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Estrone acetate

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Identification
Molecular formula
C20H24O4
CAS number
901-36-6
IUPAC name
[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] acetate
State
State

At room temperature, estrone acetate is typically found in a solid state as it is a crystalline powder.

Melting point (Celsius)
184.00
Melting point (Kelvin)
457.15
Boiling point (Celsius)
595.20
Boiling point (Kelvin)
868.35
General information
Molecular weight
330.45g/mol
Molar mass
330.4480g/mol
Density
1.1700g/cm3
Appearence

Estrone acetate typically appears as a white to off-white crystalline powder. It may have a slightly characteristic odor, but is predominantly odorless.

Comment on solubility

Solubility of [2-(11,17-Dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] acetate (C20H24O4)

The solubility profile of this compound is intricate due to its complex structural features. Understanding its solubility is vital for various applications, particularly in pharmaceutical formulations. Here are some essential points regarding its solubility:

  • Polarity: The presence of multiple hydroxyl (-OH) groups suggests potential for hydrogen bonding with solvents. This generally indicates a higher solubility in polar solvents like water.
  • Hydrophobic Effects: The significant hydrophobic parts of the molecule, detailed by the cyclopenta[a]phenanthrene structure, may lower its solubility in polar solvents despite the hydroxyl groups.
  • Solvent Compatibility: It is likely to exhibit better solubility in organic solvents (such as ethanol, methanol, and acetone) due to the ester and ketone functionalities enhancing interaction with non-polar and semi-polar solvents.
  • Temperature Influence: As with many organic compounds, an increase in temperature is likely to enhance solubility, promoting kinetic energy and disrupting molecular interactions.

In conclusion, while the compound has the potential for solubility in various solvents, the balance between its polar and non-polar characteristics creates a unique solubility profile that warrants careful consideration in experimental and application settings.

Interesting facts

Interesting Facts about 2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl acetate

This compound, known for its complex structure, holds significant interest in the field of organic chemistry. Here are some fascinating insights about it:

  • Structure Diversity: The compound features an elaborate polycyclic structure, which is characteristic of many steroid-like molecules. This complexity can lead to unique biological activities.
  • Functional Groups: With multiple hydroxyl groups (-OH) and a ketone group (=O) in its structure, it is likely to exhibit interesting reactivity. This versatility can be harnessed in various synthetic applications.
  • Biological Implications: Compounds with similar steroidal frameworks are often biologically active and can influence hormonal pathways. Research into such derivatives can yield potential therapeutic agents.
  • Potential for Derivative Synthesis: The presence of the acetate group hints at possible esterification reactions, allowing chemists to manipulate its reactivity and form derivatives with tailored properties.

As a chemistry student or scientist, one might find it exhilarating to explore the potential transformations of this compound and its analogs. Understanding its synthesis and applications could lead to discoveries with significant implications in pharmacology and medicinal chemistry.

In summary, the exploration of 2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl acetate serves as a reminder of the intricate relationships between molecular structure and function in the realm of chemical science.

Synonyms
Pred Forte
PREDNISOLONE-21-ACETATE
11,17-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate
MLS000861600
CHEMBL1519597
HMS2802G03
2-{1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl}-2-oxoethyl acetate
BBL036317
CCG-43930
STL450998
AKOS025149896
[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl] acetate
SMR000460384
VS-13418
SR-01000633805-1
BRD-A83567094-001-03-6