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2-(1-Piperidylmethyl)tetralin-1-one

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Identification
Molecular formula
C16H21NO
CAS number
89997-13-5
IUPAC name
2-(1-piperidylmethyl)tetralin-1-one
State
State

Solid at room temperature.

Melting point (Celsius)
131.50
Melting point (Kelvin)
404.60
Boiling point (Celsius)
325.50
Boiling point (Kelvin)
598.60
General information
Molecular weight
241.35g/mol
Molar mass
241.3490g/mol
Density
1.1435g/cm3
Appearence

2-(1-Piperidylmethyl)tetralin-1-one appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-(1-piperidylmethyl)tetralin-1-one

2-(1-piperidylmethyl)tetralin-1-one exhibits intriguing solubility characteristics that may vary depending on several factors such as temperature and the solvent used. Understanding its solubility is crucial, especially in fields like pharmacology and material science.

Solubility Characteristics

  • Solvent Polarity: The solubility of 2-(1-piperidylmethyl)tetralin-1-one tends to be greater in polar solvents compared to non-polar solvents due to its functional groups.
  • Temperature Effect: Like many organic compounds, its solubility can increase with rising temperatures, making it easier to dissolve in hot solvents.
  • pH Sensitivity: This compound may also exhibit variable solubility in aqueous solutions depending on pH, particularly due to its potential ionizable groups.
  • Hydrogen Bonding: The presence of piperidine can facilitate hydrogen bonding, enhancing solubility in certain polar solvents.

As with many compounds, the specific interaction of 2-(1-piperidylmethyl)tetralin-1-one with various solvent environments can lead to diverse solubility behaviors. Understanding these factors can provide insights into its bioavailability, reaction rates in solution, and potential applications in drug formulation.

Interesting facts

Interesting Facts about 2-(1-piperidylmethyl)tetralin-1-one

2-(1-piperidylmethyl)tetralin-1-one is a fascinating compound with several intriguing characteristics. This compound is a member of the class of organic chemicals known as *amines*, specifically a piperidine derivative, which has a cyclic structure that contributes to its unique properties and behavior.

Key Features and Applications

  • Pharmaceutical Relevance: Compounds like 2-(1-piperidylmethyl)tetralin-1-one are often studied for their potential pharmacological effects. They may serve as precursors or intermediates in the synthesis of pharmaceuticals, including antidepressants and analgesics.
  • Structural Versatility: The tetralin structure lends itself to a variety of modifications, allowing for the development of novel compounds that can target specific biological pathways.
  • Cognitive Function: Research has suggested that piperidine derivatives may influence neurotransmission and could thus have implications for improving cognitive function or treating neurological disorders.

Significance in Research

This compound provides an excellent platform for researchers interested in drug design and synthesis. Its unique structure allows for diverse chemical reactions, making it a valuable compound for studying structure-activity relationships in medicinal chemistry.

Furthermore, due to the cyclic nature of its components, understanding the sterics and electronics of 2-(1-piperidylmethyl)tetralin-1-one can offer insight into improving the efficacy and selectivity of drug candidates. As noted in recent studies, "exploring the subtle variations in such compounds can lead to significant advancements in therapeutic interventions."

In conclusion, 2-(1-piperidylmethyl)tetralin-1-one is more than just a chemical entity; it represents a potential gateway to innovative solutions in pharmacology and medicinal chemistry.

Synonyms
2-Piperidinomethyl-1-tetralone
4706-74-5
BRN 0199049
1-Piperidinomethyl-tetralon-2 [German]
1-Piperidinomethyl-tetralon-2
2-(Piperidino)methyl-3,4-dihydro-1(2H)-naphthalenone
1(2H)-NAPHTHALENONE, 3,4-DIHYDRO-2-(PIPERIDINO)METHYL-
CHEMBL3303730
DTXSID70963734
2-(1-piperidylmethyl)tetralin-1-one
2-[(Piperidin-1-yl)methyl]-3,4-dihydronaphthalen-1(2H)-one