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Etomidate

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Identification
Molecular formula
C14H16ClN1O2
CAS number
33125-97-2
IUPAC name
2-(1-piperidyl)ethyl N-(2-chlorophenyl)carbamate
State
State

At room temperature, Etomidate is a solid. It is typically stored in a powdered, crystalline form for clinical use but is often dissolved in a lipid emulsion or other suitable solvent for intravenous administration.

Melting point (Celsius)
74.00
Melting point (Kelvin)
347.15
Boiling point (Celsius)
502.80
Boiling point (Kelvin)
775.95
General information
Molecular weight
244.74g/mol
Molar mass
244.7390g/mol
Density
1.2033g/cm3
Appearence

Etomidate typically appears as a white crystalline solid. It is known for its use as a short-acting intravenous anaesthetic agent used for the induction of general anaesthesia and sedation for short procedures such as reduction of dislocated joints, tracheal intubation, cardioversion, and electroconvulsive therapy. As a solid, it lacks any distinct odour.

Comment on solubility

Solubility Overview of 2-(1-piperidyl)ethyl N-(2-chlorophenyl)carbamate

The solubility of 2-(1-piperidyl)ethyl N-(2-chlorophenyl)carbamate can be influenced by various factors such as temperature, pH, and the presence of solvents. Here are some key points to consider regarding its solubility:

  • Solvent Compatibility: This compound may exhibit different solubility in polar and non-polar solvents.
    For example:
    - Highly polar solvents like water might show limited solubility.
    - Organic solvents such as ethanol or acetone could enhance solubility.
  • Temperature Dependence: Generally, increasing the temperature tends to increase solubility for solid compounds. Thus, heating the solvent may be beneficial.
  • pH Influence: The solubility of this carbamate may also vary significantly with pH due to its potential ionization in acidic or basic conditions.
  • Complexation: This compound could form complexes with certain cations or anions, further altering its solubility profile.

Overall, understanding the solubility of 2-(1-piperidyl)ethyl N-(2-chlorophenyl)carbamate is crucial for applications in pharmaceuticals and chemical research. Conducting thorough solubility tests across various conditions will provide valuable insights into its behavior in different chemical environments.

Interesting facts

Interesting Facts about 2-(1-Piperidyl)ethyl N-(2-chlorophenyl)carbamate

2-(1-Piperidyl)ethyl N-(2-chlorophenyl)carbamate is a fascinating compound notable for its various applications and unique properties. Here are some intriguing points to consider:

  • Purposeful Design: This compound is a derivative of carbamate, which plays a significant role in medicinal chemistry. Its design often centers around enhancing pharmacological efficacy while minimizing side effects.
  • Pharmacological Relevance: Compounds like this one are explored in the context of neuropharmacology. They may have implications in treating neurological disorders due to their interaction with specific receptors in the brain.
  • Structural Variety: The presence of both a piperidine ring and a chlorophenyl group creates a diversified structure, allowing researchers to modify it easily for tailored therapeutic effects.
  • Chirality and Isomerism: The stereochemistry of this compound can significantly affect its biological activity, presenting an intriguing area for study in designing more potent derivatives.
  • Research Potential: Ongoing research often focuses on the synthesis of analogs that may demonstrate improved activity or selectivity for certain biological targets, making this compound a potential lead in drug discovery.
  • Environmental Impact: Like many carbamate derivatives, understanding the breakdown and environmental interactions of this chemical is crucial, especially with respect to its persistence and bioaccumulation.

In conclusion, the compound 2-(1-piperidyl)ethyl N-(2-chlorophenyl)carbamate exemplifies the intricate balance of structure and function in medicinal chemistry. As research continues, the potential applications and understanding of such compounds are likely to expand, highlighting their importance in both scientific exploration and practical applications.

Synonyms
CHEMBL51218
BDBM50058188
(2-Chloro-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester