeutic solutions. In the words of a noted chemist, "The beauty of organic chemistry lies in its complexity and the endless possibilities it offers for discovery."

Synonyms
3010-03-5
Piperidinoacetonitrile
1-Piperidineacetonitrile
Piperidoacetonitrile
ACETONITRILE, PIPERIDINO-
N-Piperidinoacetonitrile
Piperidine-1-acetonitrile
N-(Cyanomethyl)piperidine
NSC 26716
W8I8FIB013
EINECS 221-131-1
NSC 47261
NSC 62871
NSC-26716
NSC-47261
NSC-62871
BRN 0108905
AI3-15234
DTXSID30184185
5-20-03-00029 (Beilstein Handbook Reference)
DTXCID40106676
N-Cyanomethylpiperidine
1-Cyanomethylpiperidine
piperidin-1-ylacetonitrile
2-(piperidin-1-yl)acetonitrile
2-piperidin-1-ylacetonitrile
(Piperidin-1-yl)acetonitrile
1-Piperidinoacetonitrile
MFCD00023733
WLN: T6MTJ X1CN
2-piperidinoacetonitrile
1-(Cyanomethyl)piperidine
Piperidinoacetonitril
1-Piperidinylacetonitrile
piperidine, 1-cyanomethyl-
1-Piperidinylacetonitrile #
UNII-W8I8FIB013
2-(1-piperidyl)acetonitrile
SCHEMBL64903
CHEMBL1193397
CLVBVRODHJFTGF-UHFFFAOYSA-
ALBB-004596
CS-D1261
NSC26716
NSC47261
NSC62871
STK503243
AKOS000190043
PS-4313
CS-10229
NS00028851
EN300-64889
D89390
Z169223032
InChI=1/C7H12N2/c8-4-7-9-5-2-1-3-6-9/h1-3,5-7H2