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Cortisone acetate

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Identification
Molecular formula
C23H30O6
CAS number
50-04-4
IUPAC name
[2-(11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] acetate
State
State

At room temperature, cortisone acetate is typically in a solid state. It is stable under general conditions but should be stored away from light and moisture.

Melting point (Celsius)
222.00
Melting point (Kelvin)
495.15
Boiling point (Celsius)
443.70
Boiling point (Kelvin)
716.85
General information
Molecular weight
402.49g/mol
Molar mass
402.4900g/mol
Density
1.3200g/cm3
Appearence

Cortisone acetate appears as a white or nearly white crystalline powder. It is generally odorless and its appearance can be described as fine powdery in nature.

Comment on solubility

Solubility of 2-(11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl acetate

The solubility of the compound 2-(11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl acetate can be influenced by several factors, primarily related to its molecular structure and functional groups.

Factors Affecting Solubility:

  • Polarity: The presence of polar functional groups, like the acetate and hydroxyl moieties, generally improves solubility in polar solvents.
  • Molecular Weight: The relatively high molecular weight of this compound may reduce its solubility in certain organic solvents.
  • Hydrogen Bonding: Hydrogen bonding potential due to hydroxyl groups can enhance solubility in water and other polar solvents.
  • Solvent Interaction: Solubility is often greater in organic solvents than in water if the compound contains significant hydrophobic portions.

As with many organic compounds, it is likely that solubility will vary significantly across different solvents. To summarize:

Predicted Solubility Characteristics:

  • More soluble in polar solvents due to functional groups.
  • Potentially less soluble in non-polar solvents due to overall molecular size and structure.
  • In water, solubility may be limited, but can be improved with the addition of suitable co-solvents.

Ultimately, experimental solubility studies are essential for accurate assessment. Laboratory conditions and the choice of solvent will provide the best insight into the solubility behavior of this compound.

Interesting facts

Interesting Facts about 2-(11-Hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl Acetate

This compound is quite fascinating due to its complex structure and potential biological significance. It belongs to a class of compounds known as steroids, which are characterized by a specific arrangement of four interconnected carbon rings. Here are several key aspects about this chemical:

  • Bioactive Properties: Many compounds within the steroid family exhibit important biological activities, including hormone regulation, anti-inflammatory effects, and modulation of various metabolic processes.
  • Synthesis: The synthesis of this compound can be incredibly challenging due to the intricate configuration of functional groups and the stereochemistry involved. Techniques such as asymmetric synthesis and molecular rearrangement can be particularly vital in producing this specific acetate.
  • Potential Uses: Compounds similar to this acetate are often investigated for their therapeutic potential. Possible applications include:
    • Hormonal therapies
    • Anti-cancer treatments
    • Cardiovascular health improvement
  • Structural Diversity: The complexity of its structure, with multiple functional groups, opens up discussions regarding its reactivity and interactions with biological systems. The presence of the acetate group indicates potential for esterification reactions.
  • Natural Occurrence: Surprisingly, many steroids, including derivatives like this one, are naturally occurring in plants and animals, playing crucial roles in both human and ecological health.

In summary, the exploration of compounds like 2-(11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl acetate not only enhances our understanding of synthetic organic chemistry but also bridges the gap between chemistry and biology, showcasing the profound impact that molecular structure has on function.

Synonyms
NCIOpen2_009001
CHEMBL109722
SCHEMBL22039181
WKQCPUMQBMFPLC-UHFFFAOYSA-N
DB-041363
2-{10-hydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,8H,9H,9bH,10H,11H-cyclopenta[a]phenanthren-1-yl}-2-oxoethyl acetate